Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Brian O. Bachmann"'
Autor:
David C. Earl, P. Brent Ferrell, Nalin Leelatian, Jordan T. Froese, Benjamin J. Reisman, Jonathan M. Irish, Brian O. Bachmann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Bioactive metabolites from plant and microbial extracts hold therapeutic potential. Here, the authors combine untargeted metabolomic arrays with flow cytometry-based single cell response profiling and identify metabolites with cell subset-specific ac
Externí odkaz:
https://doaj.org/article/b3bcc8bdbb794beeb2a498e7912fa5bb
Publikováno v:
Organic & Biomolecular Chemistry. 19:775-784
Herein we report the development of a new periodate-based reactive assay system for the fluorescent detection of the cis-diol metabolites produced by Rieske dioxygenases. This sensitive and diastereoselective assay system successfully evaluates the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d7cf8fa6ef24426d0414db4df097c8
https://doi.org/10.1039/d0ob02412k
https://doi.org/10.1039/d0ob02412k
Autor:
Haley E. Ramsey, Benjamin J. Reisman, Maria P. Arrate, Agnieszka E. Gorska, Londa Fuller, Brian O. Bachmann, Michael R. Savona
Publikováno v:
Blood. 140:5959-5960
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::492bf440d2eb11003c9fc116b2ad9418
https://doi.org/10.1182/blood-2022-162513
https://doi.org/10.1182/blood-2022-162513
Autor:
Joseph A. Balsamo, Kathryn E. Penton, Zhihan Zhao, Madeline J. Hayes, Sierra M. Lima, Jonathan M. Irish, Brian O. Bachmann
Publikováno v:
The Journal of biological chemistry. 298(9)
Natural products constitute and significantly impact many current anti-cancer medical interventions. A subset of natural products induces injury processes in malignant cells that recruit and activate host immune cells to produce an adaptive anti-canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa630620d24c269f588a9c0f74bdc9c4
https://pubmed.ncbi.nlm.nih.gov/35931117
https://pubmed.ncbi.nlm.nih.gov/35931117
Publikováno v:
Angew Chem Int Ed Engl
Herein, we report novel formic acid-mediated rearrangements of dearomatized acylphloroglucinols to access a structurally diverse group of synthetic acylphloroglucinol scaffolds (SASs). Density functional theory (DFT)-optimized orbital and stereochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543acbfe760c0be7eda9086bd5c91cd2
https://doi.org/10.1002/anie.202010338
https://doi.org/10.1002/anie.202010338
Autor:
Tina M. Iverson, Audrey E Ynigez-Gutierrez, Jeffrey M. Spraggins, Brian O. Bachmann, Emilianne M. Limbrick, Kathryn M. McCulloch, Dagmara K. Derewacz, Callie C Dulin
Publikováno v:
ChemBioChem. 21:3349-3358
Everninomicins are orthoester oligosaccharide antibiotics with potent activity against multidrug-resistant bacterial pathogens. Everninomicins act by disrupting ribosomal assembly in a distinct region in comparison to clinically prescribed drugs. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b393ce36c5526db696bfdaa0d55012
https://doi.org/10.1002/cbic.202000305
https://doi.org/10.1002/cbic.202000305
Publikováno v:
Anal Chem
Imaging the inventory of microbial small molecule interactions provides important insights into microbial chemical ecology and human medicine. Herein we demonstrate a new method for enhanced detection and analysis of metabolites present in interspeci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265bda541720d5392cead7e005384882
https://doi.org/10.1021/acs.analchem.9b02992
https://doi.org/10.1021/acs.analchem.9b02992
Autor:
Michael R. Savona, Paul Brent Ferrell, Bradley I. Reinfeld, Brian O. Bachmann, Madison T. Wright, Gary A. Sulikowski, Rathmell Wk, John L. Rubinstein, Lars Plate, Haiyang Guo, Benjamin J. Reisman, Haley E. Ramsey
Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards oncogene transformed cells, yet their molecular mechanism remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6461d9d11637bdcf143daa04267a41c1
https://doi.org/10.1101/2021.05.31.445492
https://doi.org/10.1101/2021.05.31.445492
Autor:
P. Brent Ferrell, Madison T. Wright, Benjamin J. Reisman, Lars Plate, Hui Guo, Bradley I. Reinfeld, Michael R. Savona, Brian O. Bachmann, Gary A. Sulikowski, W. Kimryn Rathmell, John L. Rubinstein, Haley E. Ramsey
Publikováno v:
Nature chemical biology. 18(4)
Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards oncogene-transformed cells, yet their molecular mechanism remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2a8eef8d7705a6ccd271bc4aa7588c
https://pubmed.ncbi.nlm.nih.gov/34857957
https://pubmed.ncbi.nlm.nih.gov/34857957
Publikováno v:
Cytometry A
Fluorescent cell barcoding (FCB) enables efficient collection of tens to hundreds of flow cytometry samples by covalently marking cells with varying concentration of spectrally distinct dyes. A key consideration in FCB is to balance the density of dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de344a21c8e32a2386f56d2545836a6e
https://pubmed.ncbi.nlm.nih.gov/33960644
https://pubmed.ncbi.nlm.nih.gov/33960644