Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Brian Roland, Larsen"'
Autor:
Helle S. Waagepetersen, Trine Lisberg Toft-Bertelsen, Brian Roland Larsen, Nanna MacAulay, Himanshu Khandelia, Sofie K. Christensen
Publikováno v:
Toft-Bertelsen, T L, Larsen, B R, Christensen, S K, Khandelia, H, Waagepetersen, H S & MacAulay, N 2021, ' Clearance of activity-evoked K + transients and associated glia cell swelling occur independently of AQP4 : A study with an isoform-selective AQP4 inhibitor ', Glia, vol. 69, no. 1, pp. 28-41 . https://doi.org/10.1002/glia.23851
Toft-Bertelsen, T L, Larsen, B R, Christensen, S K, Khandelia, H, Waagepetersen, H S & MacAulay, N 2020, ' Clearance of activity-evoked K + transients and associated glia cell swelling occur independently of AQP4 : A study with an isoform-selective AQP4 inhibitor ', Glia, vol. 69, no. 1, pp. 28-41 . https://doi.org/10.1002/glia.23851
Toft-Bertelsen, T L, Larsen, B R, Christensen, S K, Khandelia, H, Waagepetersen, H S & MacAulay, N 2020, ' Clearance of activity-evoked K + transients and associated glia cell swelling occur independently of AQP4 : A study with an isoform-selective AQP4 inhibitor ', Glia, vol. 69, no. 1, pp. 28-41 . https://doi.org/10.1002/glia.23851
The mammalian brain consists of 80% water, which is continuously shifted between different compartments and cellular structures by mechanisms that are, to a large extent, unresolved. Aquaporin 4 (AQP4) is abundantly expressed in glia and ependymal ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f1b1389cee28e679c7dca53b89249a
https://findresearcher.sdu.dk:8443/ws/files/170699440/glia.23851.pdf
https://findresearcher.sdu.dk:8443/ws/files/170699440/glia.23851.pdf
Autor:
Trine Lisberg, Toft-Bertelsen, Brian Roland, Larsen, Sofie Kjellerup, Christensen, Himanshu, Khandelia, Helle S, Waagepetersen, Nanna, MacAulay
Publikováno v:
GliaREFERENCES. 69(1)
The mammalian brain consists of 80% water, which is continuously shifted between different compartments and cellular structures by mechanisms that are, to a large extent, unresolved. Aquaporin 4 (AQP4) is abundantly expressed in glia and ependymal ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::080a8d37c9c6cbe5c1a921e99b371379
https://pubmed.ncbi.nlm.nih.gov/32506554
https://pubmed.ncbi.nlm.nih.gov/32506554
Publikováno v:
The Journal of Physiology. 597:583-597
KEY POINTS Neuronal activity induces fluctuation in extracellular space volume, [K+ ]o and pHo , the management of which influences neuronal function The neighbour astrocytes buffer the K+ and pH and swell during the process, causing shrinkage of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f077a591f46fe2d43d4e0a4f838b02e8
https://doi.org/10.1113/jp276768
https://doi.org/10.1113/jp276768
Publikováno v:
Channels
Toft-Bertelsen, T L, Larsen, B R & MacAulay, N 2018, ' Sensing and regulation of cell volume-we know so much and yet understand so little : TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role? ', Channels (Austin), vol. 12, no. 1, pp. 100-108 . https://doi.org/10.1080/19336950.2018.1438009
Toft-Bertelsen, T L, Larsen, B R & MacAulay, N 2018, ' Sensing and regulation of cell volume-we know so much and yet understand so little : TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role? ', Channels (Austin), vol. 12, no. 1, pp. 100-108 . https://doi.org/10.1080/19336950.2018.1438009
Cellular volume changes lead to initiation of cell volume regulatory events, the molecular identity of which remains unresolved. We here discuss experimental challenges associated with investigation of volume regulation during application of large, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4cd0e3f73434df71ccce920b240585
http://europepmc.org/articles/PMC5972811
