Výsledky vyhledávání - "Brian R. de Costa"

Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting σ1 receptors produce anti-cocaine effects in mice

Autor: Michele J Friedman, Buddy Pouw, Brian R. de Costa, Wayne D. Bowen, Kari A. McCracken, Rae R. Matsumoto

Publikováno v: European Journal of Pharmacology. 419:163-174

Cocaine's ability to interact with sigma receptors suggests that these proteins mediate some of its behavioral effects. Therefore, three novel sigma receptor ligands with antagonist activity were evaluated in Swiss Webster mice: BD1018 (3S-1-[2-(3,4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfed305305303566aa4c3a4fc0a6e73
https://doi.org/10.1016/s0014-2999(01)00968-2

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Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity

Autor: Rae R. Matsumoto, Wayne D. Bowen, Kari A. McCracken, Brian R. de Costa

Publikováno v: European Journal of Pharmacology. 370:225-232

The ability of cocaine to interact with sigma receptors indicates that these sites may mediate the negative properties associated with cocaine use, such as toxicity and addiction. Previous studies have shown that the novel sigma receptor ligand, BD10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34ef8553fbde5f65ad71c1faf590649
https://doi.org/10.1016/s0014-2999(99)00113-2

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Subchronic administration of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine (BD1047) alters σ1 receptor binding

Autor: Brian R. de Costa, Alexander C. Zambon, Bang (John) Q.H Nguyen, Anumantha G. Kanthasamy, Rae R. Matsumoto

Publikováno v: European Journal of Pharmacology. 324:39-47

BD1047 (N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine) is known to bind with high affinity and selectivity to sigma sites in vitro. In prior in vivo studies, it has been shown to attenuate the dystonic postures and orofacial dy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7962d7f3706598a0a255c0b2a511374
https://doi.org/10.1016/s0014-2999(97)00053-8

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Dissociation of the motor effects of (+)-pentazocine from binding to σ1 sites

Autor: Wayne D. Bowen, Brian R. de Costa, J. Michael Walker, Daniel D. Truong, Saundra L. Patrick, Kenner C. Rice, Alexander C. Zambon, Van Nhi Vo, Rae R. Matsumoto

Publikováno v: European Journal of Pharmacology. 301:31-40

Radioligand binding and behavioral studies were conducted to determine whether a relationship existed between the motor effects produced by (+)-pentazocine and its binding to σ sites. Scatchard analyses revealed decreased [ 3 H](+)-pentazocine bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00f9e4e098586d29642cc29fd143e07
https://doi.org/10.1016/0014-2999(96)00008-8

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Dihydrocodeinone-hydrazone, dihydrocodeinone-oxime, naloxone-3-ome-oxime, and clocinnamox fail to irreversibly inhibit opioid kappa receptor binding

Autor: Richard B. Rothman, Heng Xu, J. S. Partilla, Anna Borsodi, Brian R. de Costa, Kenner C. Rice, Qing Ni, Sándor Hosztafi

Publikováno v: Neurochemical Research. 19:1159-1163

Previous work from our lab identified two subtypes of the opioid kappa receptor. Whereas the kappa1 receptor can be labeled by [3H]U69,593 (5α, 7α, 8β-(−)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro (4,5)dec-8-yl]-phenyl-benzeneacetamide), the kap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7a6a57ef848f7a88c3c3bc80357536
https://doi.org/10.1007/bf00965150

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A Study of the Effect of Catalyst on Stereochemistry in the Hydrogenation of N-(Menthyloxycarbonyl)-N-Methyl-2-(N-Pyrrolidinyl)-1-cyclohexenamine

Autor: Dorota Matecka, Brian R. de Costa

Publikováno v: Synthetic Communications. 24:1531-1540

Catalytic hydrogenation of N-(menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)-1-cyclohexenamine (3) gave mainly 1R,2S-cis-N-(menthyloxycarbonyl)- and 1S,2R-cis-N-(menthyloxycarbonyl)-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines 7 and 8 with diastereos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31b38e5714b761eb66c7f6b9a0a0fde0
https://doi.org/10.1080/00397919408010153

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Synthesis of [123I]tert-butyl 8-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate, a potential SPECT imaging agent for diazepam-insensitive (DI) benzodiazepine receptors

Autor: Kan Sam Lee, Dorota Matecka, Garry Wong, Brian R. de Costa, Xiao-shu He, Kenner C. Rice, Zi-Qiang Gu, Phil Skolnick

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 34:27-32

[123I]tert-Butyl 8-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo [1,5-a][1,4]benzodiazepine 3-carboxylate ([123I]3), a high affinity and selective radioligand for the diazepam insensitive (DI) benzodiazepine receptor was synthesized in 2 steps from tert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::223621af6e4d19daf1234cb896b94df7
https://doi.org/10.1002/jlcr.2580340105

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Low affinity of FMRFamide and four FaRPs (FMRFamide-related peptides), including the mammalian-derived FaRPs F-8-Famide (NPFF) and A-18-Famide, for opioid μ, δ, , , or receptors

Autor: Robert B. Raffa, Andrew Kim, Ellen E. Codd, Brian R. de Costa, Richard B. Rothman, Kenner C. Rice

Publikováno v: Peptides. 15:401-404

The binding affinities at opioid receptor subtypes in rat or guinea pig brain membranes were determined for the neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2), the two mammalian-derived FMRFamide-related peptides F-8-Famide (NPFF; Phe-Leu-Phe-Gln-Pro-G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45a433de394221c07f20c81cadfaa890
https://doi.org/10.1016/0196-9781(94)90195-3

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Differential binding of opioid peptides and other drugs to two subtypes of opioid binding sites in mouse brain: Further evidence for δ receptor heterogeneity

Autor: Kenner C. Rice, Heng Xu, Brian R. de Costa, Richard B. Rothman, J. S. Partilla

Publikováno v: Peptides. 14:893-907

Research into the functional role of the opioid δ receptor has intensified with the recent in vivo identification of δ receptor subtypes, termed δ 1 and δ 2 , which mediate antinociception in the mouse. A variety of data also support the hypothes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfb9953854a10518aa59f89379896b3
https://doi.org/10.1016/0196-9781(93)90064-n

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