Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Brian M. Wasko"'
Autor:
Carine Beaupere, Brian M. Wasko, Jared Lorusso, Brian K. Kennedy, Matt Kaeberlein, Vyacheslav M. Labunskyy
Publikováno v:
Cell Reports, Vol 18, Iss 8, Pp 1884-1892 (2017)
Transcriptional regulation plays an important role in the control of gene expression during aging. However, translation efficiency likely plays an equally important role in determining protein abundance, but it has been relatively understudied in thi
Externí odkaz:
https://doaj.org/article/bffcdf2940bf49a0b7a1dcacbe9b2170
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 11, Pp 1957-1964 (2011)
Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and disruption of protein prenyla
Externí odkaz:
https://doaj.org/article/4c963cc7175b43368438fe948ffb6940
Autor:
Alaattin Kaya, Cheryl Zi Jin Phua, Mitchell Lee, Lu Wang, Alexander Tyshkovskiy, Siming Ma, Benjamin Barre, Weiqiang Liu, Benjamin R Harrison, Xiaqing Zhao, Xuming Zhou, Brian M Wasko, Theo K Bammler, Daniel EL Promislow, Matt Kaeberlein, Vadim N Gladyshev
Publikováno v:
eLife, Vol 10 (2021)
To understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or ecologically diverse isolates of the same species, within a controlled environment. In particular,
Externí odkaz:
https://doaj.org/article/a23ce55a348841cb82af4f69eb2572cd
Autor:
Michael G. Kiflezghi, Sunny Nguyen, Mary Ann K. Li, Socheata Thon, Brian M. Wasko, Yordanos C. Elala, Matt Kaeberlein, Daniel E. L. Promislow, Katherine A. Grayden, Thu H. B. Tran, Mitsuhiro Tsuchiya, Yan Ting Zhao, Irika Sinha, Mitchell B. Lee, Deborah Kim, Karl Rodriguez, Ngoc Han Tran, Daniel T. Carr, Jesse Wang, Tu Anh Nguyen, Thao T Tang, Margarete D. Moore, Priya Ragosti, Priya A. Uppal
Publikováno v:
GeroScience
As the molecular mechanisms of biological aging become better understood, there is growing interest in identifying interventions that target those mechanisms to promote extended health and longevity. The budding yeast Saccharomyces cerevisiae has ser
Autor:
Christopher F Bennett, Jane J Kwon, Christine Chen, Joshua Russell, Kathlyn Acosta, Nikolay Burnaevskiy, Matthew M Crane, Alessandro Bitto, Helen Vander Wende, Marissa Simko, Victor Pineda, Ryan Rossner, Brian M Wasko, Haeri Choi, Shiwen Chen, Shirley Park, Gholamali Jafari, Bryan Sands, Carissa Perez Olsen, Alexander R Mendenhall, Philip G Morgan, Matt Kaeberlein
Publikováno v:
PLoS Genetics, Vol 13, Iss 3, p e1006695 (2017)
Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanisms exist to cope with disruptions to mitochondrial function that promote cellular health and organismal longevity. Previously,
Externí odkaz:
https://doaj.org/article/16244a054fa74a9d8488d864fa5e9844
Autor:
Daniel E. L. Promislow, Siming Ma, Theo K. Bammler, Cheryl Zi Jin Phua, Benjamin Barré, Xiaqing Zhao, Matt Kaeberlein, Xuming Zhou, Benjamin R Harrison, Brian M. Wasko, Lu Wang, Vadim N. Gladyshev, Weiqiang Liu, Mitchell B. Lee, Alexander Tyshkovskiy, Alaattin Kaya
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ee2cff85e12e769419d2322b3e6f71e
https://doi.org/10.7554/elife.64860.sa2
https://doi.org/10.7554/elife.64860.sa2
Autor:
Theo K. Bammler, Matt Kaeberlein, Benjamin Barré, Vadim N. Gladyshev, Xuming Zhou, Benjamin R Harrison, Cheryl Zi Jin Phua, Weiqiang Liu, Siming Ma, Daniel E. L. Promislow, Xiaqing Zhao, Lu Wang, Mitchell B. Lee, Brian M. Wasko, Alexander Tyshkovskiy, Alaattin Kaya
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
To understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or ecologically diverse isolates of the same species, within a controlled environment. In particular,
Autor:
Scott R. Kennedy, Alan J. Herr, Thu H. B. Tran, Ian T. Dowsett, Mitchell B. Lee, Niloufar Ghodsian, Anh B. Diep, Michael G. Kiflezghi, Michael S. Chung, Daniel T. Carr, Katherine A. Grayden, Anna Bode, Thao T Tang, Priya A. Uppal, Daniel E. L. Promislow, Ngoc Han Tran, Brian M. Wasko, Sarah G. Stanton, Yordanos C. Elala, Michael Hope, Matt Kaeberlein
Publikováno v:
Proceedings of the National Academy of Sciences. 116:3062-3071
Mutations accumulate within somatic cells and have been proposed to contribute to aging. It is unclear what level of mutation burden may be required to consistently reduce cellular lifespan. Human cancers driven by a mutator phenotype represent an in
Autor:
Ruofan Yu, Jun-yi Zhu, Wei Liu, Weiwei Dang, Brian M. Wasko, Haiying Liu, Lidong Qin, Luyang Sun, Zhe Han, Xiaohua Cao, Matt Kaeberlein, Emeline Crutcher, Myeong Chan Jo
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Histone acetylations are important epigenetic markers for transcriptional activation in response to metabolic changes and various stresses. Using the high-throughput SEquencing-Based Yeast replicative Lifespan screen method and the yeast knockout col
Autor:
Brian M Wasko, Daniel T Carr, Herman Tung, Ha Doan, Nathan Schurman, Jillian R Neault, Joey Feng, Janet Lee, Ben Zipkin, Jacob Mouser, Edward Oudanonh, Tina Nguyen, Torin Stetina, Anna Shemorry, Mekedes Lemma, Matt Kaeberlein
Publikováno v:
F1000Research, Vol 2 (2013)
During chronological aging of budding yeast cells, the culture medium can become acidified, and this acidification limits cell survival. As a consequence, buffering the culture medium to pH 6 significantly extends chronological life span under standa
Externí odkaz:
https://doaj.org/article/d509173d851b48a18df952effce209ff