Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Brian N. Finck"'
Autor:
Abdulrahman Jama, Abdullah A. Alshudukhi, Steve Burke, Lixin Dong, John Karanja Kamau, Brooklyn Morris, Ibrahim A. Alkhomsi, Brian N. Finck, Andrew Alvin Voss, Hongmei Ren
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Duchenne muscular dystrophy (DMD) is a progressive and devastating muscle disease, resulting from the absence of dystrophin. This leads to cell membrane instability, susceptibility to contraction-induced muscle damage, subsequent
Externí odkaz:
https://doaj.org/article/e1d4da805e9b453fa9ff3ce6ee88fb29
Autor:
Alexandra Brown, Brooklyn Morris, John Karanja Kamau, Ryan J. Rakoczy, Brian N. Finck, Christopher N. Wyatt, Hongmei Ren
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
In Duchenne muscular dystrophy (DMD), diaphragm muscle dysfunction results in respiratory insufficiency which is a leading cause of death in patients. Mutations to the dystrophin gene result in myocyte membrane instability, contributing to the struct
Externí odkaz:
https://doaj.org/article/d3cdca8b3ea04555a7a1aead4a3d8638
Autor:
Jiameng Sun, Yiming Zhang, Joshua A. Adams, Cassandra B. Higgins, Shannon C. Kelly, Hao Zhang, Kevin Y. Cho, Ulysses G. Johnson, Benjamin M. Swarts, Shun-Ichi Wada, Gary J. Patti, Leah P. Shriver, Brian N. Finck, Erik D. Herzog, Brian J. DeBosch
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114865- (2024)
Summary: Organisms integrate circadian and metabolic signals to optimize substrate selection to survive starvation, yet precisely how this occurs is unclear. Here, we show that hepatocyte Period 1 (Per1) is selectively induced during fasting, and mic
Externí odkaz:
https://doaj.org/article/f3f84b6930c6468d8267aafa1547506a
Autor:
Kim H. H. Liss, Muhammad Mousa, Shria Bucha, Andrew Lutkewitte, Jeremy Allegood, L. Ashley Cowart, Brian N. Finck
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Liver failure secondary to metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common cause for liver transplantation in many parts of the world. Moreover, the prevalence of MASLD not only increases the deman
Externí odkaz:
https://doaj.org/article/5e48b89e7cc74125961d1b3caf57ad4d
Autor:
Kendall H. Burks, Yan Xie, Michael Gildea, In-Hyuk Jung, Sandip Mukherjee, Paul Lee, Upasana Pudupakkam, Ryan Wagoner, Ved Patel, Katherine Santana, Arturo Alisio, Ira J. Goldberg, Brian N. Finck, Edward A. Fisher, Nicholas O. Davidson, Nathan O. Stitziel
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100500- (2024)
Angiopoietin-like protein 3 (ANGPTL3) is a hepatically secreted protein and therapeutic target for reducing plasma triglyceride-rich lipoproteins and low-density lipoprotein (LDL) cholesterol. Although ANGPTL3 modulates the metabolism of circulating
Externí odkaz:
https://doaj.org/article/0bbb8760625945f68aa390901c0e6cd2
Autor:
Zhouji Chen, Shiyu Wang, Anita Pottekat, Alec Duffey, Insook Jang, Benny H. Chang, Jaehyung Cho, Brian N. Finck, Nicholas O. Davidson, Randal J. Kaufman
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101874- (2024)
Objectives: The assembly and secretion of hepatic very low-density lipoprotein (VLDL) plays pivotal roles in hepatic and plasma lipid homeostasis. Protein disulfide isomerase A1 (PDIA1/P4HB) is a molecular chaperone whose functions are essential for
Externí odkaz:
https://doaj.org/article/2eb00029f7a54fa383e62a065aa4cf9b
Autor:
Nicole K.H. Yiew, Stanislaw Deja, Daniel Ferguson, Kevin Cho, Chaowapong Jarasvaraparn, Miriam Jacome-Sosa, Andrew J. Lutkewitte, Sandip Mukherjee, Xiaorong Fu, Jason M. Singer, Gary J. Patti, Shawn C. Burgess, Brian N. Finck
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108196- (2023)
Summary: The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing lipids via de novo lipogenesis (DNL) when carbohydrates are abundant. Mitochondria
Externí odkaz:
https://doaj.org/article/802c3f379cbe48bdb9a10949ed2a6500
Autor:
Mandy M. Chan, Sabine Daemen, Joseph W. Beals, Marina Terekhova, Bin Q. Yang, Christina F. Fu, Li He, Arick C. Park, Gordon I. Smith, Babak Razani, Kathleen Byrnes, Wandy L. Beatty, Shaina R. Eckhouse, J. Christopher Eagon, Daniel Ferguson, Brian N. Finck, Samuel Klein, Maxim N. Artyomov, Joel D. Schilling
Publikováno v:
JHEP Reports, Vol 5, Iss 11, Pp 100877- (2023)
Background & Aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common complication of obesity with a hallmark feature of hepatic steatosis. Recent data from animal models of MAFLD have demonstrated substantial changes in macroph
Externí odkaz:
https://doaj.org/article/899e9858356b4c83b39c77d67e35c9a8
Autor:
Nicole K.H. Yiew, Joel H. Vazquez, Michael R. Martino, Stefanie Kennon-McGill, Jake R. Price, Felicia D. Allard, Eric U. Yee, Alexander J. Layman, Laura P. James, Kyle S. McCommis, Brian N. Finck, Mitchell R. McGill
Publikováno v:
Molecular Metabolism, Vol 77, Iss , Pp 101808- (2023)
Objective: Mitochondrial pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, and NADH production. As a result, the mitochondrial pyruvate carrier (MPC) complex has emerged as a promising therapeutic target in metabolic dis
Externí odkaz:
https://doaj.org/article/d6d71cdcd46e41c5bc9d71d91d69be47
Autor:
Sandip Mukherjee, Molee Chakraborty, Eliwaza N. Msengi, Jake Haubner, Jinsong Zhang, Matthew J. Jellinek, Haley L. Carlson, Kelly Pyles, Barbara Ulmasov, Andrew J. Lutkewitte, Danielle Carpenter, Kyle S. McCommis, David A. Ford, Brian N. Finck, Brent A. Neuschwander-Tetri, Anutosh Chakraborty
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101767- (2023)
Objective: Defining the regulators of cell metabolism and signaling is essential to design new therapeutic strategies in obesity and NAFLD/NASH. E3 ubiquitin ligases control diverse cellular functions by ubiquitination-mediated regulation of protein
Externí odkaz:
https://doaj.org/article/b2642d46704a4c24822cb884661aab61