Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Brian P. Schmidt"'
Autor:
Brennen O’Dell, Gary Rothenberg, Crystal Holmes, Sari Priesand, Kara Mizokami-Stout, Eric J. Brandt, Brian M. Schmidt
Publikováno v:
Clinical Diabetes and Endocrinology, Vol 10, Iss 1, Pp 1-6 (2024)
Abstract Background Diabetic foot ulcers (DFU) are a costly complication of diabetes mellitus (DM), with significant implications for the patient and the healthcare professionals that treat them. The primary objective of this study was to evaluate if
Externí odkaz:
https://doaj.org/article/35bf480270d3451392cb9be78749c03b
Autor:
Armani M Hawes, Rodica Pop-Busui, Brian M Schmidt, Toby P Keeney-Bonthrone, Monika Karmakar, Lynn M Frydrych, Sandro K Cinti, Matthew J Delano
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 11, Iss 6 (2023)
Introduction Osteomyelitis is associated with significant morbidity, including amputation. There are limited data on long-term amputation rates following an osteomyelitis diagnosis. We sought to determine the incidence of amputation in patients with
Externí odkaz:
https://doaj.org/article/73affd44d2844e1ab993eeeb5925ada2
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 12, Pp 1547-1551 (2022)
Abstract The phase distribution model, proposed by Atkinson and Begg in 1990, has been widely used for predicting breastmilk‐to‐plasma drug concentration ratio. However, misrepresentations of the equations have been noted in recent publications.
Externí odkaz:
https://doaj.org/article/2070a3d5d02c48fbb2fb7f2bfdbc196d
Autor:
Caroline M. Sawicki, Malvin N. Janal, Samuel J. Nicholson, Angie K. Wu, Brian L. Schmidt, Donna G. Albertson
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Introduction Oral cancer patients suffer severe chronic and mechanically-induced pain at the site of the cancer. Our clinical experience is that oral cancer patients report new sensitivity to spicy foods. We hypothesized that in cancer patie
Externí odkaz:
https://doaj.org/article/b3cce90b24b7405881dd244c24e99b9f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16224 (2023)
A permeability-limited physiologically based pharmacokinetic (PBPK) model featuring four subcompartments (corresponding to the intracellular and extracellular water of the tissue, the residual plasma, and blood cells) for each tissue has been develop
Externí odkaz:
https://doaj.org/article/de8213100d24426d8ee7e191cae0ce3e
Publikováno v:
Water, Vol 15, Iss 22, p 3937 (2023)
Powerplants frequently use river water for cooling, subsequently discharging warm effluent. Some of these plants can cycle on and off rapidly based on electricity demand, resulting in dramatic temperature fluctuations in the receiving waters. To unde
Externí odkaz:
https://doaj.org/article/2522efb9d3b142d592bb363f5ff52ffc
Autor:
Brian M. Schmidt, Laura Shin
Publikováno v:
Therapeutic Advances in Endocrinology and Metabolism, Vol 14 (2023)
Purpose: Lower extremity amputation resulting from diabetic foot ulcer, with neuropathic and/or ischemic etiologies, remains a devastating and costly complication of diabetes mellitus. This study evaluated changes in care delivery of diabetic foot ul
Externí odkaz:
https://doaj.org/article/c913384336a54d0198ab0dbd0af97ed7
Autor:
Nicole N. Scheff, Ian M. Wall, Sam Nicholson, Hannah Williams, Elyssa Chen, Nguyen H. Tu, John C. Dolan, Cheng Z. Liu, Malvin N. Janal, Nigel W. Bunnett, Brian L. Schmidt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Oral cancer patients report sensitivity to spicy foods and liquids. The mechanism responsible for chemosensitivity induced by oral cancer is not known. We simulate oral cancer-induced chemosensitivity in a xenograft oral cancer mouse model u
Externí odkaz:
https://doaj.org/article/18f2ffcae6f84a02abb412b9786e83d1
Autor:
Francesco De Logu, Romina Nassini, Alan Hegron, Lorenzo Landini, Dane D. Jensen, Rocco Latorre, Julia Ding, Matilde Marini, Daniel Souza Monteiro de Araujo, Paulina Ramírez-Garcia, Michael Whittaker, Jeffri Retamal, Mustafa Titiz, Alessandro Innocenti, Thomas P. Davis, Nicholas Veldhuis, Brian L. Schmidt, Nigel W. Bunnett, Pierangelo Geppetti
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The mechanism of CGRP-evoked peripheral pain is unclear. Here, the authors show that the CGRP-mediated neuronal/Schwann cell pathway mediates allodynia associated with neurogenic inflammation, contributing to the algesic action of CGRP in mice.
Externí odkaz:
https://doaj.org/article/279bcfd8279341c7ae1422cec3fc2183
Autor:
Nguyen Huu Tu, Kenji Inoue, Parker K. Lewis, Ammar Khan, Jun Hyeong Hwang, Varun Chokshi, Branka Brukner Dabovic, Shanmugapriya Selvaraj, Aditi Bhattacharya, Zinaida Dubeykovskaya, Nathalie M. Pinkerton, Nigel W. Bunnett, Cynthia A. Loomis, Donna G. Albertson, Brian L. Schmidt
Publikováno v:
Cells, Vol 12, Iss 13, p 1675 (2023)
Oral cancer patients suffer pain at the site of the cancer. Calcitonin gene related polypeptide (CGRP), a neuropeptide expressed by a subset of primary afferent neurons, promotes oral cancer growth. CGRP also mediates trigeminal pain (migraine) and n
Externí odkaz:
https://doaj.org/article/4ad97754b9c84ef08dfb3e97512427c3