Plasma membrane preassociation drives β-arrestin coupling to receptors and activation

Autor: Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Tamara Miljus, Shannon L. O’Brien, Tomasz M. Stepniewski, Brian Medel-Lacruz, Mithu Baidya, Maria Makarova, Ravi Mistry, Joëlle Goulding, Julia Drube, Carsten Hoffmann, Dylan M. Owen, Arun K. Shukla, Jana Selent, Stephen J. Hill, Davide Calebiro

Publikováno v: Cell

β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor-β-arrestin interactions at the plasma membrane of living cells remain elusive. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df63d5d439e67b15630e00bb403cf9c
https://europepmc.org/articles/PMC7614532/

Single-molecule analysis of receptor-β-arrestin interactions in living cells

Autor: Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Tamara Miljus, Shannon L. O’Brien, Tomasz M Stepniewski, Brian Medel-Lacruz, Mithu Baidya, Maria Makarova, Dylan M. Owen, Arun K. Shukla, Jana Selent, Stephen J. Hill, Davide Calebiro

SUMMARYβ-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor–β-arrestin interactions at the plasma membrane of living cells remain e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38f96ef53e7d5824aea2949dbeef178f
https://doi.org/10.1101/2022.11.15.516577

Simulating Time-Resolved Dynamics of Biomolecular Systems

Autor: David Aranda-Garcia, Mariona Torrens-Fontanals, Brian Medel-Lacruz, Marta Lopez-Balastegui, Alejandro Peralta-García, Miguel Dieguez-Eceolaza, Adrian Morales-Pastor, David Sotillo-Núñez, Davide Abbondandolo, Tomasz Maciej Stępniewski, Jana Selent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28c15e10662c53a0218dfbdaf71705a6
https://doi.org/10.1016/b978-0-12-820472-6.00214-0

GPCRmd uncovers the dynamics of the 3D-GPCRome

Autor: Minos-Timotheos Matsoukas, David E. Gloriam, Ismael Rodríguez-Espigares, Agnieszka Sztyler, Davide Provasi, Arnau Cordomí, Peter Kolb, David Aranda-García, Toni Giorgino, Ferran Sanz, Mariona Torrens-Fontanals, Peter W. Hildebrand, Maria Marti-Solano, Mireia Olivella, Alejandro Varela-Rial, Gianni De Fabritiis, José Carlos Gómez-Tamayo, Laura Pérez-Benito, Tomasz Maciej Stepniewski, Eduardo Mayol, Silvana Vasile, Slawomir Filipek, Ulrich Zachariae, Jens Carlsson, Dorota Latek, Harel Weinstein, Gáspár Pándy-Szekeres, Przemyslaw Miszta, Willem Jespers, Nathalie Worp, Mireia Jiménez-Rosés, Juan Manuel Ramírez-Anguita, Marta Filizola, George Khelashvili, Angel Gonzalez, Brian Medel Lacruz, Pierre Matricon, Iván Rodríguez-Torrecillas, Xavier Deupi, Adrián Morales-Pastor, Jessica Sallander, Hugo Gutiérrez-de-Terán, Johanna K. S. Tiemann, Jana Selent, Jon Kapla, Ramon Guixà-González, Santiago Ríos

Publikováno v: Nature Methods
Nature methods (Online) 17 (2020): 777–787. doi:10.1038/s41592-020-0884-y
info:cnr-pdr/source/autori:Rodríguez-Espigares, Ismael; Torrens-Fontanals, Mariona; Tiemann, Johanna K.S.; Aranda-García, David; Ramírez-Anguita, Juan Manuel; Stepniewski, Tomasz Maciej; Worp, Nathalie; Varela-Rial, Alejandro; Morales-Pastor, Adrián; Medel-Lacruz, Brian; Pándy-Szekeres, Gáspár; Mayol, Eduardo; Giorgino, Toni; Carlsson, Jens; Deupi, Xavier; Filipek, Slawomir; Filizola, Marta; Gómez-Tamayo, José Carlos; Gonzalez, Angel; Gutiérrez-de-Terán, Hugo; Jiménez-Rosés, Mireia; Jespers, Willem; Kapla, Jon; Khelashvili, George; Kolb, Peter; Latek, Dorota; Marti-Solano, Maria; Matricon, Pierre; Matsoukas, Minos Timotheos; Miszta, Przemyslaw; Olivella, Mireia; Perez-Benito, Laura; Provasi, Davide; Ríos, Santiago; R. Torrecillas, Iván; Sallander, Jessica; Sztyler, Agnieszka; Vasile, Silvana; Weinstein, Harel; Zachariae, Ulrich; Hildebrand, Peter W.; De Fabritiis, Gianni; Sanz, Ferran; Gloriam, David E.; Cordomi, Arnau; Guixà-González, Ramon; Selent, Jana/titolo:GPCRmd uncovers the dynamics of the 3D-GPCRome/doi:10.1038%2Fs41592-020-0884-y/rivista:Nature methods (Online)/anno:2020/pagina_da:777/pagina_a:787/intervallo_pagine:777–787/volume:17

G-protein-coupled receptors (GPCRs) are involved in numerous physiological processes and are the most frequent targets of approved drugs. The explosion in the number of new three-dimensional (3D) molecular structures of GPCRs (3D-GPCRome) over the la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb6367e2808eb6eb81235f76f7853ad

In silico study of allosteric communication networks in GPCR signaling bias

Autor: Adrian Morales-Pastor, Francho Nerín-Fonz, David Aranda-García, Miguel Dieguez-Eceolaza, Brian Medel-Lacruz, Mariona Torrens-Fontanals, Alejandro Peralta-García, Jana Selent

Signaling bias is a promising characteristic of G protein-coupled receptors (GPCRs) as it provides the opportunity to develop more efficacious and safer drugs. This is because biased ligands can avoid the activation of pathways linked to side effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b057739a7a6ae4b8ef63b588e419b7d9
http://hdl.handle.net/10230/55490