Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Brian S, Safina"'
Autor:
Girish Bankar, Samuel J. Goodchild, Sarah Howard, Karen Nelkenbrecher, Matthew Waldbrook, Michelle Dourado, Noah G. Shuart, Sophia Lin, Clint Young, Zhiwei Xie, Kuldip Khakh, Elaine Chang, Luis E. Sojo, Andrea Lindgren, Sultan Chowdhury, Shannon Decker, Michael Grimwood, Jean-Christophe Andrez, Christoph M. Dehnhardt, Jodie Pang, Jae H. Chang, Brian S. Safina, Daniel P. Sutherlin, James P. Johnson, Jr., David H. Hackos, C. Lee Robinette, Charles J. Cohen
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3133-3145 (2018)
Summary: Selective block of NaV1.7 promises to produce non-narcotic analgesic activity without motor or cognitive impairment. Several NaV1.7-selective blockers have been reported, but efficacy in animal pain models required high multiples of the IC50
Externí odkaz:
https://doaj.org/article/751235f9fe504fde8c6781b6215d87d8
Autor:
Brian S, Safina, Steven J, McKerrall, Shaoyi, Sun, Chien-An, Chen, Sultan, Chowdhury, Qi, Jia, Jun, Li, Alla Y, Zenova, Jean-Christophe, Andrez, Girish, Bankar, Philippe, Bergeron, Jae H, Chang, Elaine, Chang, Jun, Chen, Richard, Dean, Shannon M, Decker, Antonio, DiPasquale, Thilo, Focken, Ivan, Hemeon, Kuldip, Khakh, Amy, Kim, Rainbow, Kwan, Andrea, Lindgren, Sophia, Lin, Jonathan, Maher, Janette, Mezeyova, Dinah, Misner, Karen, Nelkenbrecher, Jodie, Pang, Rebecca, Reese, Shannon D, Shields, Luis, Sojo, Tao, Sheng, Henry, Verschoof, Matthew, Waldbrook, Michael S, Wilson, Zhiwei, Xie, Clint, Young, Tanja S, Zabka, David H, Hackos, Daniel F, Ortwine, Andrew D, White, J P, Johnson, C Lee, Robinette, Christoph M, Dehnhardt, Charles J, Cohen, Daniel P, Sutherlin
Publikováno v:
Journal of medicinal chemistry. 64(6)
Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d744b2a5894fa87236be1caf92c75b8b
https://pubmed.ncbi.nlm.nih.gov/33682420
https://pubmed.ncbi.nlm.nih.gov/33682420
Autor:
Lisa K. Blum, Cecelia I. Pearson, Laughing Bear Torrez Dulgeroff, Rishali Gadkari, Angela Luo, Andrew Luo, Jennifer E. Melrose, Jess L. Nolin, Hai Li, Arthur Lee, Matthew N. Zhou, Puneet Anand, Ganapathy Sarma, Karla A. Henning, Steven J. Chapin, Shelley E. Ackerman, Romas Kudirka, Yuyi Shen, Bruce Hug, Edith A. Perez, Marcin Kowanetz, Michael N. Alonso, Brian S. Safina, David Dornan, William G. Mallet
Publikováno v:
Cancer Research. 82:2911-2911
Introduction: Immune-stimulating antibody conjugates (ISACs) direct a TLR7/8 agonist into tumors through engagement of cell surface antigens to activate tumor-associated myeloid cells and initiate a broad innate and adaptive anti-tumor immune respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::050815ec20aebbbb637033acbc3a563a
https://doi.org/10.1158/1538-7445.am2022-2911
https://doi.org/10.1158/1538-7445.am2022-2911
Autor:
Justin A. Kenkel, Rishali Gadkari, Po Y. Ho, Lisa K. Blum, Romas Kudirka, Karla A. Henning, William G. Mallet, Jennifer E. Melrose, Ganapathy Sarma, Steven J. Chapin, Matthew Zhou, Suprit Deol, Cindy Kreder, Yuyi Shen, Bruce Hug, Puneet Anand, Arthur Lee, Hai Li, Shelley E. Ackerman, Brian S. Safina, David Dornan, Michael N. Alonso, Marcin Kowanetz
Publikováno v:
Cancer Research. 82:4252-4252
INTRODUCTION: Immune-stimulating antibody conjugates (ISACs) consist of tumor-targeting antibodies conjugated to immune stimulants and are designed to activate the innate and adaptive immune systems against tumor cells following systemic administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dbf4f693cc6d47982df7afbd2d099b5
https://doi.org/10.1158/1538-7445.am2022-4252
https://doi.org/10.1158/1538-7445.am2022-4252
Autor:
