Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Brian N Chorley"'
Autor:
John Rooney, Keiyu Oshida, Naresh Vasani, Beena Vallanat, Natalia Ryan, Brian N Chorley, Xuting Wang, Douglas A Bell, Kai C Wu, Lauren M Aleksunes, Curtis D Klaassen, Thomas W Kensler, J Christopher Corton
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200004 (2018)
The transcription factor Nrf2 (encoded by Nfe2l2) induces expression of numerous detoxifying and antioxidant genes in response to oxidative stress. The cytoplasmic protein Keap1 interacts with and represses Nrf2 function. Computational approaches wer
Externí odkaz:
https://doaj.org/article/12b78834e2874996bc7bdf6228ed92c1
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155875 (2016)
Determining mechanism-based biomarkers that distinguish adaptive and adverse cellular processes is critical to understanding the health effects of environmental exposures. Shifting from in vivo, low-throughput toxicity studies to high-throughput scre
Externí odkaz:
https://doaj.org/article/d661d7a775e34c2b829511a815d7d02d
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundMechanistic understanding of transient exposures that lead to adverse health outcomes will enhance our ability to recognize biological signatures of disease. Here, we measured the transcriptomic and epigenomic alterations due to exposure to
Externí odkaz:
https://doaj.org/article/51af5221d82a4dbfae9bc844350e6dd7
Autor:
Xuting Wang, Brian N Chorley, Gary S Pittman, Steven R Kleeberger, John Brothers, Gang Liu, Avrum Spira, Douglas A Bell
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e11934 (2010)
Prior microarray studies of smokers at high risk for lung cancer have demonstrated that heterogeneity in bronchial airway epithelial cell gene expression response to smoking can serve as an early diagnostic biomarker for lung cancer. As a first step
Externí odkaz:
https://doaj.org/article/920782602b294c528d9f271cb06baab0
Autor:
Maher A Noureddine, Daniel Menendez, Michelle R Campbell, Omari J Bandele, Monica M Horvath, Xuting Wang, Gary S Pittman, Brian N Chorley, Michael A Resnick, Douglas A Bell
Publikováno v:
PLoS Genetics, Vol 5, Iss 5, p e1000462 (2009)
The p53 tumor suppressor regulates its target genes through sequence-specific binding to DNA response elements (REs). Although numerous p53 REs are established, the thousands more identified by bioinformatics are not easily subjected to comparative f
Externí odkaz:
https://doaj.org/article/c25bbce90e3945b88637a8ae0d552b94
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 805-815 (2020)
MicroRNAs (miRNAs) are short non-coding RNA species that play key roles in post-transcriptional regulation of gene expression. MiRNAs also serve as a promising source of early biomarkers for different environmental exposures and health effects, altho
Externí odkaz:
https://doaj.org/article/a9271998c08d4068b9fb687ebf508ef9
Autor:
Yue Ge, Maribel Bruno, Maliha S Nash, Najwa Haykal Coates, Brian N Chorley, Matthew C Cave, Juliane I Beier
Publikováno v:
Toxicol Sci
Alterations in physiological processes in pancreas have been associated with various metabolic dysfunctions and can result from environmental exposures, such as chemicals and diet. It was reported that environmental vinyl chloride (VC) exposure, a co
Autor:
Colette N. Miller, Janice A. Dye, Andres R. Henriquez, Erica J. Stewart, Katelyn S. Lavrich, Gleta K. Carswell, Hongzu Ren, Danielle L. Freeborn, Samantha J. Snow, Mette C. Schladweiler, Judy H. Richards, Prasada R.S. Kodavanti, Anna Fisher, Brian N. Chorley, Urmila P. Kodavanti
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101094- (2020)
Objective: The importance of the placenta in mediating the pre- and post-natal consequences of fetal growth restriction has been increasingly recognized. However, the influence of placental sexual dimorphism on driving these outcomes has received lit
Externí odkaz:
https://doaj.org/article/73c131e86c90402da0e2dccd539c9d46
Autor:
Gail M. Nelson, Brian N. Chorley
Publikováno v:
Genomic and Epigenomic Biomarkers of Toxicology and Disease. :7-35
Urinary miRNA Biomarkers of Drug-Induced Kidney Injury and Their Site Specificity Within the Nephron
Autor:
Heidrun Ellinger-Ziegelbauer, Connie L Chen, Jean-François Léonard, Michael R. Tackett, James Eric McDuffie, Elnaz Atabakhsh, Ernie Harpur, Rounak Nassirpour, Brian N. Chorley, Laurence O. Whiteley, Gleta Carswell, Alison H. Harrill, Jean-Charles Gautier, Frank J. Simutis
Publikováno v:
Toxicological Sciences
Drug-induced kidney injury (DIKI) is a major concern in both drug development and clinical practice. There is an unmet need for biomarkers of glomerular damage and more distal renal injury in the loop of Henle and the collecting duct (CD). A cross-la