Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Brian PH Metzger"'
Publikováno v:
eLife, Vol 12 (2024)
A protein’s genetic architecture – the set of causal rules by which its sequence produces its functions – also determines its possible evolutionary trajectories. Prior research has proposed that the genetic architecture of proteins is very comp
Externí odkaz:
https://doaj.org/article/322993c1c1ed478d814735598c95cd5f
Autor:
Fabien Duveau, Petra Vande Zande, Brian PH Metzger, Crisandra J Diaz, Elizabeth A Walker, Stephen Tryban, Mohammad A Siddiq, Bing Yang, Patricia J Wittkopp
Publikováno v:
eLife, Vol 10 (2021)
Heritable variation in a gene’s expression arises from mutations impacting cis- and trans-acting components of its regulatory network. Here, we investigate how trans-regulatory mutations are distributed within the genome and within a gene regulator
Externí odkaz:
https://doaj.org/article/9117cc5c21474ed4a6d1e59f75783250
Publikováno v:
eLife, Vol 10 (2021)
The roles of chance, contingency, and necessity in evolution are unresolved because they have never been assessed in a single system or on timescales relevant to historical evolution. We combined ancestral protein reconstruction and a new continuous
Externí odkaz:
https://doaj.org/article/cbd4a960942f48688a4bc4cbdf8ec653
Autor:
Fabien Duveau, Andrea Hodgins-Davis, Brian PH Metzger, Bing Yang, Stephen Tryban, Elizabeth A Walker, Tricia Lybrook, Patricia J Wittkopp
Publikováno v:
eLife, Vol 7 (2018)
Gene expression noise is an evolvable property of biological systems that describes differences in expression among genetically identical cells in the same environment. Prior work has shown that expression noise is heritable and can be shaped by sele
Externí odkaz:
https://doaj.org/article/1dcbb6017cd34355858dd28fe6b52266
Autor:
Fabien, Duveau, Petra, Vande Zande, Brian Ph, Metzger, Crisandra J, Diaz, Elizabeth A, Walker, Stephen, Tryban, Mohammad A, Siddiq, Bing, Yang, Patricia J, Wittkopp
Publikováno v:
eLife
Heritable variation in a gene’s expression arises from mutations impacting cis- and trans-acting components of its regulatory network. Here, we investigate how trans-regulatory mutations are distributed within the genome and within a gene regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c0f7896e35a9e2f4671515807402f68
https://pubmed.ncbi.nlm.nih.gov/34463616
https://pubmed.ncbi.nlm.nih.gov/34463616