http://europepmc.org/articles/PMC5972811
Autor:
Brian Roland Larsen, Michelle L. Olsen, Rikke Holm, Nanna MacAulay, Leanne M. Holt, Karin Lykke-Hartmann, Anca Stoica, Mette Assentoft, Bente Vilsen, Frederik Vilhardt
Publikováno v:
Stoica, A, Larsen, B, Assentoft, M, Jensen, R H, Holt, L, Vilhardt, F, Vilsen, B, Lykke-Hartmann, K & MacAulay, N 2017, ' The α2β2 isoform combination dominates the astrocytic Na+ /K+-ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation. ', Glia, vol. 65, no. 11, pp. 1777-1793 . https://doi.org/10.1002/glia.23194
Synaptic activity results in transient elevations in extracellular K+ , clearance of which is critical for sustained function of the nervous system. The K+ clearance is, in part, accomplished by the neighboring astrocytes by mechanisms involving the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43528804b25db705b2078a10ffcb480
https://doi.org/10.1002/glia.23194
https://doi.org/10.1002/glia.23194
Autor:
Brian Roland Larsen, Nanna MacAulay
Publikováno v:
Glia. 65:1668-1681
During neuronal activity in the mammalian brain, the K+ released into the synaptic space is initially buffered by the astrocytic compartment. In parallel, the extracellular space (ECS) shrinks, presumably due to astrocytic cell swelling. With the Na+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::806f1b13593093b739fb4efec8de4527
https://doi.org/10.1002/glia.23187
https://doi.org/10.1002/glia.23187
Publikováno v:
The Journal of Physiology. 594:6627-6641
KEY POINTS Management of glutamate and K+ in brain extracellular space is of critical importance to neuronal function. The astrocytic α2β2 Na+ /K+ -ATPase isoform combination is activated by the K+ transients occurring during neuronal activity. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::688c53a1ae1fb9e0c85ca0c47a2f0155
https://doi.org/10.1113/jp272531
https://doi.org/10.1113/jp272531
Publikováno v:
The Journal of physiology. 597(2)
KEY POINTS: Neuronal activity induces fluctuation in extracellular space volume, [K(+)](o) and pH(o), the management of which influences neuronal function. The neighbour astrocytes buffer the K(+) and pH and swell during the process, causing shrinkag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a23a51320b4e1147464d6bea0589ca9a
https://pubmed.ncbi.nlm.nih.gov/30357826
https://pubmed.ncbi.nlm.nih.gov/30357826
Publikováno v:
Neurochemical Research. 40:2615-2627
Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c51aaeb36510ae3f060bb983e60f70d
https://doi.org/10.1007/s11064-015-1519-z
https://doi.org/10.1007/s11064-015-1519-z
Autor:
Brian Roland Larsen, Anca Stoica, Mette Assentoft, Rikke Holm Jensen, Holt, Leanne M., Karin Lykke-Hartmann, Olsen, Michelle L., Bente Vilsen, Nanna MacAulay
Publikováno v:
Larsen, B R, Stoica, A, Assentoft, M, Jensen, R H, Holt, L M, Lykke-Hartmann, K, Olsen, M L, Vilsen, B & MacAulay, N 2017, ' Astrocytic Na,K-ATPase a2b1 and a2b2 manages [K+]o differently during synaptic activity. Poster at the 15th International Conference on Na,K-ATPase and Related Transport ATPases, Otsu, Japan, 2017 ' .
Aarhus University
Aarhus University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6dc0cf865474523ecc1705c995ab591c
https://pure.au.dk/portal/da/publications/astrocytic-nakatpase-a2b1-and-a2b2-manages-ko-differently-during-synaptic-activity-poster-at-the-15th-international-conference-on-nakatpase-and-related-transport-atpases-otsu-japan-2017(29dd31f1-0c06-431f-81a7-869204a3d123).html
https://pure.au.dk/portal/da/publications/astrocytic-nakatpase-a2b1-and-a2b2-manages-ko-differently-during-synaptic-activity-poster-at-the-15th-international-conference-on-nakatpase-and-related-transport-atpases-otsu-japan-2017(29dd31f1-0c06-431f-81a7-869204a3d123).html