Výsledky vyhledávání - "Brian P. Kenealy"

Obligatory role of hypothalamic neuroestradiol during the estrogen-induced LH surge in female ovariectomized rhesus monkeys

Autor: James P. Garcia, Lucille Kohlenberg, Brian P. Kenealy, Ei Terasawa, Kim L. Keen

Publikováno v: Proceedings of the National Academy of Sciences. 114:13804-13809

Negative and positive feedback effects of ovarian 17β-estradiol (E2) regulating release of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) are pivotal events in female reproductive function. While ovarian feedback on hypothalamo�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0fd16b41e69537d3df111746734cd5
https://doi.org/10.1073/pnas.1716097115

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Role of Kisspeptin and Neurokinin B Signaling in Male Rhesus Monkey Puberty

Autor: James P. Garcia, Stephanie B. Seminara, Ei Terasawa, Brian P. Kenealy, Kim L. Keen

Publikováno v: Endocrinology. 159(8)

Despite the well-established concept that an increase in pulsatile GnRH release triggers puberty, the precise signaling mechanism responsible for the pubertal increase in GnRH release remains unclear. A recent study indicates that developmental chang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d03da07132ba5fe83bfd624444d65b
https://pubmed.ncbi.nlm.nih.gov/29982393

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Neuroestradiol in the Stalk Median Eminence of Female Rhesus Macaques Decreases in Association With Puberty Onset

Autor: Amita Kapoor, Brian P. Kenealy, Ei Terasawa, Kim L. Keen

Publikováno v: Endocrinology. 157:70-76

In primates, despite the fact that GnRH neurons are mature at birth, a gonadal steroid independent central inhibition restrains the initiation of puberty. The neural substrates responsible for this central inhibition, however, are unclear. In this st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8800372c442060e4fb39b25c381aedbc
https://doi.org/10.1210/en.2015-1770

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Acute Influences of Bisphenol A Exposure on Hypothalamic Release of Gonadotropin-Releasing Hormone and Kisspeptin in Female Rhesus Monkeys

Autor: Ei Terasawa, James P. Garcia, Joseph R. Kurian, Curtis J. Hedman, Brian P. Kenealy, Kim L. Keen

Publikováno v: Endocrinology. 156:2563-2570

Bisphenol A (BPA) is an industrial compound with pervasive distribution in the environments of industrialized countries. The U.S. Centers for Disease Control recently found that greater than 90% of Americans carry detectable levels of BPA, raising co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4b5e21eb60b72f21f78bcccddc16d6
https://doi.org/10.1210/en.2014-1634

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Kisspeptin and Neurokinin B Signaling Network Underlies the Pubertal Increase in GnRH Release in Female Rhesus Monkeys

Autor: Ei Terasawa, Brian P. Kenealy, Stephanie B. Seminara, Kim L. Keen, James P. Garcia, Kathryn A. Guerriero

Loss-of-function or inactivating mutations in the genes coding for kisspeptin and its receptor (KISS1R) or neurokinin B (NKB) and the NKB receptor (NK3R) in humans result in a delay in or the absence of puberty. However, precise mechanisms of kisspep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6654db302e2d0e0d5b2bff80db8295e8
https://europepmc.org/articles/PMC5659687/

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Hypothalamic Control of Female Reproduction

Autor: Brian P. Kenealy, Ei Terasawa

Female reproduction is an interplay between the hypothalamus, pituitary, and ovaries. While the gonadotropin releasing hormone (GnRH) neuron in the hypothalamus regulates gonadal function through the pituitary, GnRH neuronal activity is also profound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfc926145081767cba3c4ee816e39843
https://doi.org/10.1093/acrefore/9780190264086.013.59

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Neuroestrogen, rapid action of estradiol, and GnRH neurons

Autor: Brian P. Kenealy, Ei Terasawa

Publikováno v: Frontiers in Neuroendocrinology. 33:364-375

Estradiol plays a pivotal role in the control of GnRH neuronal function, hence female reproduction. A series of recent studies in our laboratory indicate that rapid excitatory actions of estradiol directly modify GnRH neuronal activity in primate GnR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8e6f59bdcc863fcec474041eefd49d
https://doi.org/10.1016/j.yfrne.2012.08.001

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Prolonged infusion of estradiol benzoate into the stalk median eminence stimulates release of GnRH and kisspeptin in ovariectomized female rhesus macaques

Autor: Brian P. Kenealy, Kim L. Keen, Dustin J. Richter, James P. Garcia, Ei Terasawa

Publikováno v: Endocrinology. 156(5)

Our recent study indicates that a brief infusion (20 min) of estradiol (E2) benzoate (EB) into the stalk-median eminence (S-ME) stimulates GnRH release with a latency of approximately 10 minutes. In contrast to the effect induced by a brief infusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9561311c0a890a3b9dad5873de8620b6
https://pubmed.ncbi.nlm.nih.gov/25734362

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Rapid Direct Action of Estradiol in GnRH Neurons: Findings and Implications

Autor: Brian P. Kenealy, Ei Terasawa

Publikováno v: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 2 (2012)

Estradiol plays a pivotal role in the control of gonadotropin-releasing hormone (GnRH) neuronal function and female reproduction. While positive and negative feedback actions of estradiol that enhance and suppress release of GnRH and LH are primarily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb76d663c8dbf701c3d64620a04d367

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