Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Brian P. Cox"'
Autor:
Sarah C. Simmons, William J. Flerlage, Ludovic D. Langlois, Ryan D. Shepard, Christopher Bouslog, Emily H. Thomas, Kaitlyn M. Gouty, Jennifer L. Sanderson, Shawn Gouty, Brian M. Cox, Mark L. Dell’Acqua, Fereshteh S. Nugent
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability. Emerging evidence also suggests that AKAP150 signaling may p
Externí odkaz:
https://doaj.org/article/d0756070792248e3952cc58c533d07ad
Autor:
Natalie D Mercuri, Brian J Cox
Publikováno v:
eLife, Vol 11 (2022)
Reproductive diseases have a significant impact on human health, especially on women’s health: endometriosis affects 10% of all reproductive-aged women but is often undiagnosed for many years, and preeclampsia claims over 70,000 maternal and 500,00
Externí odkaz:
https://doaj.org/article/a16dc4973cf34ecebf1f7a9ffbefe951
Autor:
Andrew D. Biancolin, Alexandre Martchenko, Emilia Mitova, Patrick Gurges, Everan Michalchyshyn, Jennifer A. Chalmers, Alessandro Doria, Josyf C. Mychaleckyj, Alice E. Adriaenssens, Frank Reimann, Fiona M. Gribble, Manuel Gil-Lozano, Brian J. Cox, Patricia L. Brubaker
Publikováno v:
Molecular Metabolism, Vol 31, Iss , Pp 124-137 (2020)
Objectives: The incretin hormone glucagon-like peptide-1 (GLP-1) is secreted from intestinal L-cells upon nutrient intake. While recent evidence has shown that GLP-1 is released in a circadian manner in rats, whether this occurs in mice and if this p
Externí odkaz:
https://doaj.org/article/f6ff2737afcd47bc877a504901b598cc
Autor:
Sarah C. Simmons, Ryan D. Shepard, Shawn Gouty, Ludovic D. Langlois, William J. Flerlage, Brian M. Cox, Fereshteh S. Nugent
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100267- (2020)
The lateral habenula (LHb) is an epithalamic brain region associated with value-based decision making and stress evasion through its modulation of dopamine (DA)-mediated reward circuitry. Specifically, increased activity of the LHb is associated with
Externí odkaz:
https://doaj.org/article/88499a55428542f7ac83e5501b9e346f
Autor:
Saifur R. Khan, Yousef Manialawy, Andreea Obersterescu, Brian J. Cox, Erica P. Gunderson, Michael B. Wheeler
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101566- (2020)
Summary: Gestational diabetes mellitus (GDM) is the top risk factor for future type 2 diabetes (T2D) development. Ethnicity profoundly influences who will transition from GDM to T2D, with high risk observed in Hispanic women. To better understand thi
Externí odkaz:
https://doaj.org/article/cdc471ed33b94c3c9c907f1a2bdd7258
Autor:
Mi Lai, Ying Liu, Gabriele V Ronnett, Anne Wu, Brian J Cox, Feihan F Dai, Hannes L Röst, Erica P Gunderson, Michael B Wheeler
Publikováno v:
PLoS Medicine, Vol 17, Iss 5, p e1003112 (2020)
BACKGROUND:Women with a history of gestational diabetes mellitus (GDM) have a 7-fold higher risk of developing type 2 diabetes (T2D) during midlife and an elevated risk of developing hypertension and cardiovascular disease. Glucose tolerance reclassi
Externí odkaz:
https://doaj.org/article/7e9636479dfc4a6a918ea8161fc6903d
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background Preeclampsia (PE) is a heterogeneous, hypertensive disorder of pregnancy, with no robust biomarkers or effective treatments. We hypothesized that this heterogeneity is due to the existence of multiple subtypes of PE and, in suppor
Externí odkaz:
https://doaj.org/article/c19cb96105de49559dce243986ab5a0f
Autor:
Rohan R. Nadkarni, Soumeya Abed, Brian J. Cox, Sonam Bhatia, Jennifer T. Lau, Michael G. Surette, Jonathan S. Draper
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 897-912 (2017)
Intestinal organoids derived from human pluripotent stem cells (hPSCs) are valuable in vitro research models that enable simplified access to human gastrointestinal tissues. Here, we report the in vitro generation of enterospheres (hEnS) from hPSC-de
Externí odkaz:
https://doaj.org/article/41d69864262a46b59e95fb751b24aedd
Autor:
Francis Hassard, Anthony Andrews, Davey L. Jones, Louise Parsons, Vera Jones, Brian A. Cox, Peter Daldorph, Howard Brett, James E. McDonald, Shelagh K. Malham
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
To assess fecal pollution in coastal waters, current monitoring is reliant on culture-based enumeration of bacterial indicators, which does not account for the presence of viable but non-culturable or sediment-associated micro-organisms, preventing e
Externí odkaz:
https://doaj.org/article/397d6d6d7c3c4bf68adce71f24f0cf36
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 1, Pp 113-124 (2011)
15-Deoxy-Δ12,14-prostaglandin J2 (15-d-PGJ2) is a reactive cyclopentenone eicosanoid generated from the dehydration of cyclooxygenase-derived prostaglandin D2 (PGD2). This compound possesses an α,β-unsaturated carbonyl moiety that can readily addu
Externí odkaz:
https://doaj.org/article/7b82ac2cd0164f22a4752b850669f4ad