Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Brian R Hearn"'
Autor:
Ciara M Gallagher, Carolina Garri, Erica L Cain, Kenny Kean-Hooi Ang, Christopher G Wilson, Steven Chen, Brian R Hearn, Priyadarshini Jaishankar, Andres Aranda-Diaz, Michelle R Arkin, Adam R Renslo, Peter Walter
Publikováno v:
eLife, Vol 5 (2016)
The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for cells to survive ER stress. Activation of ATF6α promotes cell survival in cancer models. We used cell-based screens to di
Externí odkaz:
https://doaj.org/article/44b158715f4e4880ab40be484472e49b
Autor:
Carmela Sidrauski, Jordan C Tsai, Martin Kampmann, Brian R Hearn, Punitha Vedantham, Priyadarshini Jaishankar, Masaaki Sokabe, Aaron S Mendez, Billy W Newton, Edward L Tang, Erik Verschueren, Jeffrey R Johnson, Nevan J Krogan, Christopher S Fraser, Jonathan S Weissman, Adam R Renslo, Peter Walter
Publikováno v:
eLife, Vol 4 (2015)
The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the integrated stress response phosphorylate eIF2 serine-51, inhibiting nucleotide exchange by eIF2B. ISRIB, a potent drug-like smal
Externí odkaz:
https://doaj.org/article/12e8ad8456444891baa5b27de57a8417
Autor:
Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara M Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, Karim Nader, Michelle R Arkin, Adam R Renslo, Nahum Sonenberg, Peter Walter
Publikováno v:
eLife, Vol 2 (2013)
Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions activate different eIF2α kinases (PERK, PKR, GCN2, and HRI) that converge on phosphorylating
Externí odkaz:
https://doaj.org/article/8e9e1b8dba294563a7f482f53248b47c
Autor:
Christopher E Heise, Jeremy Murray, Katherine E Augustyn, Brandon Bravo, Preeti Chugha, Frederick Cohen, Anthony M Giannetti, Paul Gibbons, Rami N Hannoush, Brian R Hearn, Priyadarshini Jaishankar, Cuong Q Ly, Kinjalkumar Shah, Karen Stanger, Micah Steffek, Yinyan Tang, Xianrui Zhao, Joseph W Lewcock, Adam R Renslo, John Flygare, Michelle R Arkin
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50864 (2012)
Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases. We report the discovery and characterization of a potent inhibitor of caspase
Externí odkaz:
https://doaj.org/article/86e58beea90d4df59b4e81e29a6f24b6
Autor:
Daniel V. Santi, Gary W. Ashley, Ralph Reid, Brian R. Hearn, Henry F. VanBrocklin, Shaun D. Fontaine, Denis R. Beckford Vera
Synthetic procedures and supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b4d95813ac8d15d0aa6c8aeafa6b03
https://doi.org/10.1158/1535-7163.22520635.v1
https://doi.org/10.1158/1535-7163.22520635.v1
Autor:
Daniel V. Santi, Gary W. Ashley, Ralph Reid, Brian R. Hearn, Henry F. VanBrocklin, Shaun D. Fontaine, Denis R. Beckford Vera
The goal was to develop and characterize a companion diagnostic for the releasable PEG40kDa∼SN-38 oncology drug, PLX038, that would identify tumors susceptible to high accumulation of PLX038. PEG conjugates of the zirconium ligand desferroxamine B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526260949562b037552d54b4a520d6c1
https://doi.org/10.1158/1535-7163.c.6542710.v1
https://doi.org/10.1158/1535-7163.c.6542710.v1
Autor:
Erin C. Dueber, Priyadarshini Jaishankar, Adam R. Renslo, Charlene Bashore, Nicholas J. Skelton, Jakob Fuhrmann, Peter Liu, Brian R. Hearn
Publikováno v:
ACS Chemical Biology. 15:1392-1400
Ubiquitin specific protease 7 (USP7) regulates the protein stability of key cellular regulators in pathways ranging from apoptosis to neuronal development, making it a promising therapeutic target. Here we used an engineered, activated variant of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a217c97a2bdb0875c25fb27a7cdeee1
https://doi.org/10.1021/acschembio.0c00031
https://doi.org/10.1021/acschembio.0c00031
Autor:
Yannick Kraemer, Brian R. Hearn, Shaun D. Fontaine, Gary W. Ashley, Eric L. Schneider, Daniel V. Santi
Publikováno v:
Bioconjugate chemistry. 32(4)
β-Elimination of drugs tethered to macromolecular carbamates provides a platform for drug half-life extension. However, the macromolecular Michael acceptor products formed upon drug release can potentially react with biological amines and thiols and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138807a3020fb1925ca06910b6b15060
https://pubmed.ncbi.nlm.nih.gov/33822591
https://pubmed.ncbi.nlm.nih.gov/33822591
Publikováno v:
Engineering Reports, Vol 2, Iss 8, Pp n/a-n/a (2020)
The purpose of this work was to develop equipment and procedures for large‐scale aseptic production of injectable microsphere (MS) drug conjugates. The two major challenges were (a) to prepare sufficient amounts of MSs for clinical trials, and (b)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c188bf02820e6299edf49df93750bb53
https://doaj.org/article/3abdd76729364ad3bc0723af8bddf640
https://doaj.org/article/3abdd76729364ad3bc0723af8bddf640