Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Brian R. Duke"'
Autor:
Vijaya L. Simhadri, Louis Hopkins, Joseph R. McGill, Brian R. Duke, Swati Mukherjee, Kate Zhang, Zuben E. Sauna
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
There have been reports of immune responses against Cas9 which may impair clinical use. Here the authors scan a cohort comparable to the North American population vis-à-vis distribution of MHC-II variants to identify Cas9 peptides presented by MHC-I
Externí odkaz:
https://doaj.org/article/cfab9360e97b4aa380519906ce6d7273
Autor:
Louis B. Hopkins, Vijaya L. Simhadri, Zuben E. Sauna, Joseph R. McGill, Swati Mukherjee, Brian R Duke, Kate Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Nature Communications
Nature Communications
CRISPR–Cas9 mediated genome editing offers unprecedented opportunities for treating human diseases. There are several reports that demonstrate pre-existing immune responses to Cas9 which may have implications for clinical development of CRISPR-Cas9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aba8cdc6b0e10d71e6806169e15e4e8
https://doaj.org/article/cfab9360e97b4aa380519906ce6d7273
https://doaj.org/article/cfab9360e97b4aa380519906ce6d7273
Autor:
Brian R. Duke, Shibani Mitra-Kaushik
Publikováno v:
Journal of Pharmaceutical Innovation. 15:202-218
Biotherapeutics are a large and rapidly growing class of drugs being produced by pharmaceutical companies to treat a diverse range of clinical indications. The overall efficacy and safety of these products can be greatly impacted by their capacity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c90a2aa8cf793fd728bc491b19d4aa5d
https://doi.org/10.1007/s12247-019-09412-5
https://doi.org/10.1007/s12247-019-09412-5
Autor:
Brian D. Stadinski, Sydney J. Blevins, Nicholas A. Spidale, Brian R. Duke, Priya G. Huseby, Lawrence J. Stern, Eric S. Huseby
Publikováno v:
Nature Immunology. 20:1046-1058
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::234bb0acb6e5c29417c765d0c23f1378
https://doi.org/10.1038/s41590-019-0414-1
https://doi.org/10.1038/s41590-019-0414-1
Autor:
Brian D, Stadinski, Sydney J, Blevins, Nicholas A, Spidale, Brian R, Duke, Priya G, Huseby, Lawrence J, Stern, Eric S, Huseby
Publikováno v:
Nature immunology. 20(8)
The neonatal thymus generates Foxp3(+) regulatory T (tT(reg)) cells that are critical in controlling immune homeostasis and preventing multi-organ autoimmunity. The role of antigen specificity on neonatal tT(reg) cell selection is unresolved. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62ca4c496a93bc1f4c28fbfb83d28bcf
https://pubmed.ncbi.nlm.nih.gov/31209405
https://pubmed.ncbi.nlm.nih.gov/31209405
Autor:
Brian R Duke, Priya G. Huseby, Lawrence J. Stern, Brian D. Stadinski, Guoqi Li, Peter Trenh, Eric S. Huseby
Publikováno v:
The Journal of Immunology. 192:6071-6082
The mature T cell repertoire has the ability to orchestrate immunity to a wide range of potential pathogen challenges. This ability stems from thymic development producing individual T cell clonotypes that express TCRs with unique patterns of Ag reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0284ff131329a08380aa28ee2d7a6106
https://doi.org/10.4049/jimmunol.1303209
https://doi.org/10.4049/jimmunol.1303209