Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Brian R Jackson"'
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004771 (2015)
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), which are aggressive malignancies associated with immunocompromised patients. For many non-viral malignancies, therape
Externí odkaz:
https://doaj.org/article/7103d46cbca24aefb2f4dcc3fe649980
Autor:
Brandon S Walker, Richard E Nelson, Brian R Jackson, David G Grenache, Edward R Ashwood, Robert L Schmidt
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131402 (2015)
Non-invasive prenatal testing (NIPT) is a relatively new technology for diagnosis of fetal aneuploidies. NIPT is more accurate than conventional maternal serum screening (MSS) but is also more costly. Contingent NIPT may provide a cost-effective alte
Externí odkaz:
https://doaj.org/article/347481f0e2cf4fb0897a1c77fd98c77c
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004098 (2014)
Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic herpesvirus associated with multiple AIDS-related malignancies. Like other herpesviruses, KSHV has a biphasic life cycle and both the lytic and latent phases are required for tumorigenesi
Externí odkaz:
https://doaj.org/article/391cd6904f9c4152b3be77a521495b4d
Publikováno v:
Frontiers in Microbiology, Vol 3 (2012)
Post-transcriptional events which regulate mRNA biogenesis are fundamental to the control of gene expression. A nascent mRNA is therefore steered through multimeric RNA-protein complexes that mediate its capping, splicing, polyadenylation, nuclear ex
Externí odkaz:
https://doaj.org/article/5ec76a43510b45a19c4b220676cb6c32
Autor:
Brian R Jackson, James R Boyne, Marko Noerenberg, Adam Taylor, Guillaume M Hautbergue, Matthew J Walsh, Rachel Wheat, David J Blackbourn, Stuart A Wilson, Adrian Whitehouse
Publikováno v:
PLoS Pathogens, Vol 7, Iss 7, p e1002138 (2011)
The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly. Intriguingly however, depletion of Aly only leads to a modest reduction in cellular mRNA
Externí odkaz:
https://doaj.org/article/df7aad35cc464e7fad144adaa0311cf6
Autor:
Richard B Tunnicliffe, Guillaume M Hautbergue, Priti Kalra, Brian R Jackson, Adrian Whitehouse, Stuart A Wilson, Alexander P Golovanov
Publikováno v:
PLoS Pathogens, Vol 7, Iss 1, p e1001244 (2011)
The herpesvirus proteins HSV-1 ICP27 and HVS ORF57 promote viral mRNA export by utilizing the cellular mRNA export machinery. This function is triggered by binding to proteins of the transcription-export (TREX) complex, in particular to REF/Aly which
Externí odkaz:
https://doaj.org/article/ac4e817f93ff4970997e8f684b90d1df
Publikováno v:
Journal of Pathology Informatics, Vol 6, Iss 1, Pp 10-10 (2015)
Background: Laboratory utilization management describes a process designed to increase healthcare value by altering requests for laboratory services. A typical approach to monitor and prioritize interventions involves audits of laboratory orders agai
Externí odkaz:
https://doaj.org/article/00d23c964f65468784783e16d94da1b5
Autor:
Brian H Shirts, Brian R Jackson, Geoffrey S Baird, Jason M Baron, Bryan Clements, Ricky Grisson, Ronald George Hauser, Julie R Taylor, Enrique Terrazas, Brad Brimhall
Publikováno v:
Journal of Pathology Informatics, Vol 6, Iss 1, Pp 9-9 (2015)
The clinical laboratory is a major source of health care data. Increasingly these data are being integrated with other data to inform health system-wide actions meant to improve diagnostic test utilization, service efficiency, and "meaningful use." T
Externí odkaz:
https://doaj.org/article/2c5c47dff09745d4a438a0dd8de98156
Autor:
Jason M Baron, Anand S Dighe, Ramy Arnaout, Ulysses J Balis, W Stephen Black-Schaffer, Alexis B Carter, Walter H Henricks, John M Higgins, Brian R Jackson, JiYeon Kim, Veronica E Klepeis, Long P Le, David N Louis, Diana Mandelker, Craig H Mermel, James S Michaelson, Rakesh Nagarajan, Mihae E Platt, Andrew M Quinn, Luigi Rao, Brian H Shirts, John R Gilbertson
Publikováno v:
Journal of Pathology Informatics, Vol 5, Iss 1, Pp 2-2 (2014)
Background: Pathologists and informaticians are becoming increasingly interested in electronic clinical decision support for pathology, laboratory medicine and clinical diagnosis. Improved decision support may optimize laboratory test selection, impr
Externí odkaz:
https://doaj.org/article/e9e523c6e77f49aaa593b0a1b335c5b9
Publikováno v:
Journal of Pathology Informatics, Vol 4, Iss 1, Pp 33-33 (2013)
Background: Laboratory data can provide a wide range of information to estimate adherence to guidelines and proper utilization of genetic testing. The methylene tetrahydrofolate reductase (MTHFR) C677T variant has been demonstrated to have negligible
Externí odkaz:
https://doaj.org/article/90f8cc53d1d94ea7bd959bca4b629228