Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Brian M. McDermott"'
Autor:
Benjamin L. Gilbert, Shaoyuan Zhu, Ahlam Salameh, Shenyu Sun, Kumar N. Alagramam, Brian M. McDermott
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
To enable hearing, the sensory hair cell contains specialized subcellular structures at its apical region, including the actin-rich cuticular plate and circumferential band. ACF7 (actin crosslinking family protein 7), encoded by the gene Macf1 (micro
Externí odkaz:
https://doaj.org/article/6a5a2745ec184a14a2b384f163625fbc
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Hair cells are heterogenous, enabling varied roles in sensory systems. An emerging hypothesis is that the transmembrane channel-like (Tmc) proteins of the hair cell’s mechanotransduction apparatus vary within and between organs to permit encoding o
Externí odkaz:
https://doaj.org/article/93643b34144d45879d63b43d68c9270f
Autor:
Shih-Wei Chou, Zongwei Chen, Shaoyuan Zhu, Robin W. Davis, Jiaqi Hu, Li Liu, Carol A. Fernando, Kayla Kindig, William C. Brown, Ruben Stepanyan, Brian M. McDermott
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
In fish, water motion is detected by mechanosensitive hair cells located in the lateral line. Here the authors show that the molecular machinery for mechanotransduction, including transmembrane channel-like 2b (Tmc2b), varies depending on both hair c
Externí odkaz:
https://doaj.org/article/4c25673ba954489aaa52619208964ab3
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1287-1294 (2015)
Permanency of mechanosensory stereocilia may be the consequence of low protein turnover or rapid protein renewal. Here, we devise a system, using optical techniques in live zebrafish, to distinguish between these mechanisms. We demonstrate that the s
Externí odkaz:
https://doaj.org/article/0369a125beb04e1c84ab9efd75a2b860
Autor:
Jonathon W. Vargo, Steven N. Walker, Suhasini R. Gopal, Aditi R. Deshmukh, Brian M. McDermott Jr., Kumar N. Alagramam, Ruben Stepanyan
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Cisplatin and other related platinum antineoplastic drugs are commonly used in the treatment of a variety of cancers in both adults and children but are often associated with severe side effects, including hearing loss. Cisplatin’s ototoxic effects
Externí odkaz:
https://doaj.org/article/9b5dc028644e46ffa55a9e3205920ae4
Publikováno v:
Current Biology. 33:1295-1307.e3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5181f0664a78fcf4b721b94a211e2226
https://doi.org/10.1016/j.cub.2023.02.033
https://doi.org/10.1016/j.cub.2023.02.033
Autor:
Brian M. McDermott
Publikováno v:
Curr Biol
Animals have a remarkable ability to use local cues to orient in space in the absence of a panoramic fixed reference frame. Here we use the mechanosensory lateral line in larval zebrafish to understand rheotaxis, an innate oriented swimming evoked by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c058d1a6452725442b41821ec0ddc64c
https://pubmed.ncbi.nlm.nih.gov/33545047
https://pubmed.ncbi.nlm.nih.gov/33545047
Autor:
Federico Gulluni, Lorenzo Prever, Huayi Li, Petra Krafcikova, Ilaria Corrado, Wen-Ting Lo, Jean Piero Margaria, Anlu Chen, Maria Chiara De Santis, Sophie J. Cnudde, Joseph Fogerty, Alex Yuan, Alberto Massarotti, Nasrin Torabi Sarijalo, Oscar Vadas, Roger L. Williams, Marcus Thelen, David R. Powell, Markus Schueler, Michael S. Wiesener, Tamas Balla, Hagit N. Baris, Dov Tiosano, Brian M. McDermott, Brian D. Perkins, Alessandra Ghigo, Miriam Martini, Volker Haucke, Evzen Boura, Giorgio Roberto Merlo, David A. Buchner, Emilio Hirsch
Publikováno v:
Science
Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting complexes required for transport)-–dependent control of membrane remodeling at the midbody, a subcellular organelle that defines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b7b8e4bf586cb0f98e5fc0fb47473f
http://hdl.handle.net/2318/1831621
http://hdl.handle.net/2318/1831621
Autor:
Shih Wei Chou, Hannah Weaver, Ruben Stepanyan, Zongwei Chen, Brian M. McDermott, Robin Woods Davis, Shengxuan Wang, Kayla Kindig, Shaoyuan Zhu, Michael R Dercoli
Publikováno v:
Hum Mol Genet
Perception of sound is initiated by mechanically gated ion channels at the tips of stereocilia. Mature mammalian auditory hair cells require transmembrane channel-like 1 (TMC1) for mechanotransduction, and mutations of the cognate genetic sequences r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89566e925031035dfd01f49cf7128659
https://pubmed.ncbi.nlm.nih.gov/32167554
https://pubmed.ncbi.nlm.nih.gov/32167554
Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model
The pathogenic variant c.144T>G (p.N48K) in the clarin1 gene (CLRN1) results in progressive loss of vision and hearing in Usher syndrome IIIA (USH3A) patients. CLRN1 is predicted to be an essential protein in hair bundles, the mechanosensory structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70e1fbacaaf82ee4adaa5b2e656085b
https://europepmc.org/articles/PMC6561152/
https://europepmc.org/articles/PMC6561152/