Steven J, McKerrall, Teresa, Nguyen, Kwong Wah, Lai, Philippe, Bergeron, Lunbin, Deng, Antonio, DiPasquale, Jae H, Chang, Jun, Chen, Tania, Chernov-Rogan, David H, Hackos, Jonathan, Maher, Daniel F, Ortwine, Jodie, Pang, Jian, Payandeh, William R, Proctor, Shannon D, Shields, Jennifer, Vogt, Pengfei, Ji, Wenfeng, Liu, Elisa, Ballini, Lilia, Schumann, Glauco, Tarozzo, Girish, Bankar, Sultan, Chowdhury, Abid, Hasan, J P, Johnson, Kuldip, Khakh, Sophia, Lin, Charles J, Cohen, Christoph M, Dehnhardt, Brian S, Safina, Daniel P, Sutherlin
Publikováno v:
Journal of medicinal chemistry. 62(8)
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::353b137470888081de078c0141a07409
https://pubmed.ncbi.nlm.nih.gov/30943032
https://pubmed.ncbi.nlm.nih.gov/30943032
Autor:
Shaoyi, Sun, Qi, Jia, Alla Y, Zenova, Michael S, Wilson, Sultan, Chowdhury, Thilo, Focken, Jun, Li, Shannon, Decker, Michael E, Grimwood, Jean-Christophe, Andrez, Ivan, Hemeon, Tao, Sheng, Chien-An, Chen, Andy, White, David H, Hackos, Lunbin, Deng, Girish, Bankar, Kuldip, Khakh, Elaine, Chang, Rainbow, Kwan, Sophia, Lin, Karen, Nelkenbrecher, Benjamin D, Sellers, Antonio G, DiPasquale, Jae, Chang, Jodie, Pang, Luis, Sojo, Andrea, Lindgren, Matthew, Waldbrook, Zhiwei, Xie, Clint, Young, James P, Johnson, C Lee, Robinette, Charles J, Cohen, Brian S, Safina, Daniel P, Sutherlin, Daniel F, Ortwine, Christoph M, Dehnhardt
Publikováno v:
Journal of medicinal chemistry. 62(2)
Herein, we report the discovery and optimization of a series of orally bioavailable acyl sulfonamide Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::038f23a54877cc0c450b0a4b2689f99c
https://pubmed.ncbi.nlm.nih.gov/30499663
https://pubmed.ncbi.nlm.nih.gov/30499663
Autor:
Thilo, Focken, Sultan, Chowdhury, Alla, Zenova, Michael E, Grimwood, Christine, Chabot, Tao, Sheng, Ivan, Hemeon, Shannon M, Decker, Michael, Wilson, Paul, Bichler, Qi, Jia, Shaoyi, Sun, Clint, Young, Sophia, Lin, Samuel J, Goodchild, Noah G, Shuart, Elaine, Chang, Zhiwei, Xie, Bowen, Li, Kuldip, Khakh, Girish, Bankar, Matthew, Waldbrook, Rainbow, Kwan, Karen, Nelkenbrecher, Parisa, Karimi Tari, Navjot, Chahal, Luis, Sojo, C Lee, Robinette, Andrew D, White, Chien-An, Chen, Yi, Zhang, Jodie, Pang, Jae H, Chang, David H, Hackos, J P, Johnson, Charles J, Cohen, Daniel F, Ortwine, Daniel P, Sutherlin, Christoph M, Dehnhardt, Brian S, Safina
Publikováno v:
Journal of medicinal chemistry. 61(11)
The sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41b8d0a60c84d4f1a2c37587e6288037
https://pubmed.ncbi.nlm.nih.gov/29737846
https://pubmed.ncbi.nlm.nih.gov/29737846
Autor:
Girish, Bankar, Samuel J, Goodchild, Sarah, Howard, Karen, Nelkenbrecher, Matthew, Waldbrook, Michelle, Dourado, Noah G, Shuart, Sophia, Lin, Clint, Young, Zhiwei, Xie, Kuldip, Khakh, Elaine, Chang, Luis E, Sojo, Andrea, Lindgren, Sultan, Chowdhury, Shannon, Decker, Michael, Grimwood, Jean-Christophe, Andrez, Christoph M, Dehnhardt, Jodie, Pang, Jae H, Chang, Brian S, Safina, Daniel P, Sutherlin, James P, Johnson, David H, Hackos, C Lee, Robinette, Charles J, Cohen
Publikováno v:
Cell reports. 24(12)
Selective block of Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24df3eb486dfed5a4642cc263e273e3f
https://pubmed.ncbi.nlm.nih.gov/30231997
https://pubmed.ncbi.nlm.nih.gov/30231997
Publikováno v:
Angewandte Chemie (International ed. in English). 41(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1dee12f72c4d8def565f805da99ba840
https://pubmed.ncbi.nlm.nih.gov/19750639
https://pubmed.ncbi.nlm.nih.gov/19750639
Publikováno v:
Angewandte Chemie (International ed. in English). 41(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4f1456532c4234373f62bacdcd0a40d
https://pubmed.ncbi.nlm.nih.gov/19750640
https://pubmed.ncbi.nlm.nih.gov/19750640