Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Brian P. H. Metzger"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract How complex are the rules by which a protein’s sequence determines its function? High-order epistatic interactions among residues are thought to be pervasive, suggesting an idiosyncratic and unpredictable sequence-function relationship. Bu
Externí odkaz:
https://doaj.org/article/964a2df1f4ba4080b5de69b6542ea0a9
Publikováno v:
Evolution Letters, Vol 3, Iss 5, Pp 448-461 (2019)
Abstract Heritable variation in gene expression is common within species. Much of this variation is due to genetic differences outside of the gene with altered expression and is trans‐acting. This trans‐regulatory variation is often polygenic, wi
Externí odkaz:
https://doaj.org/article/e5e0737f12df455888cb33edfd2b15b4
Autor:
Crisandra J Diaz, Mohammad A Siddiq, Brian P. H. Metzger, Stephen Tryban, Bing Yang, Elizabeth A. Walker, Patricia J. Wittkopp, Fabien Duveau, Petra Vande Zande
Publikováno v:
eLife
eLife, 2021, 10, ⟨10.7554/eLife.67806⟩
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.67806⟩
eLife, Vol 10 (2021)
eLife, 2021, 10, ⟨10.7554/eLife.67806⟩
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.67806⟩
eLife, Vol 10 (2021)
Heritable variation in a gene’s expression arises from mutations impacting cis- and trans-acting components of its regulatory network. Here, we investigate how trans-regulatory mutations are distributed within the genome and within a gene regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02c0bbca6059a2f93418cd68814c28f
https://hal.science/hal-03440690
https://hal.science/hal-03440690
Autor:
Petra Vande Zande, Mohammad A Siddiq, Elizabeth A. Walker, Crisandra J Diaz, Fabien Duveau, Bing Yang, Brian P. H. Metzger, Patricia J. Wittkopp, Stephen Tryban
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633f5e2a73c56851185828a5f361757c
https://doi.org/10.7554/elife.67806.sa2
https://doi.org/10.7554/elife.67806.sa2
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The roles of chance, contingency, and necessity in evolution are unresolved because they have never been assessed in a single system or on timescales relevant to historical evolution. We combined ancestral protein reconstruction and a new continuous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0068a882bc66af58b797264913cfc8
https://elifesciences.org/articles/67336
https://elifesciences.org/articles/67336
Publikováno v:
Evolution Letters, Vol 3, Iss 5, Pp 448-461 (2019)
Evolution Letters
Evolution Letters
Heritable variation in gene expression is common within species. Much of this variation is due to genetic differences outside of the gene with altered expression and is trans-acting. This trans-regulatory variation is often polygenic, with individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e00e04accfc503a2c96436cb3315c65
https://doaj.org/article/e5e0737f12df455888cb33edfd2b15b4
https://doaj.org/article/e5e0737f12df455888cb33edfd2b15b4
Mutational sources oftrans-regulatory variation affecting gene expression inSaccharomyces cerevisiae
Autor:
Patricia J. Wittkopp, Stephen Tryban, Crisandra J Diaz, Brian P. H. Metzger, Petra Vande Zande, Elizabeth A. Walker, Mohammad A Siddiq, Fabien Duveau, Bing Yang
Heritable variation in a gene’s expression arises from mutations impactingcis- andtrans-acting components of its regulatory network, with expression variation often derived fromtrans-regulatory mutations within species. Here, we investigate howtran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e93c1fe282ccb3dc90c14354a1f6f1
https://doi.org/10.1101/2021.02.22.432283
https://doi.org/10.1101/2021.02.22.432283
Autor:
Joseph W. Thornton, Erik G. Marklund, Brian P. H. Metzger, Georg K. A. Hochberg, Yang Liu, Arthur Laganowsky
Publikováno v:
Nature
Most proteins assemble into multisubunit complexes1. The persistence of these complexes across evolutionary time is usually explained as the result of natural selection for functional properties that depend on multimerization, such as intersubunit al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555499d1a7a932d7ff98fbbf0bf305d2
https://hdl.handle.net/21.11116/0000-000A-76A3-9
https://hdl.handle.net/21.11116/0000-000A-76A3-9
Autor:
Wei-Chin Ho, Bryan A. Moyers, Jianzhi Zhang, Calum J. Maclean, Brian P. H. Metzger, Jian-Rong Yang
Publikováno v:
Molecular Biology and Evolution. 34:2486-2502
The budding yeast Saccharomyces cerevisiae is the best studied eukaryote in molecular and cell biology, but its utility for understanding the genetic basis of phenotypic variation in natural populations is limited by inefficient association mapping d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de0e7af29dc739d19584c03b939ce00
https://doi.org/10.1093/molbev/msx151
https://doi.org/10.1093/molbev/msx151