Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Brian R Berridge"'
Autor:
Caterina Vacchi-Suzzi, Yasmina Bauer, Brian R Berridge, Sandrine Bongiovanni, Kevin Gerrish, Hisham K Hamadeh, Martin Letzkus, Jonathan Lyon, Jonathan Moggs, Richard S Paules, François Pognan, Frank Staedtler, Martin P Vidgeon-Hart, Olivier Grenet, Philippe Couttet
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40395 (2012)
Anti-cancer therapy based on anthracyclines (DNA intercalating Topoisomerase II inhibitors) is limited by adverse effects of these compounds on the cardiovascular system, ultimately causing heart failure. Despite extensive investigations into the eff
Externí odkaz:
https://doaj.org/article/1bf1e6df5257478dabeac3b061a4a4f0
Autor:
Brian R. Berridge, Szczepan W. Baran, Vivek Kumar, Natalie Bratcher-Petersen, Michael Ellis, Chang-Ning Liu, Timothy L. Robertson
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Though the portfolio of medicines that are extending and improving the lives of patients continues to grow, drug discovery and development remains a challenging business on its best day. Safety liabilities are a significant contributor to development
Externí odkaz:
https://doaj.org/article/ad27030667f84b9e82a29fe81d79692c
Autor:
Yukitomo Arao, Artiom Gruzdev, Gregory J Scott, Manas K Ray, Lauren J Donoghue, Thomas I Neufeld, Sydney L Lierz, Megan L Stefkovich, Emilie Mathura, Tanner Jefferson, Julie F Foley, Beth W Mahler, Arvand Asghari, Courtney Le, Bradley K McConnell, Robert Stephen, Brian R Berridge, Katherine J Hamilton, Sylvia C Hewitt, Michihisa Umetani, Kenneth S Korach
Publikováno v:
J Endocr Soc
Nongenomic effects of estrogen receptor α (ERα) signaling have been described for decades. Several distinct animal models have been generated previously to analyze the nongenomic ERα signaling (eg, membrane-only ER, and ERαC451A). However, the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7ee00f8896a78fd9d0dcd418386945
https://doi.org/10.1210/jendso/bvac109
https://doi.org/10.1210/jendso/bvac109
Autor:
Brian R Berridge
Publikováno v:
ILAR Journal. 62:1-6
Animal research is currently an irreplaceable contributor to our efforts to protect and improve public health. Its relevance, importance, and contributions are represented in historical precedent, regulatory expectations, evidence of our rapidly deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e58eb5117943d38b230c6d28d91f1a7
https://doi.org/10.1093/ilar/ilac005
https://doi.org/10.1093/ilar/ilac005
Publikováno v:
Chemical Research in Toxicology. 34:566-583
Cardiovascular (CV) disease is one of the most prevalent public health concerns, and mounting evidence supports the contribution of environmental chemicals to CV disease burden. In this study, we performed cardiotoxicity profiling for the Tox21 chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0901887347c4e8aa1b7ca43d316359d5
https://doi.org/10.1021/acs.chemrestox.0c00382
https://doi.org/10.1021/acs.chemrestox.0c00382
Autor:
Martyn T. Smith, Brian R. Berridge, Aldrin V. Gomes, Hugo M. Vargas, Kathleen B. Meyer-Tamaki, Xi Yang, Jesus A. Araujo, Changcheng Zhou, Lars Lind, Weihsueh A. Chiu, Sarah Elmore, Nikki Gillum Posnack, Aimen K. Farraj, Cliona M. McHale, Scott M. Belcher, Aaron Barchowsky, Nipavan Chiamvimonvat, Lauren Zeise, Vincent J. Cogliano
Publikováno v:
Environmental health perspectives, vol 129, iss 9
Environmental Health Perspectives
Environmental Health Perspectives
Background: The concept of chemical agents having properties that confer potential hazard called key characteristics (KCs) was first developed to identify carcinogenic hazards. Identification of KCs of cardiovascular (CV) toxicants could facilitate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5a2c80946f4d5acd6e9349926e5619
https://escholarship.org/uc/item/0gh1x5xg
https://escholarship.org/uc/item/0gh1x5xg
Autor:
Xi Yang, Brian R. Berridge, Joseph C. Wu, Frederick Sannajust, Hong Shi, Philip T. Sager, Mathew Brock, Norman Stockbridge, Beverly Lyn-Cook, Najah Abi-Gerges, Li Pang
Publikováno v:
Circulation Research. 125:855-867
Given that cardiovascular safety concerns remain the leading cause of drug attrition at the preclinical drug development stage, the National Center for Toxicological Research of the US Food and Drug Administration hosted a workshop to discuss current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41f220c1310ca8890788ecff775ced03
https://doi.org/10.1161/circresaha.119.315378
https://doi.org/10.1161/circresaha.119.315378
Publikováno v:
Toxicol Pathol
The National Toxicology Program (NTP) uses histopathological evaluation of animal tissues as a key element in its toxicity and carcinogenicity studies. The initial histopathological evaluations are subjected to a rigorous peer review process involvin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014db8d63389ff509d49227ef2f7bab7
https://doi.org/10.1177/0192623319873974
https://doi.org/10.1177/0192623319873974
Autor:
Christine L. Mummery, Lucie A. Low, Brian R. Berridge, Christopher P. Austin, Danilo A. Tagle
Publikováno v:
Nature Reviews Drug Discovery, 20, 345-361. NATURE PUBLISHING GROUP
Nature Reviews Drug Discovery
Nature Reviews Drug Discovery
Organs-on-chips (OoCs), also known as microphysiological systems or ‘tissue chips’ (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81ae9b53e716b7fdcd6cf1ec1851708
https://www.nature.com/articles/s41573-020-0079-3
https://www.nature.com/articles/s41573-020-0079-3
Autor:
Vinicius Carreira, Carie L Kimbrough, Abraham Nyska, Gail Pearse, Noel Dybdal, James R. Hailey, Niraj Tripathi, James D Fikes, Jan Klapwijk, Susan A. Elmore, Ingrid Brees, Beverly E. Maleeff, Kathleen Biddle, Brian R. Berridge, Martin Lamb, Rick Adler, Patrizia Cristofori, Bernard S. Buetow, Jean-Guy Bienvenu, Heather C. Workman, Daniel Morton, Heath C. Thomas, James R. Turk, Jerry F. Hardisty, David A Rehagen, George A. Parker
Publikováno v:
Toxicologic Pathology. 45:1055-1066
To test the diagnostic approach described in part 1 of this article, 2 exercises were completed by pathologists from multiple companies/agencies. Pathologist’s examination of whole slide image (WSI) heart sections from rats using personal diagnosti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811e9dc96e9e43f43e523b82ea909b7d
https://doi.org/10.1177/0192623317743948
https://doi.org/10.1177/0192623317743948