Výsledky vyhledávání - "Brian Rossmiller"

Akademický článek

Systematic review and meta-analysis of the association between complement factor H I62V polymorphism and risk of polypoidal choroidal vasculopathy in Asian populations.

Autor: Zhao-Yang Wang, Keke Zhao, Jingwei Zheng, Brian Rossmiller, Cristhian Ildefonso, Manas Biswal, Pei-quan Zhao

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88324 (2014)

PurposeTo investigate whether the polymorphism rs800292 (184G>A, I62V) in the complement factor H gene is associated with polypoidal choroidal vasculopathy (PCV) and the genetic difference between PCV and neovascular age-related macular degeneration

Externí odkaz: https://doaj.org/article/d60e07cefae04e3bb5a036c1a7b5c13f

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Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector

Autor: Gustavo D. Aguirre, Alfred S. Lewin, Valerie L. Dufour, Artur V. Cideciyan, Raghavi Sudharsan, Luis Felipe Marinho, Tatyana Appelbaum, Michael T. Massengill, Brian Rossmiller, Alexander Sumaroka, Malgorzata Swider, William W. Hauswirth, Brianna Lisi, William A. Beltran, Samuel G. Jacobson, Simone Iwabe

Publikováno v: Proceedings of the National Academy of Sciences. 115

Inherited retinal degenerations are caused by mutations in >250 genes that affect photoreceptor cells or the retinal pigment epithelium and result in vision loss. For autosomal recessive and X-linked retinal degenerations, significant progress has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eca7219c7b0e4ffdb28c9f9bad3a6be
https://doi.org/10.1073/pnas.1805055115

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Long-Term Rescue of Retinal Structure and Function by Rhodopsin RNA Replacement with a Single Adeno-Associated Viral Vector in P23HRHOTransgenic Mice

Autor: Haoyu Mao, Alfred S. Lewin, William W. Hauswirth, Brian Rossmiller, Marina S. Gorbatyuk

Publikováno v: Human Gene Therapy. 23:356-366

Many mutations in the human rhodopsin gene (RHO) cause autosomal dominant retinitis pigmentosa (ADRP). Our previous studies with a P23H (proline-23 substituted by histidine) RHO transgenic mouse model of ADRP demonstrated significant improvement of r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b4a0ae3336542279b04cff553b61c4
https://doi.org/10.1089/hum.2011.213

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Four-port bimanual 23-gauge vitrectomy for diabetic tractional retinal detachment

Autor: Brian Rossmiller, Zhao-Yang Wang, Ke-Ke Zhao, Peiquan Zhao, Jia-kai Li

Publikováno v: Acta ophthalmologica. 94(4)

Purpose Four-port bimanual vitrectomy is a surgical technique that facilitates removal of epiretinal membranes in severe proliferative diabetic retinopathy (PDR). As the illumination is held by the assistant through the fourth scleral incision, fibro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df7d9fd9f53317a8dc6024a0222f561
https://pubmed.ncbi.nlm.nih.gov/26855122

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132. Gene Therapy With Self-Complementary Recombinant Adeno-Associated Virus in Models of Autosomal Dominant Retinitis Pigmentosa Cause by RHO Mutations

Autor: Lewin Alfred, Hiral Jivanji, Arathi Nandyala, Danny Zakria, Brian Rossmiller

Publikováno v: Molecular Therapy. 23

Retinitis pigmentosa is the leading hereditary cause of blindness with 30-40% of cases attributable to autosomal dominant retinitis pigmentosa (ADRP). ADRP arises from mutations in at least 24 known genes with 30% arising in the rhodopsin gene (RHO).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab153bea6c341f943bad4c76ff51d57a

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Gene therapy to rescue retinal degeneration caused by mutations in rhodopsin

Autor: Brian Rossmiller, Renee C. Ryals, Alfred S. Lewin

Publikováno v: Methods in Molecular Biology ISBN: 9781493923298

Retinal gene therapy has proven safe and at least partially successful in clinical trials and in numerous animal models. Gene therapy requires characterization of the progression of the disease and understanding of its genetic cause. Testing gene the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f3517f15a804534673595db4f387a7
https://pubmed.ncbi.nlm.nih.gov/25697537

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Gene augmentation for adRP mutations in RHO

Autor: Brian Rossmiller, Haoyu Mao, Alfred S. Lewin

Publikováno v: Cold Spring Harbor perspectives in medicine. 4(9)

As many as 40% of retinitis pigmentosa cases display autosomal dominant inheritance, and approximately one quarter of these are attributable to mutations in RHO, the gene for rod cell opsin (Sullivan et al. 2006). A complicating feature of RHO-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa66f018904e949934756ae4b99e551
https://pubmed.ncbi.nlm.nih.gov/25037104

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Systematic Review and Meta-Analysis of the Association between Complement Factor H I62V Polymorphism and Risk of Polypoidal Choroidal Vasculopathy in Asian Populations

Autor: Peiquan Zhao, Manas R. Biswal, Brian Rossmiller, Zhao-Yang Wang, Cristhian J Ildefonso, Jingwei Zheng, Ke-Ke Zhao

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88324 (2014)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05218a2633b8da5c4f3aafb0b8b562d8
https://doi.org/10.1371/journal.pone.0088324

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