Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Brian Onken"'
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008982 (2020)
High glucose diets are unhealthy, although the mechanisms by which elevated glucose is harmful to whole animal physiology are not well understood. In Caenorhabditis elegans, high glucose shortens lifespan, while chemically inflicted glucose restricti
Externí odkaz:
https://doaj.org/article/9b5eac76c8444e46bb5c4eb824df624c
Autor:
Mark Lucanic, W. Todd Plummer, Esteban Chen, Jailynn Harke, Anna C. Foulger, Brian Onken, Anna L. Coleman-Hulbert, Kathleen J. Dumas, Suzhen Guo, Erik Johnson, Dipa Bhaumik, Jian Xue, Anna B. Crist, Michael P. Presley, Girish Harinath, Christine A. Sedore, Manish Chamoli, Shaunak Kamat, Michelle K. Chen, Suzanne Angeli, Christina Chang, John H. Willis, Daniel Edgar, Mary Anne Royal, Elizabeth A. Chao, Shobhna Patel, Theo Garrett, Carolina Ibanez-Ventoso, June Hope, Jason L Kish, Max Guo, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face
Externí odkaz:
https://doaj.org/article/2cab827465544f808fc531ab3590aa8a
Autor:
Mehul Vora, Mitalie Shah, Silvana Ostafi, Brian Onken, Jian Xue, Julie Zhouli Ni, Sam Gu, Monica Driscoll
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003737 (2013)
Caloric/dietary restriction (CR/DR) can promote longevity and protect against age-associated disease across species. The molecular mechanisms coordinating food intake with health-promoting metabolism are thus of significant medical interest. We repor
Externí odkaz:
https://doaj.org/article/681881f70e31431a88d94fc2ab2b1037
Autor:
Brian Onken, Monica Driscoll
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8758 (2010)
Metformin, a biguanide drug commonly used to treat type-2 diabetes, has been noted to extend healthspan of nondiabetic mice, but this outcome, and the molecular mechanisms that underlie it, have received relatively little experimental attention. To d
Externí odkaz:
https://doaj.org/article/4093755665734042a2da0090360cc5d7
Publikováno v:
PLoS Genetics, Vol 4, Iss 2, p e24 (2008)
In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-regulating the nutrient-sensor TOR (Target Of Rapamycin). TOR inhibition elicits autophagy, the large-scale recycling of cytoplasmic macromolecules and organ
Externí odkaz:
https://doaj.org/article/a6fa573a97ca435d8cee88cb9e1048da
Autor:
Monica Driscoll, Brian Onken, Yunpeng Xu, Yuhua Song, Madhuri Achanta, Christine Sedore, Patrick Phillips, Gordon Lithgow
Publikováno v:
Innovation in Aging. 6:806-807
The Caenorhabditis Intervention Testing Program (CITP) seeks to identify robust and reproducible pro-longevity interventions affecting a genetically diverse panel of representative Caenorhabditis strains from each of 3 species – C. elegans, C. brig
Autor:
Stephen A. Banse, E. Grace Jackson, Christine A. Sedore, Brian Onken, David Hall, Anna Coleman-Hulbert, Phu Huynh, Theo Garrett, Erik Johnson, Girish Harinath, Delaney Inman, Suzhen Guo, Mackenzie Morshead, Jian Xue, Ron Falkowski, Esteban Chen, Christopher Herrera, Allie J Kirsch, Viviana I. Perez, Max Guo, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips
Aging is characterized by declining health that results in decreased neuromuscular function and cellular resilience. The relationship between lifespan and health, and the influence of genetic background on that relationship, has important implication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9c5e51f2089bf93eafc4f6456bc8a92
https://doi.org/10.1101/2022.01.15.476462
https://doi.org/10.1101/2022.01.15.476462
Autor:
Xiaoying Zhang, Qingrong Huang, Chen Hongzhang, Monica Driscoll, Yong Cao, Brian Onken, Chen Yunjiao
Publikováno v:
Food & Function. 11:2439-2450
Oenothein B (OEB) exhibits extensive biological activities, but few investigations have been carried out on the pharmacologic influence of OEB on longevity in any organism. To explore the potential pharmacological ability of OEB to postpone the progr
Autor:
Gordon J. Lithgow, Patrick C. Phillips, Mackenzie L Morshead, Brian Onken, June Hope, Elizabeth A. Chao, Erik Johnson, David Hall, Stephen A. Banse, Christine A Sedore, Esteban Chen, Phu Huynh, Todd Plummer, Anna C. Foulger, Suzhen Guo, Eleanor Grace Jones, Max Guo, Monica Driscoll, Delaney Inman, Anna L. Coleman-Hulbert, Dipa Bhaumik, Jian Xue, Girish Harinath
Publikováno v:
Aging Cell
Metformin, the most commonly prescribed anti‐diabetes medication, has multiple reported health benefits, including lowering the risks of cardiovascular disease and cancer, improving cognitive function with age, extending survival in diabetic patien
Autor:
Anna C. Foulger, Jian Xue, D. Inman, Manish Chamoli, Michelle K. Chen, M. O. Schmidt, Gordon J. Lithgow, R. P. Quinn, Patrick C. Phillips, Suzhen Guo, W. T. Plummer, Mark Lucanic, S. A. Banse, Brian Onken, Phu Huynh, Ron Falkowski, Erik Johnson, Emily Y. Chen, David Hall, Monica Driscoll, Anna L. Coleman-Hulbert, Max Guo, Mackenzie L Morshead, Christine A Sedore, Daniel Edgar, Dipa Bhaumik, Girish Harinath, E. G. Jackson, Theo Garrett
The Caenorhabditis Intervention Testing Program (CITP) is an NIH-funded research consortium of investigators who conduct analyses at three independent sites to identify chemical interventions that reproducibly promote health and lifespan in a robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84c65f00c3a041d6c5a1cf05e8ad25d8
https://doi.org/10.1101/2021.11.09.464847
https://doi.org/10.1101/2021.11.09.464847