Actin Crosslinking Family Protein 7 Deficiency Does Not Impair Hearing in Young Mice

Autor: Benjamin L. Gilbert, Shaoyuan Zhu, Ahlam Salameh, Shenyu Sun, Kumar N. Alagramam, Brian M. McDermott

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

To enable hearing, the sensory hair cell contains specialized subcellular structures at its apical region, including the actin-rich cuticular plate and circumferential band. ACF7 (actin crosslinking family protein 7), encoded by the gene Macf1 (micro

Externí odkaz: https://doaj.org/article/6a5a2745ec184a14a2b384f163625fbc

A molecular basis for water motion detection by the mechanosensory lateral line of zebrafish

Autor: Shih-Wei Chou, Zongwei Chen, Shaoyuan Zhu, Robin W. Davis, Jiaqi Hu, Li Liu, Carol A. Fernando, Kayla Kindig, William C. Brown, Ruben Stepanyan, Brian M. McDermott

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

In fish, water motion is detected by mechanosensitive hair cells located in the lateral line. Here the authors show that the molecular machinery for mechanotransduction, including transmembrane channel-like 2b (Tmc2b), varies depending on both hair c

Externí odkaz: https://doaj.org/article/4c25673ba954489aaa52619208964ab3

The Stereociliary Paracrystal Is a Dynamic Cytoskeletal Scaffold In Vivo

Autor: Philsang Hwang, Shih-Wei Chou, Zongwei Chen, Brian M. McDermott Jr.

Publikováno v: Cell Reports, Vol 13, Iss 7, Pp 1287-1294 (2015)

Permanency of mechanosensory stereocilia may be the consequence of low protein turnover or rapid protein renewal. Here, we devise a system, using optical techniques in live zebrafish, to distinguish between these mechanisms. We demonstrate that the s

Externí odkaz: https://doaj.org/article/0369a125beb04e1c84ab9efd75a2b860

ADAMTS1, MPDZ, MVD, and SEZ6:candidate genes for autosomal recessive nonsyndromic hearing impairment

Autor: Saima Riazuddin, Sakina Rehman, Liz M Nouel-Saied, Muhammad Ansar, Anushree Acharya, Shaoyuan Zhu, Lana M. Pollock, Ghazanfar Ali, Regie Lyn P. Santos-Cortez, Wasim Ahmad, Thashi Bharadwaj, Jenna L. Everard, Asmat Ullah, Khurram Liaqat, Michael J. Bamshad, Suzanne M. Leal, Isabelle Schrauwen, Brian M. McDermott, Raja Hussain Ali, Abdul Nasir, Abdul Wali, Arnaud P. J. Giese, Deborah A. Nickerson, Zubair M. Ahmed

Publikováno v: Bharadwaj, T, Schrauwen, I, Rehman, S, Liaqat, K, Acharya, A, Giese, A P J, Nouel-Saied, L M, Nasir, A, Everard, J L, Pollock, L M, Zhu, S, Bamshad, M J, Nickerson, D A, Ali, R H, Ullah, A, Wali, A, Ali, G, Santos-Cortez, R L P, Ahmed, Z M, McDermott, B M, Ansar, M, Riazuddin, S, Ahmad, W & Leal, S M 2022, ' ADAMTS1, MPDZ, MVD, and SEZ6 : candidate genes for autosomal recessive nonsyndromic hearing impairment ', European Journal of Human Genetics, vol. 30, pp. 22-33 . https://doi.org/10.1038/s41431-021-00913-x

Hearing impairment (HI) is a common disorder of sensorineural function with a highly heterogeneous genetic background. Although substantial progress has been made in the understanding of the genetic etiology of hereditary HI, many genes implicated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b3797ece0eb90be2e775eda90491d2
https://curis.ku.dk/ws/files/289458884/s41431_021_00913_x.pdf

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

Autor: Federico Gulluni, Lorenzo Prever, Huayi Li, Petra Krafcikova, Ilaria Corrado, Wen-Ting Lo, Jean Piero Margaria, Anlu Chen, Maria Chiara De Santis, Sophie J. Cnudde, Joseph Fogerty, Alex Yuan, Alberto Massarotti, Nasrin Torabi Sarijalo, Oscar Vadas, Roger L. Williams, Marcus Thelen, David R. Powell, Markus Schueler, Michael S. Wiesener, Tamas Balla, Hagit N. Baris, Dov Tiosano, Brian M. McDermott, Brian D. Perkins, Alessandra Ghigo, Miriam Martini, Volker Haucke, Evzen Boura, Giorgio Roberto Merlo, David A. Buchner, Emilio Hirsch

Publikováno v: Science

Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting complexes required for transport)-–dependent control of membrane remodeling at the midbody, a subcellular organelle that defines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b7b8e4bf586cb0f98e5fc0fb47473f
http://hdl.handle.net/2318/1831621