Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Brian M. Wiczer"'
Autor:
Brian M. Wiczer, David A. Bernlohr
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 12, Pp 2502-2513 (2009)
Fatty acid transport proteins (FATPs) are integral membrane acyl-CoA synthetases implicated in adipocyte fatty acid influx and esterification. Whereas some FATP1 translocates to the plasma membrane in response to insulin, the majority of FATP1 remain
Externí odkaz:
https://doaj.org/article/d5dc6b8da021417a99fda4c2061f59a1
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 3, Pp 609-620 (2007)
The role of fatty acid transport protein 1 (FATP1) and FATP4 in facilitating adipocyte fatty acid metabolism was investigated using stable FATP1 or FATP4 knockdown (kd) 3T3-L1 cell lines derived from retrovirus-delivered short hairpin RNA (shRNA). De
Externí odkaz:
https://doaj.org/article/a1beea80fd934d9d8cc9bcc5b1d62b40
Publikováno v:
Stem Cells International, Vol 2017 (2017)
Stem Cells International
Stem Cells International
Human pluripotent stem cells derived cardiomyocytes (PSC-CMs) have been widely used for disease modeling, drug safety screening, and preclinical cell therapy to regenerate myocardium. Most studies have utilized PSC-CM grown in vitro for a relatively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd7a315db6ece53a01c413f4deb71b9
https://doaj.org/article/f512aa1509de4709ad70a39b9d16dd6b
https://doaj.org/article/f512aa1509de4709ad70a39b9d16dd6b
Publikováno v:
Molecular and Cellular Biology. 34:2890-2902
Mitochondrial calcium uptake stimulates bioenergetics and drives energy production in metabolic tissue. It is unknown how a calcium-mediated acceleration in matrix bioenergetics would influence cellular metabolism in glycolytic cells that do not requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70f4f8beb01b98f42a9928021d4d87d7
https://doi.org/10.1128/mcb.00068-14
https://doi.org/10.1128/mcb.00068-14
Publikováno v:
Biochemical and Biophysical Research Communications. 444:44-49
The isothiourea derivative, KB-R7943, inhibits the reverse-mode of the plasma membrane sodium/calcium exchanger and protects against ischemia/reperfusion injury. The mechanism through which KB-R7943 confers protection, however, remains controversial.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcfa5ce545157a8764f6c1833c3e8c7
https://doi.org/10.1016/j.bbrc.2014.01.009
https://doi.org/10.1016/j.bbrc.2014.01.009
Autor:
Olga Ilkayeva, Xin Xu, Wendy Wright, Deborah E. Muoio, Brian M. Wiczer, Paul A. Grimsrud, David A. Bernlohr, David W. Graham, Edgar A. Arriaga, Katherine Cianflone, Jonathan R. Brestoff, Jessica Curtis, Rocio Foncea
Publikováno v:
Diabetes
OBJECTIVE Peripheral insulin resistance is linked to an increase in reactive oxygen species (ROS), leading in part to the production of reactive lipid aldehydes that modify the side chains of protein amino acids in a reaction termed protein carbonyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79729ab3e11b2f44f941ca397f47c4d
http://europepmc.org/articles/PMC2857893
http://europepmc.org/articles/PMC2857893
Publikováno v:
Biochemical and Biophysical Research Communications. 387:234-238
Fatty acid transport proteins are integral membrane acyl-CoA synthetases implicated in adipocyte fatty acid influx and esterification. FATP-dependent production of AMP was evaluated using FATP4 proteoliposomes, and fatty acid-dependent activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc11ed80f927e0e8d28d1da4057ffbf5
https://doi.org/10.1016/j.bbrc.2009.06.114
https://doi.org/10.1016/j.bbrc.2009.06.114
Autor:
Ping Zhang, John Fassett, Guangshuo Zhu, Yingjie Chen, Brian M. Wiczer, David A. Bernlohr, Xin Xu, Benoit Viollet, Xinli Hu, Wayne Xu, Robert J. Bache
Publikováno v:
Hypertension. 52:918-924
AMP activated protein kinase (AMPK) plays an important role in regulating myocardial metabolism and protein synthesis. Activation of AMPK attenuates hypertrophy in cultured cardiac myocytes, but the role of AMPK in regulating the development of myoca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d97cff1e2d0965ba02dc7eea733e170
https://doi.org/10.1161/hypertensionaha.108.114702
https://doi.org/10.1161/hypertensionaha.108.114702
Publikováno v:
Future Lipidology. 1:291-298
The influx of diet-derived free fatty acids into adipose tissue leads to a variety of metabolic and regulatory responses that affect both the development of obesity and the homeostatic mechanisms linked to adipocytokine synthesis and secretion, as we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::687e9e81a4f74f9ec296e58f411b5582
https://doi.org/10.2217/17460875.1.3.291
https://doi.org/10.2217/17460875.1.3.291
Publikováno v:
Journal of Membrane Biology. 211:101-113
Four amino acids critical for lactose permease function were altered using site-directed mutagenesis. The resulting Quad mutant (E269Q/R302L/H322Q/E325Q) was expressed at 60% of wild-type levels but found to have negligible transport activity. The Qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac2db77b68656e1c4ca8b41df6c0089
https://doi.org/10.1007/s00232-005-7020-x
https://doi.org/10.1007/s00232-005-7020-x