Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Brian S Hilbush"'
Autor:
Brian S. Hilbush
Learn how AI and data science are upending the worlds of biology and medicine In Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future delivers an illuminating and fresh perspective on the convergence of
Autor:
Joseph G. Gleeson, Francisco M. De La Vega, Rebecca A. Betensky, Ayman W. El-Hattab, Brian S Hilbush, Michael M. Segal, Gerard Tromp, Mostafa Abdellateef, Marc S. Williams
Publikováno v:
Journal of Child Neurology
We describe an “integrated genome-phenome analysis” that combines both genomic sequence data and clinical information for genomic diagnosis. It is novel in that it uses robust diagnostic decision support and combines the clinical differential dia
Publikováno v:
Journal of Neuroscience Research. 89:808-814
Three loci that modify β-amyloid (Aβ) accumulation and deposition in the brains of a mouse model of Alzheimer's disease have been previously described. One encompasses the Psen2 gene encoding presenilin 2, a component of the γ-secretase activity r
Autor:
J. Gregor Sutcliffe, P. Austin Nelson, Brian S. Hilbush, Karl W. Hasel, Patria E. Danielson, Elizabeth A. Thomas, Thomas M. Pribyl
Publikováno v:
Journal of Neurochemistry. 76:789-796
In contrast to typical neuroleptic drugs, which have high affinities for dopamine D2 receptors, clozapine binds to multiple neurotransmitter receptors. The mechanisms responsible for its superior clinical efficacy over typical neuroleptics remain unk
Autor:
Brian S Hilbush, Justin M. Zook, Alan Jackson, John G. Cleary, Richard Littin, Sean A. Irvine, David Ware, S. Inglis, Len Trigg, Ross Braithwaite, Francisco M. De La Vega, Mehul Kamlesh Rathod, Kurt Gaastra
To evaluate and compare the performance of variant calling methods and their confidence scores, comparisons between a test call set and a ?gold standard? need to be carried out. Unfortunately, these comparisons are not straightforward with the curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7020e90502268f9b7334f18dee6d57a
Publikováno v:
NeuroRX. 2:627-637
Summary: The future of neurodegenerative therapeutics development depends upon effective disease modification strategies centered on carefully investigated targets. Pharmaceutical research endeavors that probe for a much deeper understanding of disea
Autor:
Andrew Middlecamp, Dale A. Pelligrino, Sergey Kalinin, Susan O. McGuire, Douglas L. Feinstein, Brian S. Hilbush, Vitaliy Gavrilyuk, Guy L. Weinberg
Publikováno v:
Journal of Neurochemistry. 92:1140-1149
Brain inflammation is regulated by endogenous substances, including neurotransmitters such as noradrenaline (NA), which can increase anti-inflammatory genes. To identify NA-regulated, anti-inflammatory genes, we used TOGA (total gene expression analy
Autor:
J. Gregor Sutcliffe, Brian S. Hilbush, Luca G. Guidotti, Francis V. Chisari, Stefan Wieland, Raquel Vega, Claire F. Evans, Rolf Müller, Peter G. Schultz
Publikováno v:
Journal of Virology. 77:1227-1236
We have previously shown that alpha/beta interferon (IFN-α/β) and IFN-γ inhibit hepatitis B virus (HBV) replication noncytopathically in the livers of HBV transgenic mice and in hepatocyte cell lines derived from these mice. The present study was
Autor:
Monica J. Carson, Karl W. Hasel, Brian S. Hilbush, Lauren N. Sautkulis, J. Gregor Sutcliffe, Christoph D. Schmid, Patria E. Danielson, Judith Cooper
Publikováno v:
Journal of Neurochemistry. 83:1309-1320
Microglial activation is an early and common feature of almost all neuropathologies, including multiple sclerosis, Alzheimer's disease and mechanical injury. To better understand the relative contributions microglia make toward neurodegeneration and
Autor:
Steven P. Mah, David Lo, David J. Brayden, Daragh Byrne, Daniel J. O'mahony, Brian S. Hilbush, Lisa Higgins
Publikováno v:
Advanced Drug Delivery Reviews. 54:1213-1223
Drug delivery technologies are commonly directed towards formulations to control the delivery of therapeutic compounds. However, many processes in the human body have evolved to regulate the transport of various molecules, cells, or particles across