Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Brian S, Hickory"'
Autor:
Dean Messing, Brian S. Hickory, Alan G. Benson, Matthew J. Saabye, Jeff Hitchcock, Heather M. Madsen, Devadas Balekudru, Shaun R. Selness, Richard C. Durley, Laura D. Marrufo, Gary D. Anderson, Li Xing, Kevin D. Jerome, Michael Hepperle, Christie Lance Christopher, Rajesh V. Devraj, Elizabeth G. Webb, Thomas Owen, Ravi G. Kurumbail, Edgardo Alvira, Jeffrey L. Hirsch, Joseph B. Monahan, Paul V. Rucker, Boehm Terri L, Blevis-Bal Radhika M, Huey S. Shieh, John K. Walker, John F. Schindler, Michele A. Promo, Win Naing, Sheri L. Bonar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4059-4065
A series of N-aryl pyridinone inhibitors of p38 mitogen activated protein (MAP) kinase were designed and prepared based on the screening hit SC-25028 (1) and structural comparisons to VX-745 (5). The focus of the investigation targeted the dependence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57328f6e5ea96fc972d684f2e92281c
https://doi.org/10.1016/j.bmcl.2011.04.120
https://doi.org/10.1016/j.bmcl.2011.04.120
Autor:
Jane L. Wang, Michael B. Tollefson, Margaret L. Grapperhaus, James A. Sikorski, Richard C. Durley, Monica B. Norton, Michele A. Promo, Michele A. Melton, Mark A. Massa, Emily J. Reinhard, Brian S. Hickory, William F. Vernier, Mark E. Smith, Yvette M. Fobian, Karen Regina, Bryan J. Witherbee, Daniel T. Connolly
Publikováno v:
Journal of Medicinal Chemistry. 46:2152-2168
A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b10e457203bbb1110208e3911dfa6aac
https://doi.org/10.1021/jm020528+
https://doi.org/10.1021/jm020528+
Autor:
Michele A Melton, Nigam P. Rath, Ming Zeng, Margaret L. Grapperhaus, Brian S Hickory, Jane L Wang, Elaine S. Krul, Deborah M. Heuvelman, Mark E. Smith, Kevin C. Glenn, Richard C Durley, Deborah A. Mischke, Bryan J. Witherbee, Daniel T. Connolly, Dale P Spangler, Dorothy D. Honda, Yvette M. Fobian, James A. Sikorski, Mark A. Massa, Barry L. Parnas
Publikováno v:
Journal of Medicinal Chemistry. 45:3891-3904
A novel series of substituted N-benzyl-N-phenyl-trifluoro-3-amino-2-propanols are described that reversibly inhibit cholesteryl ester transfer protein (CETP). Starting with screening lead 22, various structural features were explored with respect to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054e4cc40c00d2928100cc032ffe6208
https://doi.org/10.1021/jm020038h
https://doi.org/10.1021/jm020038h
Autor:
Mark E. Smith, Daniel T. Connolly, Bryan J. Witherbee, Brian S. Hickory, James A. Sikorski, Mark A. Massa, Richard C. Durley, Dale P. Spangler
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2882dc12eb3e273cdd24398b8cf730d9
https://doi.org/10.1002/chin.200147090
https://doi.org/10.1002/chin.200147090
Autor:
Emily J, Reinhard, Jane L, Wang, Richard C, Durley, Yvette M, Fobian, Margaret L, Grapperhaus, Brian S, Hickory, Mark A, Massa, Monica B, Norton, Michele A, Promo, Michael B, Tollefson, William F, Vernier, Daniel T, Connolly, Bryan J, Witherbee, Michele A, Melton, Karen J, Regina, Mark E, Smith, James A, Sikorski
Publikováno v:
Journal of medicinal chemistry. 46(11)
A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d9119f562ad78addf9a4a9fd8706b8e
https://pubmed.ncbi.nlm.nih.gov/12747787
https://pubmed.ncbi.nlm.nih.gov/12747787
Autor:
Brian S. Hickory, Richard C. Durley, James A. Sikorski, Mark A. Massa, Mark E. Smith, Bryan J. Witherbee, Dale P. Spangler, Daniel T. Connolly
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(13)
A series of novel N,N-disubstituted trifluoro-3-amino-2-propanols has been prepared as potent inhibitors of cholesteryl ester transfer protein (CETP). Modifying the aromatic 3-tetrafluoroethoxy group in the lead molecule 1a with various heteroaryl mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cec2ae537b038bd8e7cd5a16dad966f
https://pubmed.ncbi.nlm.nih.gov/11425523
https://pubmed.ncbi.nlm.nih.gov/11425523