Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Brian Pui Chun Chan"'
Autor:
Jonathan Daniel Ip, Wing-Ming Chu, Wan-Mui Chan, Allen Wing-Ho Chu, Rhoda Cheuk-Ying Leung, Qi Peng, Anthony Raymond Tam, Brian Pui-Chun Chan, Jian-Piao Cai, Kwok-Yung Yuen, Kin-Hang Kok, Yi Shi, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105371- (2024)
Externí odkaz:
https://doaj.org/article/b522914c8c5943c495355d94e058e0b6
Autor:
Jonathan Daniel Ip, Wing-Ming Chu, Wan-Mui Chan, Allen Wing-Ho Chu, Rhoda Cheuk-Ying Leung, Qi Peng, Anthony Raymond Tam, Brian Pui-Chun Chan, Jian-Piao Cai, Kwok-Yung Yuen, Kin-Hang Kok, Yi Shi, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105273- (2024)
Summary: Background: De novo amino acid substitutions (DNS) frequently emerge among immunocompromised patients with chronic SARS-CoV-2 infection. While previous studies have reported these DNS, their significance has not been systematically studied.
Externí odkaz:
https://doaj.org/article/89e94789ce4f4b44920ae257a080861d
Autor:
Hoi-Wah Tsoi, Miko Ka-Wai Ng, Jian-Piao Cai, Rosana Wing-Shan Poon, Brian Pui-Chun Chan, Kwok-Hung Chan, Anthony Raymond Tam, Wing-Ming Chu, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35334- (2024)
The COVID-19 pandemic has had a major impact on global health and economy, which was significantly mitigated by the availability of COVID-19 vaccines. The levels of systemic and mucosal antibodies against SARS-CoV-2 correlated with protection. Howeve
Externí odkaz:
https://doaj.org/article/477b4d7d411c48f8a00cff826dd02256
Autor:
Xiaojuan Zhang, Stephanie Joy-Ann Lam, Jonathan Daniel Ip, Carol Ho-Yan Fong, Allen Wing-Ho Chu, Wan-Mui Chan, Yoyo Suet-Yiu Lai, Hoi-Wah Tsoi, Brian Pui-Chun Chan, Lin-Lei Chen, Xinjie Meng, Shuofeng Yuan, Hanjun Zhao, Vincent Chi-Chung Cheng, Jacqueline Kwan Yuk Yuen, Kwok-Yung Yuen, Jie Zhou, Kelvin Kai-Wang To
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109706- (2024)
Summary: SARS-CoV-2 Omicron variant has evolved into sublineages. Here, we compared the neutralization susceptibility and viral fitness of EG.5.1 and XBB.1.9.1. Serum neutralization antibody titer against EG.5.1 was 1.71-fold lower than that for XBB.
Externí odkaz:
https://doaj.org/article/408891a80f1f40e78aaa030c09782216
Autor:
Desmond Yat-Hin Yap, Carol Ho-Yan Fong, Xiaojuan Zhang, Jonathan Daniel Ip, Wan-Mui Chan, Allen Wing-Ho Chu, Lin-Lei Chen, Yan Zhao, Brian Pui-Chun Chan, Kristine Shik Luk, Vincent Chi-Chung Cheng, Tak-Mao Chan, Kelvin Kai-Wang To
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Chronic kidney disease (CKD) patients are at higher risk of severe COVID-19. Humoral and cellular immunity from prior infection or vaccination are important for protection, but the neutralizing antibody (nAb) response against SARS-CoV-2 vari
Externí odkaz:
https://doaj.org/article/65a4fc7343c04329a778daf9e06c2afe
Autor:
Lin-Lei Chen, Gilbert T. Chua, Lu Lu, Brian Pui-Chun Chan, Joshua Sung-Chih Wong, Calvin Chit-Kwong Chow, Tak-Ching Yu, Agnes Sze-Yin Leung, Shu-Yan Lam, Tak-Wai Wong, Hing-Wai Tsang, Ian Chi-Kei Wong, Kwok-Hung Chan, Kwok-Yung Yuen, Patrick Ip, Mike Yat-Wah Kwan, Kelvin Kai-Wang To
