Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Brian R. Younge"'
Autor:
Kenneth J. Warrington, Jörg J. Goronzy, John Fritzlen, Joseph J. Maleszewski, Gene G. Hunder, Cornelia M. Weyand, Brian R. Younge
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
While clinical signs and symptoms of giant cell arter it is improve promptly after starting glucocorticoid therapy, reports have suggested that the vascular inflammation may persist. To assess the duration and quality of his to pathologic changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7806e386909ed3a1f262a56e1da095ce
http://europepmc.org/articles/PMC5650068
http://europepmc.org/articles/PMC5650068
Autor:
Aki Kawasaki, Dan Boghen, Brian R. Younge, Robert K. Shin, Luis J. Mejico, Mark L. Moster, Valerie A. Purvin
Publikováno v:
Journal of Neuro-Ophthalmology. 35:139-143
BACKGROUND Cranial nerve schwannomas are radiologically characterized by nodular cranial nerve enhancement on magnetic resonance imaging (MRI). Schwannomas typically present with gradually progressive symptoms, but isolated reports have suggested tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7d895ce25fc7e7283c79b3e9b3ba38
https://doi.org/10.1097/wno.0000000000000220
https://doi.org/10.1097/wno.0000000000000220
Autor:
Manisha Desai, Cornelia M. Weyand, Jessica Kubo, Jiusheng Deng, Brian R. Younge, Kisha Piggott, Kenneth J. Warrington, Jörg J. Goronzy
Publikováno v:
Circulation. 123:309-318
Background— Giant cell arteritis is a granulomatous vasculitis of the aorta and its branches that causes blindness, stroke, and aortic aneurysm. CD4 T cells are key pathogenic regulators, instructed by vessel wall dendritic cells to differentiate i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5fa1e653d87fc14c285a8174e87657
https://doi.org/10.1161/circulationaha.110.936203
https://doi.org/10.1161/circulationaha.110.936203
Publikováno v:
Current Opinion in Rheumatology. 23:43-49
Granuloma formation in giant cell arteritis (GCA) emphasizes the role of adaptive immunity and highlights the role of antigen-specific T cells. Recent data demonstrate that at least two separate lineages of CD4 T cells participate in vascular inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5650c88403e830bec858ea7d289d77fb
https://doi.org/10.1097/bor.0b013e32833ee946
https://doi.org/10.1097/bor.0b013e32833ee946
Publikováno v:
Current Opinion in Lipidology. 19:469-477
Inflammatory vasculopathies, spanning from atherosclerosis to vasculitides, are driven by innate and adaptive immune responses. Instructed by antigen-presenting cells, T cells have unsurpassed skills to orchestrate protective and pathogenic immunity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3c1d2f43e779dbdcfca9a5fbbfb0eb
https://doi.org/10.1097/mol.0b013e32830bfdc2
https://doi.org/10.1097/mol.0b013e32830bfdc2
Publikováno v:
Journal of Neuro-Ophthalmology. 27:107-114
BACKGROUND Ophthalmoscopy of the fundus in a patient with head tremor is facilitated by image stability, whereas such observation of a patient with nystagmus is made difficult by image movement. Why does this occur? METHODS We offer an explanation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80bdaf02cc9a2405e2b25a7f1ce228b
https://doi.org/10.1097/wno.0b013e318064e516
https://doi.org/10.1097/wno.0b013e318064e516
Autor:
Kirk A. Easley, Kenneth T. Calamia, Mehrdad Mazlumzadeh, Brian R. Younge, Eric L. Matteson, Cornelia M. Weyand, Gene G. Hunder, Jörg J. Goronzy, W. Leroy Griffing
Publikováno v:
Arthritis & Rheumatism. 54:3310-3318
Objective Glucocorticoid (GC) therapy for giant cell arteritis (GCA) is effective but requires prolonged administration, resulting in adverse side effects. The goal of the current study was to test the hypothesis that induction treatment with high-do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b382b73cb194a1850855dd0372ac67d
https://doi.org/10.1002/art.22163
https://doi.org/10.1002/art.22163
Autor:
Jacqueline A. Leavitt, Brian R. Younge
Publikováno v:
Journal of Neuro-Ophthalmology. 24:337-343
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0b46d2ac683cf6be8928f8b7b8a6a4
https://doi.org/10.1097/00041327-200412000-00013
https://doi.org/10.1097/00041327-200412000-00013
Autor:
Jörg J. Goronzy, Cornelia M. Weyand, Luke I. Szweda, Brian R. Younge, Astrid Borkowski, Bettina Mock, Johannes Bjornsson, Kerstin Moeller
Publikováno v:
The American Journal of Pathology. 161:115-123
Arterial wall damage in giant cell arteritis (GCA) is mediated by several different macrophage effector functions, including the production of metalloproteinases and lipid peroxidation. Tissue-invading macrophages also express nitric oxide synthase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28c689f7ea36b1b973332625895a7a3b
https://doi.org/10.1016/s0002-9440(10)64163-6
https://doi.org/10.1016/s0002-9440(10)64163-6
Publikováno v:
Arthritis & Rheumatism. 46:457-466
Objective In giant cell arteritis (GCA), inflammatory lesions typically produce interferon-γ (IFNγ)– and nuclear factor κB (NF-κB)–dependent monokines. Corticosteroids influence disease activity by repressing NF-κB–dependent genes but have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b637bb6ccb9d33340b3cee64562763
https://doi.org/10.1002/art.10071
https://doi.org/10.1002/art.10071