Výsledky vyhledávání - "Brian Necela"

Akademický článek

Expression of c-erb-B2 oncoprotein as a neoantigen strategy to repurpose anti-neu antibody therapy in a model of melanoma

Autor: Emmanuel M. Gabriel, Brian Necela, Deborah Bahr, Sneha Vivekanandhan, Barath Shreeder, Sanjay Bagaria, Keith L. Knutson

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract In this study, we tested a novel approach of “repurposing” a biomarker typically associated with breast cancer for use in melanoma. HER2/neu is a well characterized biomarker in breast cancer for which effective anti-HER2/neu therapies a

Externí odkaz: https://doaj.org/article/15cf9697167549baa914c2e9e20348c7

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Akademický článek

Comprehensive profiling of cancer neoantigens from aberrant RNA splicing

Autor: Yi Lin, Yan W Asmann, Barath Shreeder, Keith L Knutson, Erik Jessen, Daniel P Wickland, Colton McNinch, Brian Necela

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)

Background Cancer neoantigens arise from protein-altering somatic mutations in tumor and rank among the most promising next-generation immuno-oncology agents when used in combination with immune checkpoint inhibitors. We previously developed a comput

Externí odkaz: https://doaj.org/article/bf5610643ea74733ae707eb219999a5b

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Supplementary Figure S3 from Mutant KRAS–Induced Expression of ICAM-1 in Pancreatic Acinar Cells Causes Attraction of Macrophages to Expedite the Formation of Precancerous Lesions

Autor: Peter Storz, David W. Dawson, Lizhi Zhang, Brandy Edenfield, Brian Necela, Heike Döppler, Geou-Yarh Liou

Supplementary Figure S3 shows analysis for microvascularization (A), alcian blue staining of tissue sections (B), and ICAM-1 expression in human samples (C).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a73fb173f17e77a8bc3f2449e01f3c
https://doi.org/10.1158/2159-8290.22530177.v1

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Supplementary Methods from Mutant KRAS–Induced Expression of ICAM-1 in Pancreatic Acinar Cells Causes Attraction of Macrophages to Expedite the Formation of Precancerous Lesions

Autor: Peter Storz, David W. Dawson, Lizhi Zhang, Brandy Edenfield, Brian Necela, Heike Döppler, Geou-Yarh Liou

Supplementary Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca71cc6bbfa84fc673ee79e2597013b0
https://doi.org/10.1158/2159-8290.22530165

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Data from Mutant KRAS–Induced Expression of ICAM-1 in Pancreatic Acinar Cells Causes Attraction of Macrophages to Expedite the Formation of Precancerous Lesions

Autor: Peter Storz, David W. Dawson, Lizhi Zhang, Brandy Edenfield, Brian Necela, Heike Döppler, Geou-Yarh Liou

Desmoplasia and an inflammatory environment are defining features of pancreatic cancer. Unclear is how pancreatic cells that undergo oncogenic transformation can cross-talk with immune cells and how this contributes to the development of pancreatic l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd46ad8072666f3a666a670952d43110
https://doi.org/10.1158/2159-8290.c.6546120

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Abstract 5371: Repurposing erbb2 (HER2/neu) as a neoantigen target for neu-negative tumors using a novel erbb2-encoding lentivirus

Autor: Emmanuel M. Gabriel, Brian Necela, Deborah Bahr, Jamie Kaplan, Kristopher Attwood, Keith Knutson

Publikováno v: Cancer Research. 82:5371-5371

INTRODUCTION: HER2/neu is a potent biomarker for which anti-HER2/neu antibodies offer significant responses. However, many cancers, such as melanoma, have less than 5% expression of HER2/neu. The purpose of this study was to determine whether induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed43d8c15998f40cb9f31b6ec580963b
https://doi.org/10.1158/1538-7445.am2022-5371

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