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 543-547 (2022)
The novel SARS-CoV-2 Omicron variant may increase the risk of re-infection and vaccine breakthrough infections as it possesses key mutations in the spike protein that affect neutralizing antibody response. Most studies on neutralization susceptibilit
Externí odkaz:
https://doaj.org/article/fa42fb5f36ec4469a863f714520048f0
Autor:
Rosana Wing-Shan Poon, Brian Pui-Chun Chan, Wan-Mui Chan, Carol Ho-Yan Fong, Xiaojuan Zhang, Lu Lu, Lin-Lei Chen, Joy-Yan Lam, Vincent Chi-Chung Cheng, Samson S. Y. Wong, Kin-Hang Kok, Kwok-Yung Yuen, Kelvin Kai-Wang To
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 2116-2119 (2022)
The SARS-CoV-2 Omicron variant has led to a major wave of COVID-19 in Hong Kong between January and May 2022. Here, we used seroprevalence to estimate the combined incidence of vaccination and SARS-CoV-2 infection, including subclinical infection whi
Externí odkaz:
https://doaj.org/article/90316ecf3ca34664b3cafee5984b2e85
Autor:
Lin-Lei Chen, Syed Muhammad Umer Abdullah, Wan-Mui Chan, Brian Pui-Chun Chan, Jonathan Daniel Ip, Allen Wing-Ho Chu, Lu Lu, Xiaojuan Zhang, Yan Zhao, Vivien Wai-Man Chuang, Albert Ka-Wing Au, Vincent Chi-Chung Cheng, Siddharth Sridhar, Kwok-Yung Yuen, Ivan Fan-Ngai Hung, Kwok-Hung Chan, Kelvin Kai-Wang To
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Hong Kong experienced a severe wave of SARS-CoV-2 in early 2022. Here, the authors use genomic and serosurveillance data and show that this wave was dominated by the Omicron BA.2 sublineage, and that low protective immunity, particularly in older age
Externí odkaz:
https://doaj.org/article/d3d5deb077c94ee4a04f0fadaf2f765e
Autor:
Carol Ho-Yan Fong, Xiaojuan Zhang, Lin-Lei Chen, Rosana Wing-Shan Poon, Brian Pui-Chun Chan, Yan Zhao, Carlos King-Ho Wong, Kwok-Hung Chan, Kwok-Yung Yuen, Ivan Fan-Ngai Hung, Jacqueline Kwan Yuk Yuen, Kelvin Kai-Wang To
Publikováno v:
EBioMedicine, Vol 88, Iss , Pp 104446- (2023)
Summary: Background: Vaccination reduces COVID-19-related hospitalization among older adults. However, how SARS-CoV-2 infection and vaccine regimens affect vaccine-elicited immunity remain unclear. Methods: This is a cross-sectional study recruiting
Externí odkaz:
https://doaj.org/article/414c3d0b747343d7b603d4c162a825c5
Autor:
Lu Lu, Lin-Lei Chen, Ricky Rui-Qi Zhang, Owen Tak-Yin Tsang, Jacky Man-Chun Chan, Anthony Raymond Tam, Wai-Shing Leung, Thomas Shiu-Hong Chik, Daphne Pui-Ling Lau, Chris Yau-Chung Choi, Carol Ho-Yan Fong, Jian-Piao Cai, Hoi-Wah Tsoi, Charlotte Yee-Ki Choi, Xiaojuan Zhang, Syed Muhammad Umer Abdullah, Brian Pui-Chun Chan, Kwok-Hung Chan, Kwok-Yung Yuen, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To
Publikováno v:
EBioMedicine, Vol 79, Iss , Pp 103986- (2022)
Summary: Background: SARS-CoV-2 Omicron variant evades immunity from past infection or vaccination and is associated with a greater risk of reinfection among recovered COVID-19 patients. We assessed the serum neutralizing antibody (NAb) activity agai
Externí odkaz:
https://doaj.org/article/935d5dba23fb4d098825c753ef442269