Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brian M. Woolums"'
Autor:
Brian M. Woolums, Brett A. McCray, Hyun Sung, Masashi Tabuchi, Jeremy M. Sullivan, Kendra Takle Ruppell, Yunpeng Yang, Catherine Mamah, William H. Aisenberg, Pamela C. Saavedra-Rivera, Bryan S. Larin, Alexander R. Lau, Douglas N. Robinson, Yang Xiang, Mark N. Wu, Charlotte J. Sumner, Thomas E. Lloyd
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Mutations in the TRPV4 channel cause inherited neurodegeneration syndromes, but the molecular mechanisms are unknown. Here the authors reveal that TRPV4 activation causes dose-dependent, CaMKII-mediated neuronal dysfunction and axonal degeneration vi
Externí odkaz:
https://doaj.org/article/27caf567bfbb4b33b6d71b47ffe0ae8f
Autor:
Charlotte J. Sumner, Mark N. Wu, Pamela C. Saavedra-Rivera, Jeremy M. Sullivan, Douglas N. Robinson, Kendra Takle Ruppell, Brian M. Woolums, Alexander R. Lau, Thomas E. Lloyd, Catherine Mamah, Brett A. McCray, Masashi Tabuchi, Yunpeng Yang, Hyun Sung, William H. Aisenberg, Yang Xiang, Bryan S. Larin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The cation channel transient receptor potential vanilloid 4 (TRPV4) is one of the few identified ion channels that can directly cause inherited neurodegeneration syndromes, but the molecular mechanisms are unknown. Here, we show that in vivo expressi
Publikováno v:
Brain Research. 1693:55-66
Mutations in the nuclear localization signal of the RNA binding protein FUS cause both Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). These mutations result in a loss of FUS from the nucleus and the formation of FUS-containing
Autor:
Amy Schoenhofen, Alex J. McQuown, G. W. Gant Luxton, Nathan J. Harris, Howard J. Worman, Brian M. Woolums, Gregg G. Gundersen, Patrick T. Willey, Cosmo A. Saunders, William T. Dauer, Yuexia Wang
Publikováno v:
The Journal of Cell Biology
In fibroblasts and myoblasts polarizing for migration, retrograde actin flow moves the nucleus rearward, orienting the centrosome toward the leading edge. The nucleus engages moving dorsal actin cables through linear arrays of nesprin-2G and SUN2 cal
Autor:
Brian M, Woolums, Brett A, McCray, Hyun, Sung, Masashi, Tabuchi, Jeremy M, Sullivan, Kendra Takle, Ruppell, Yunpeng, Yang, Catherine, Mamah, William H, Aisenberg, Pamela C, Saavedra-Rivera, Bryan S, Larin, Alexander R, Lau, Douglas N, Robinson, Yang, Xiang, Mark N, Wu, Charlotte J, Sumner, Thomas E, Lloyd
Publikováno v:
Nature communications. 11(1)
The cation channel transient receptor potential vanilloid 4 (TRPV4) is one of the few identified ion channels that can directly cause inherited neurodegeneration syndromes, but the molecular mechanisms are unknown. Here, we show that in vivo expressi
Autor:
Shanshan Zhu, Brian M. Woolums, Natalya Zaika, Chi Tso Chiu, Paul M. Jenkins, Evan J. Hess, Kellie L.K. Tamashiro, Tae Yeon Kim, Yanning Zuo, De-Maw Chuang, Mikhail M. Pletnikov, Christopher A. Ross, Arabiye Artola, Andrew D. Nelson, Jiali Xiong, Zachary A. Cordner, Xiaofang Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(39)
Genome-wide association studies have implicated the ANK3 locus in bipolar disorder, a major human psychotic illness. ANK3 encodes ankyrin-G, which organizes the neuronal axon initial segment (AIS). We generated a mouse model with conditional disrupti
Autor:
Nathan J. Harris, Amy Schoenhofen, Baila Elkin, Natalie E. Cain, Brian M. Woolums, Hongyan Hao, Daniel A. Starr, Zeinab Jahed, Venecia A. Valdez, Leslie A Herrera, G. W. Gant Luxton, Mohammad R. K. Mofrad
Publikováno v:
Current biology : CB, vol 28, iss 19
Cain, NE; Jahed, Z; Schoenhofen, A; Valdez, VA; Elkin, B; Hao, H; et al.(2018). Conserved SUN-KASH Interfaces Mediate LINC Complex-Dependent Nuclear Movement and Positioning. Current Biology, 28(19), 3086-3097.e4. doi: 10.1016/j.cub.2018.08.001. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/4d50b0dp
Cain, NE; Jahed, Z; Schoenhofen, A; Valdez, VA; Elkin, B; Hao, H; et al.(2018). Conserved SUN-KASH Interfaces Mediate LINC Complex-Dependent Nuclear Movement and Positioning. Current Biology, 28(19), 3086-3097.e4. doi: 10.1016/j.cub.2018.08.001. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/4d50b0dp
© 2018 Elsevier Ltd Many nuclear positioning events involve linker of nucleoskeleton and cytoskeleton (LINC) complexes, which transmit forces generated by the cytoskeleton across the nuclear envelope. LINC complexes are formed by trans-luminal inter