Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brian M. Luna"'
Autor:
Travis B. Nielsen, Paul Pantapalangkoor, Jun Yan, Brian M. Luna, Ken Dekitani, Kevin Bruhn, Brandon Tan, Justin Junus, Robert A. Bonomo, Ann Marie Schmidt, Michael Everson, Frederick Duncanson, Terence M. Doherty, Lin Lin, Brad Spellberg
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT For more than a century, diabetic patients have been considered immunosuppressed due to defects in phagocytosis and microbial killing. We confirmed that diabetic mice were hypersusceptible to bacteremia caused by Gram-negative bacteria (GNB)
Externí odkaz:
https://doaj.org/article/3a117f40f0ff46a9bfb007c3c903625c
Autor:
Brian M. Luna, Amber Ulhaq, Jun Yan, Paul Pantapalangkoor, Travis B. Nielsen, Bryan W. Davies, Luis A. Actis, Brad Spellberg
Publikováno v:
mSphere, Vol 2, Iss 2 (2017)
ABSTRACT Acinetobacter baumannii is one of the most antibiotic-resistant pathogens in clinical medicine, and extensively drug-resistant (XDR) strains are commonly isolated from infected patients. Such XDR strains are already resistant to traditional
Externí odkaz:
https://doaj.org/article/83a4f617d2854795966090823a1b017a
Autor:
Travis B Nielsen, Jun Yan, Matthew Slarve, Rachel Li, Jason A Junge, Brian M Luna, Ian Wilkinson, Udaya Yerramalla, Brad Spellberg
Publikováno v:
The Journal of Infectious Diseases. 227:1042-1049
Background We previously reported developing 2 anticapsular monoclonal antibodies (mAbs) as a novel therapy for Acinetobacter baumannii infections. We sought to determine whether a bispecific mAb (bsAb) could improve avidity and efficacy while maximi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0220a7f98b2e880dcd1fbcf2fb5baf
https://doi.org/10.1093/infdis/jiac499
https://doi.org/10.1093/infdis/jiac499
Autor:
Yuanyuan Jiao, Jun Yan, Michael Vicchiarelli, Dhruvitkumar S. Sutaria, Peggy Lu, Zeferino Reyna, Brad Spellberg, Robert A. Bonomo, George L. Drusano, Arnold Louie, Brian M. Luna, Jürgen B. Bulitta
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Polymyxin B is a “last-line-of-defense” antibiotic approved in the 1960s. However, the population pharmacokinetics (PK) of its four main components has not been reported in infected mice. We aimed to determine the PK of polymyxin B1, B1-Ile, B2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5feafbde13c8452ba67ec43eda832726
https://doi.org/10.1128/aac.00197-23
https://doi.org/10.1128/aac.00197-23
Introduction: Human pathogens have experienced selective pressure from antibiotics for nearly 80 years. The high speed of antibiotic resistance formation in nosocomial bacteria together with overuse of antibiotics has promoted the current multidrug r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460b9f13932e111dd9e225e60eb7b69e
Autor:
Brian M Luna, Jun Yan, Zeferino Reyna, Eugene Moon, Travis B Nielsen, Hernan Reza, Peggy Lu, Robert Bonomo, Arnold Louie, George Drusano, Jürgen Bulitta, Rosemary She, Brad Spellberg
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219824 (2019)
In 2017, the WHO identified Acinetobacter baumannii as the top priority for the development of new antibiotics. Despite the need for new antibiotics, there remains a lack of well validated preclinical tools for A. baumannii. Here, we characterize and
Externí odkaz:
https://doaj.org/article/bc06e2509ee34e9294fd5e940445f5a3
Autor:
Brian M Luna, Travis B Nielsen, Brian Cheng, Paul Pantapalangkoor, Jun Yan, Susan Boyle-Vavra, Kevin W Bruhn, Christopher Montgomery, Brad Spellberg, Robert Daum
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217439 (2019)
Staphylococcus aureus infections represent a major public health threat, but previous attempts at developing a universal vaccine have been unsuccessful. We attempted to identify a vaccine that would be protective against both skin/soft tissue and blo
Externí odkaz:
https://doaj.org/article/ad74e8c6942b446092e38f3a1880aa19