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Autor:
Michael St. Pierre, Catherine Angela Hulford, David J. Bernhardson, Brian R. Preston, Benjamin A. Thuma, Peter H. Thompson, John F. Sagal, Kristin E. Price, Thomas Andrew Brandt, Lehner Richard S
Publikováno v:
Organic Process Research & Development. 18:57-65
The development and optimization of a scalable synthesis of sodium-dependent glucose cotransporter 2 inhibitor, ertugliflozin, for the treatment of type-2 diabetes is described. Highlights of the chemistry are a concise, four-step synthesis of a stru