Zobrazeno 1 - 10
of 395
pro vyhledávání: '"Brian P Rubin"'
Autor:
Kepeng Che, Ajaybabu V Pobbati, Caleb N Seavey, Yuriy Fedorov, Anton A Komar, Ashley Burtscher, Shuang Ma, Brian P Rubin
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266143 (2022)
Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we repor
Externí odkaz:
https://doaj.org/article/8a4ef1a458ba481fb6afe6bc523ac235
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0252689 (2021)
Activating mutations in KIT/PDGFRA receptor tyrosine kinases drive gastrointestinal stromal tumors (GIST). KIT/PDGFRA inhibitors, such as imatinib do not evoke an effective cytocidal response, leaving room for quiescence and development of multiple s
Externí odkaz:
https://doaj.org/article/3f675bfa772e48718fdca10309f3961d
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Healthcare data accessibility for machine learning (ML) is encumbered by a range of stringent regulations and limitations. Using synthetic data that mirrors the underlying properties in the real data is emerging as a promising solution to ov
Externí odkaz:
https://doaj.org/article/7a7170b5349d45c3bf1961f2bfa1db3b
Autor:
Ken Kikuchi, Simone Hettmer, M Imran Aslam, Joel E Michalek, Wolfram Laub, Breelyn A Wilky, David M Loeb, Brian P Rubin, Amy J Wagers, Charles Keller
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004107 (2014)
Rhabdomyosarcoma is the most commonly occurring soft-tissue sarcoma in childhood. Most rhabdomyosarcoma falls into one of two biologically distinct subgroups represented by alveolar or embryonal histology. The alveolar subtype harbors a translocation
Externí odkaz:
https://doaj.org/article/2b962197f389464cb0077162d3db4ee4
Autor:
Yujiro Hayashi, David T Asuzu, Simon J Gibbons, Kirsten H Aarsvold, Michael R Bardsley, Gwen A Lomberk, Angela J Mathison, Michael L Kendrick, K Robert Shen, Takahiro Taguchi, Anu Gupta, Brian P Rubin, Jonathan A Fletcher, Gianrico Farrugia, Raul A Urrutia, Tamas Ordog
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76822 (2013)
Stem cell factor (mouse: Kitl, human: KITLG) and insulin-like growth factor-1 (IGF1), acting via KIT and IGF1 receptor (IGF1R), respectively, are critical for the development and integrity of several tissues. Autocrine/paracrine KITLG-KIT and IGF1-IG
Externí odkaz:
https://doaj.org/article/6a36f60b865849fca0e540962e4685c9
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14710 (2011)
Gastrointestinal stromal tumors (GIST) are thought to derive from the interstitial cells of Cajal (ICC) or an ICC precursor. Oncogenic mutations of the KIT or PDGFRA receptor tyrosine kinases are present in the majority of GIST, leading to ligand-ind
Externí odkaz:
https://doaj.org/article/64457b42dfda45f9b0a68a89174d56d0
Autor:
Robert B West, Dimitry S A Nuyten, Subbaya Subramanian, Torsten O Nielsen, Christopher L Corless, Brian P Rubin, Kelli Montgomery, Shirley Zhu, Rajiv Patel, Tina Hernandez-Boussard, John R Goldblum, Patrick O Brown, Marc van de Vijver, Matt van de Rijn
Publikováno v:
PLoS Biology, Vol 3, Iss 6, p e187 (2005)
Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells or different activation states of these cells. We
Externí odkaz:
https://doaj.org/article/de934ec3dc864753843b37b14afad90a
Autor:
Shinsuke Nomura, Shinya Yokomizo, Zhidong Wang, Homan Kang, Kai Bao, Chengeng Yang, Brian P. Rubin, Roderick Bronson, Satoshi Kashiwagi, Hak Soo Choi
Publikováno v:
Advanced NanoBiomed Research, Vol 3, Iss 12, Pp n/a-n/a (2023)
Complete resection without damaging the capsule is the gold‐standard surgical approach for nonmetastatic gastrointestinal stromal tumors (GIST). However, accurately locating tumors during surgery is challenging because GIST is covered by normal muc
Externí odkaz:
https://doaj.org/article/c6e5ebad2cc14e4c8944ce7878443e3c
Autor:
Joshua M. Lawrenz, Samuel R. Johnson, Kevin Zhu, Mallory McKeon, Cullen P. Moran, Jose Vega, Katherine S. Hajdu, James P. Norris, Leo Y. Luo, Eric T. Shinohara, Justin M. M. Cates, Brian P. Rubin, John D. Reith, Jennifer L. Halpern, Nathan W. Mesko, Herbert S. Schwartz, Lukas M. Nystrom, Ginger E. Holt
Publikováno v:
Sarcoma, Vol 2022 (2022)
Background. Radiation after resection of an atypical lipomatous tumor (ALT) is controversial. This study evaluates local control and complications after the first resection of ALTs of the extremity with or without adjuvant radiation. Methods. A dual
Externí odkaz:
https://doaj.org/article/07a41de342ff435294844b3f6ae010fc
Publikováno v:
Trends in Biochemical Sciences. 48:450-462