Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Brian P. Lam"'
1
Akademický článek
The changing landscape of hepatitis C virus therapy: focus on interferon-free treatment
Autor: Brian P. Lam, Thomas Jeffers, Zahra Younoszai, Yousef Fazel, Zobair M. Younossi
Publikováno v: Therapeutic Advances in Gastroenterology, Vol 8 (2015)
Chronic hepatitis C (CHC) affects over 185 million individuals worldwide, approximately 3% of the world’s population. CHC can lead to quality of life impairment, cirrhosis, hepatocellular carcinoma (HCC), liver failure and liver-related death. Whil
Externí odkaz: https://doaj.org/article/b9ba5861e6694236b962868dc380ef1f
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3
Akademický článek
Treatment regimens for non-alcoholic fatty liver disease
Autor: Brian P. Lam, Zobair M. Younossi
Publikováno v: Annals of Hepatology, Vol 8, Iss , Pp S51-S59 (2009)
With the growing epidemic of obesity and diabetes, more attention has been placed on metabolic syndrome and its associated hepatic manifestation, non-alcoholic fatty liver disease (NAFLD). Within the spectrum of clinico-pathologic conditions known as
Externí odkaz: https://doaj.org/article/513c23bba2344f94919a72c40d22ce53
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4
Akademický článek
The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake
Autor: Aldara Martin Alonso, Simon C. Cork, Phyllis Phuah, Benjamin Hansen, Mariana Norton, Sijing Cheng, Xiang Xu, Kinga Suba, Yue Ma, Georgina KC. Dowsett, John A. Tadross, Brian YH. Lam, Giles SH. Yeo, Herbert Herzog, Stephen R. Bloom, Myrtha Arnold, Walter Distaso, Kevin G. Murphy, Victoria Salem
Publikováno v: Molecular Metabolism, Vol 81, Iss , Pp 101895- (2024)
Peptide YY (PYY3-36) is a post-prandially released gut hormone with potent appetite-reducing activity, the mechanism of action of which is not fully understood. Unravelling how this system physiologically regulates food intake may help unlock its the
Externí odkaz: https://doaj.org/article/8ca434c5412d4079a5b6bb6f4eff13e9
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5
Akademický článek
A program of successive gene expression in mouse one-cell embryos
Autor: Maki Asami, Brian Y.H. Lam, Martin Hoffmann, Toru Suzuki, Xin Lu, Naoko Yoshida, Marcella K. Ma, Kara Rainbow, Miodrag Gužvić, Matthew D. VerMilyea, Giles S.H. Yeo, Christoph A. Klein, Anthony C.F. Perry
Publikováno v: Cell Reports, Vol 42, Iss 2, Pp 112023- (2023)
Summary: At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for development, yet its timing and profile remain elusive i
Externí odkaz: https://doaj.org/article/58b7a14aaceb4f2b84375d76e14ddecf
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6
Akademický článek
Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression
Autor: Stefan Wagner, Daniel I. Brierley, Alasdair Leeson-Payne, Wanqing Jiang, Raffaella Chianese, Brian Y.H. Lam, Georgina K.C. Dowsett, Claudia Cristiano, David Lyons, Frank Reimann, Fiona M. Gribble, Pablo B. Martinez de Morentin, Giles S.H. Yeo, Stefan Trapp, Lora K. Heisler
Publikováno v: Molecular Metabolism, Vol 68, Iss , Pp 101665- (2023)
Objective: Overweight and obesity are endemic in developed countries, with a substantial negative impact on human health. Medications developed to treat obesity include agonists for the G-protein coupled receptors glucagon-like peptide-1 (GLP-1R; e.g
Externí odkaz: https://doaj.org/article/a7f4d6b4357e4a4d9af68e183e845a6f
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7
Post-Acute SARS-CoV-2 Symptoms are Fewer, Less Intense Over Time in People Treated with Mono-Clonal Antibodies for Acute Infection
Autor: Jillian Kallman Price, Lynn H Gerber, Maria Stepanova, Leyla de Avila, Ali A Weinstein, Huong Pham, Fatema Nader, Mariam Afendy, Kathy Terra, Patrick Austin, Wisna’odom Keo, Andrei Racila, James Michael Estep, Suzannah Gerber, Manisha Verma, Pegah Golabi, Brian P Lam, Zobair Younossi
Publikováno v: International Journal of General Medicine. 16:1479-1490
Jillian Kallman Price,1 Lynn H Gerber,1,2 Maria Stepanova,1– 3 Leyla de Avila,1 Ali A Weinstein,4 Huong Pham,1 Fatema Nader,1 Mariam Afendy,1 Kathy Terra,3 Patrick Austin,1 Wisna’odom Keo,1 Andrei Racila,1 James Michael Estep,1 Suzannah Ger
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12c4491cfbec9e5d517e76fea682a60
https://doi.org/10.2147/ijgm.s406571
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10
Akademický článek
Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice
Autor: Jorge López-Tello, Vicente Pérez-García, Jaspreet Khaira, Laura C Kusinski, Wendy N Cooper, Adam Andreani, Imogen Grant, Edurne Fernández de Liger, Brian YH Lam, Myriam Hemberger, Ionel Sandovici, Miguel Constancia, Amanda N Sferruzzi-Perri
Publikováno v: eLife, Vol 8 (2019)
Studies suggest that placental nutrient supply adapts according to fetal demands. However, signaling events underlying placental adaptations remain unknown. Here we demonstrate that phosphoinositide 3-kinase p110α in the fetus and the trophoblast in
Externí odkaz: https://doaj.org/article/57db7a58e0f24f85a79ce8d6453f5b04
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