Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Brian M. Lamb"'
1
A semisynthetic organism engineered for the stable expansion of the genetic alphabet
Autor: Zhou Anne Xiaozhou, Brian M. Lamb, Thomas Lavergne, Floyd E. Romesberg, Aaron W. Feldman, Yorke Zhang, Lingjun Li
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (6), pp.1317-1322. ⟨10.1073/pnas.1616443114⟩
All natural organisms store genetic information in a four-letter, two-base-pair genetic alphabet. The expansion of the genetic alphabet with two synthetic unnatural nucleotides that selectively pair to form an unnatural base pair (UBP) would increase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241bdbc4a27a8b698d3320a583cb9de6
https://hal.archives-ouvertes.fr/hal-01636967
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2
Regulation of Endogenous Human Gene Expression by Ligand-Inducible TALE Transcription Factors
Autor: Shannon J. Sirk, Carlos F. Barbas, Brian M. Lamb, Thomas Gaj, Andrew C. Mercer
Publikováno v: ACS Synthetic Biology
The construction of increasingly sophisticated synthetic biological circuits is dependent on the development of extensible tools capable of providing specific control of gene expression in eukaryotic cells. Here, we describe a new class of synthetic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f926dd01893a8e247c83882f21020bbd
http://europepmc.org/articles/PMC4097969
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3
Microfluidic Permeation Printing of Self-Assembled Monolayer Gradients on Surfaces for Chemoselective Ligand Immobilization Applied to Cell Adhesion and Polarization
Autor: Brian M. Lamb, Muhammad N. Yousaf, Sungjin Park
Publikováno v: Langmuir. 26:12817-12823
To study complex cell behavior on model surfaces requires biospecific interactions between the interfacing cell and material. Developing strategies to pattern well-defined molecular gradients on surfaces is difficult but critical for studying cell ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e454ae8d2d85f474a3ef2b5ac3921b15
https://doi.org/10.1021/la1022642
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5
Electrochemical and Chemical Microfluidic Gold Etching to Generate Patterned and Gradient Substrates for Cell Adhesion and Cell Migration
Autor: Brian M. Lamb, Muhammad N. Yousaf, Nathan P. Westcott
Publikováno v: Analytical Chemistry. 81:3297-3303
To generate patterned substrates of self-assembled monolayers (SAMs) for cell adhesion and migration studies, a variety of gold/glass hybrid substrates were fabricated from gold evaporated on glass. A variety of surfaces were generated including grad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981be1f43a048fbd4a7f3cb6dbd12af9
https://doi.org/10.1021/ac802509y
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6
Selective arylthiolane deprotection by singlet oxygen: a promising tool for sensors and prodrugs
Autor: Brian M. Lamb, Carlos F. Barbas
Publikováno v: Chemical communications (Cambridge, England). 51(15)
A routine thioketal protecting group reacts rapidly and selectively with singlet oxygen to reveal ketone products in good (aryl 1,3-dithiolane) to excellent (aryl 1,3-oxathiolane) yields. Arylthiolanes are stable to biologically relevant reactive oxy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a323d872dbb47c3615ea098e34903e
https://pubmed.ncbi.nlm.nih.gov/25604598
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7
Remote Control of Tissue Interactions via Engineered Photo-switchable Cell Surfaces
Autor: Muhammad N. Yousaf, Abigail Pulsipher, Brian M. Lamb, Wei Luo, Debjit Dutta
Publikováno v: Scientific Reports
We report a general cell surface molecular engineering strategy via liposome fusion delivery to create a dual photo-active and bio-orthogonal cell surface for remote controlled spatial and temporal manipulation of microtissue assembly and disassembly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01dbf1d573d516396db25e471219ce6
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8
Cell division orientation on biospecific peptide gradients
Autor: Brian M. Lamb, Muhammad N. Yousaf, Sarbajeet Nagdas, Wei Luo
Publikováno v: ACS applied materialsinterfaces. 6(14)
An assay was developed for determining cell division orientation on gradients. The methodology is based on permeating microfluidic devices with alkanethiols and subsequent printing of cell adhesive peptide gradient self-assembled monolayers (SAMs) fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eefa30a6cfe5f2815f2c3c40d4e2bfe
https://pubmed.ncbi.nlm.nih.gov/25007410
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10
Redox-switchable surface for controlling peptide structure
Autor: Brian M. Lamb, Muhammad N. Yousaf
Publikováno v: Journal of the American Chemical Society. 133(23)
A general surface chemistry strategy is described for the development of a new switchable material. The method modulates a surface-immobilized-molecules structure by using two orthogonal “click” reactions based on Huisgen cycloaddition and oxime
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e8feb42be2bb35e189ee4905adc913
https://pubmed.ncbi.nlm.nih.gov/21595476
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