Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Brian O. Smith"'
Autor:
Emily L Dearlove, Chatrin Chatrin, Lori Buetow, Syed F Ahmed, Tobias Schmidt, Martin Bushell, Brian O Smith, Danny T Huang
Publikováno v:
eLife, Vol 13 (2024)
Ubiquitination typically involves covalent linking of ubiquitin (Ub) to a lysine residue on a protein substrate. Recently, new facets of this process have emerged, including Ub modification of non-proteinaceous substrates like ADP-ribose by the DELTE
Externí odkaz:
https://doaj.org/article/5b3ec1b8f96542dbb84d56852204953f
Autor:
Annemette Kjeldsen, Jack E. Kay, Scott Baxter, Stephen McColm, Cristina Serrano‐Amatriain, Scott Parker, Ellis Robb, S. Alison Arnold, Craig Gilmour, Anna Raper, Graeme Robertson, Robert Fleming, Brian O. Smith, Ian G. Fotheringham, John M. Christie, Leonardo Magneschi
Publikováno v:
Microbial Biotechnology, Vol 15, Iss 7, Pp 2126-2139 (2022)
Summary The methylotrophic yeast Pichia pastoris is commonly used for the production of recombinant proteins at scale. The identification of an optimally overexpressing strain following transformation can be time and reagent consuming. Fluorescent re
Externí odkaz:
https://doaj.org/article/fb23b6d82d6f45a3b685a36c98b58246
Autor:
Apurva T. Prabhakar, Claire D. James, Dipon Das, Raymonde Otoa, Matthew Day, John Burgner, Christian T. Fontan, Xu Wang, Sarah H. Glass, Andreas Wieland, Mary M. Donaldson, Molly L. Bristol, Renfeng Li, Anthony W. Oliver, Laurence H. Pearl, Brian O. Smith, Iain M. Morgan
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers. In this report, we demonstrate that phosphorylation of HPV16 E2 by CK2 promotes f
Externí odkaz:
https://doaj.org/article/198e33f511a84547b225bf38fd4332b1
Publikováno v:
ACS Applied Nano Materials. 5:15362-15368
The maturation of spirit in wooden casks is key to the production of whisky, a hugely popular and valuable product, with the transfer and reaction of molecules from the wooden cask with the alcoholic spirit imparting color and flavor. However, time i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71db84524f2ddaa98903a68f3e81a371
https://doi.org/10.1021/acsanm.2c03406
https://doi.org/10.1021/acsanm.2c03406
Autor:
Hanna K. Buist, Urszula Luchowska-Stańska, Boy van Basten, Jessica Valli, Brian O. Smith, George S. Baillie, Colin Rickman, Bryon Ricketts, Alex Davidson, Ryan Hannam, Joanne Sunderland, Stephen J. Yarwood
Publikováno v:
Cells, Vol 10, Iss 9, p 2307 (2021)
An exchange protein directly activated by cAMP 1 (EPAC1) is an intracellular sensor for cAMP that is involved in a wide variety of cellular and physiological processes in health and disease. However, reagents are lacking to study its association with
Externí odkaz:
https://doaj.org/article/a89d1e2a0a6848fdafc5f56006531a1d
Autor:
Euan Parnell, Stuart P. McElroy, Jolanta Wiejak, Gemma L. Baillie, Alison Porter, David R. Adams, Holger Rehmann, Brian O. Smith, Stephen J. Yarwood
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Screening of a carefully selected library of 5,195 small molecules identified 34 hit compounds that interact with the regulatory cyclic nucleotide-binding domain (CNB) of the cAMP sensor, EPAC1. Two of these hits (I942 and I178) were selecte
Externí odkaz:
https://doaj.org/article/c91ea91952a24175bdc43cc328f5f816
Autor:
Sebastian Adam, Dazhong Zheng, Andreas Klein, Carsten Volz, William Mullen, Sally L. Shirran, Brian O. Smith, Olga V. Kalinina, Rolf Müller, Jesko Koehnke
Funding: This work was supported by the European Research Council (Consolidator Grant 101002326 to J.K.). Ribosomally synthesized and post-translationally modified peptide natural products have provided many highly unusual scaffolds. This includes th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82516f85766260d2c682e8f88992052
https://hdl.handle.net/10023/27337
https://hdl.handle.net/10023/27337
Autor:
Rhys Grinter, Inokentijs Josts, Khedidja Mosbahi, Aleksander W. Roszak, Richard J. Cogdell, Alexandre M. J. J. Bonvin, Joel J. Milner, Sharon M. Kelly, Olwyn Byron, Brian O. Smith, Daniel Walker
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Many bacteria use TonB-dependent outer membrane receptors to scavenge iron from their host during infection. Here, the authors report on the structure and function of FusA, which is a bacterial receptor that is used to obtain iron from plants.
Externí odkaz:
https://doaj.org/article/922bf10269c74726b44966df17a78a66
Autor:
Mark A. Nakasone, Karolina A. Majorek, Mads Gabrielsen, Gary J. Sibbet, Brian O. Smith, Danny T. Huang
Publikováno v:
Nature Chemical Biology. 18:422-431
Ubiquitin (Ub) chain types govern distinct biological processes. K48-linked polyUb chains target substrates for proteasomal degradation, but the mechanism of Ub chain synthesis remains elusive due to the transient nature of Ub handover. Here, we pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59b00b065e84f7df0c09e6f054c06098
https://doi.org/10.1038/s41589-021-00952-x
https://doi.org/10.1038/s41589-021-00952-x
Autor:
Stephanie M. Ryan, Roland Ruscher, Wayne A. Johnston, Darren A. Pickering, Malcolm W. Kennedy, Brian O. Smith, Linda Jones, Geraldine Buitrago, Matt A. Field, Adrian J. Esterman, Connor P. McHugh, Daniel J. Browne, Martha M. Cooper, Rachael Y. M. Ryan, Denise L. Doolan, Christian R. Engwerda, Kim Miles, Makedonka Mitreva, John Croese, Tony Rahman, Kirill Alexandrov, Paul R. Giacomin, Alex Loukas
Refereed/Peer-reviewed Parasitic helminth infections, while a major cause of neglected tropical disease burden, negatively correlate with the incidence of immune-mediated inflammatory diseases such as inflammatory bowel diseases (IBD). To evade expul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a06db3c726634b64000a0a47470ec5
https://eprints.gla.ac.uk/278828/1/278828.pdf
https://eprints.gla.ac.uk/278828/1/278828.pdf