Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Brian M. Jekich"'
Publikováno v:
Wilderness & Environmental Medicine. 28:382-383
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9fca7f8e7f12e5e2152c09c6643c69
https://doi.org/10.1016/j.wem.2017.09.006
https://doi.org/10.1016/j.wem.2017.09.006
Autor:
Brian M. Jekich, Ray Chavez, Evan M. Sloane, Dennis Klinman, Garth Huberty, Steven F. Maier, Leslie A. Leinwand, Benjamen D. Coats, Jackie Harrison, John H. Mahoney, Whitney Seibert, Travis S. Hughes, Matthew G. Frank, Linda R. Watkins, Kirk W. Johnson, Erin D. Milligan, S. Langer, Steven Poole
Publikováno v:
Gene therapy
Summary We recently described a non-viral gene therapy paradigm offering long-term resolution of established neuropathic pain in several animal models. Here, the requirements for long term therapeutic effects are described, and evidence is provided f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1397c51d111b744c1af1ed3371a0c923
http://europepmc.org/articles/PMC2762489
http://europepmc.org/articles/PMC2762489
Autor:
Niloofar Rezvani, Brian M. Jekich, Susannah S. Lewis, Linda R. Watkins, David Martin, Andrew A. Somogyi, Charles M. Judd, Benjamen D. Coats, David Sprunger, Steven F. Maier, Stephen Poole, Eric M. Baker, Julie Wieseler, Mark R. Hutchinson, Yingning Zhang
Publikováno v:
Brain, Behavior, and Immunity. 22:1178-1189
Spinal proinflammatory cytokines are powerful pain-enhancing signals that contribute to pain following peripheral nerve injury (neuropathic pain). Recently, one proinflammatory cytokine, interleukin-1, was also implicated in the loss of analgesia upo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e50f6ae5083c04e41c4617491e3edb5
https://doi.org/10.1016/j.bbi.2008.05.004
https://doi.org/10.1016/j.bbi.2008.05.004
Autor:
Erin D. Milligan, Stephen J. Langer, Leslie A. Leinwand, David Martin, Evan M. Sloane, Kirk W. Johnson, Brian M. Jekich, Raymond A. Chavez, Linda R. Watkins, Steven F. Maier, John H. Mahoney, Annemarie Ledeboer
Publikováno v:
Brain, Behavior, and Immunity. 21:686-698
Paclitaxel is a commonly used cancer chemotherapy drug that frequently causes painful peripheral neuropathies. The mechanisms underlying this dose-limiting side effect are poorly understood. Growing evidence supports that proinflammatory cytokines, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45673d95cc76ec638d5d6b752d703ea
https://doi.org/10.1016/j.bbi.2006.10.012
https://doi.org/10.1016/j.bbi.2006.10.012
Publikováno v:
Wildernessenvironmental medicine. 27(1)
To describe demographic patterns in avalanche fatalities in the United States during the past 6 decades according to geographic location and preavalanche activity.The Colorado Avalanche Information Center currently manages the National Avalanche Acci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17cb8cf481390948e67675a62a9e158
https://pubmed.ncbi.nlm.nih.gov/29097065
https://pubmed.ncbi.nlm.nih.gov/29097065
Autor:
John H. Mahoney, Matthew G. Frank, Steven F. Maier, Evan M. Sloane, Terence R. Flotte, Kirk W. Johnson, Melissa M. Mahoney, Raymond A. Chavez, Lindsay H. Levkoff, Leslie A. Leinwand, Linda R. Watkins, Travis S. Hughes, Pedro E. Cruz, Erin D. Milligan, Stephen J. Langer, Brian M. Jekich
Publikováno v:
Pain. 126:294-308
Neuropathic pain is a major clinical problem unresolved by available therapeutics. Spinal cord glia play a pivotal role in neuropathic pain, via the release of proinflammatory cytokines. Anti-inflammatory cytokines, like interleukin-10 (IL-10), suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2561eedcf0930a12a8beb6a55a9dc54
https://doi.org/10.1016/j.pain.2006.07.009
https://doi.org/10.1016/j.pain.2006.07.009
Autor:
Steven F. Maier, Brian M. Jekich, Sondra T. Bland, Linda R. Watkins, Julie Wieseler-Frank, John H. Mahoney
Publikováno v:
Brain, behavior, and immunity. 21(5)
Pain is enhanced in response to elevations of proinflammatory cytokines in spinal cerebrospinal fluid (CSF), following either intrathecal injection of these cytokines or intrathecal immune challenge with HIV-1 gp120 that induces cytokine release. Spi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900f2674592b444655ac92c7deefdc14
https://pubmed.ncbi.nlm.nih.gov/16989980
https://pubmed.ncbi.nlm.nih.gov/16989980
Autor:
Julie Wieseler-Frank, Evan M. Sloane, Ruth M. Barrientos, Steven F. Maier, Linda R. Watkins, D. Schoeniger, Erin D. Milligan, Leah E. Spataro, Brian M. Jekich
Publikováno v:
The journal of pain. 5(7)
Glia are now recognized as important contributors in pathological pain creation and maintenance. Spinal cord glia exhibit extensive gap junctional connectivity, raising the possibility that glia are involved in the contralateral spread of excitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43cc55cedb1f4d0e0835a2129ba29020
https://pubmed.ncbi.nlm.nih.gov/15501197
https://pubmed.ncbi.nlm.nih.gov/15501197
Autor:
John H. Mahoney, Kirk W. Johnson, Raymond A. Chavez, Evan M. Sloane, S.F. Maier, Terence R. Flotte, Leslie A. Leinwand, Brian M. Jekich, Travis S. Hughes, Pedro E. Cruz, Linda R. Watkins, Melissa J. Mahoney, Erin D. Milligan, Stephen J. Langer
Publikováno v:
Molecular Therapy. 11:S249-S250
Chronic pain control is a major unresolved clinical problem. Spinal cord astrocytes & microglia are critically involved in the creation & maintenance of diverse enhanced pain states via the release of proinflammatory cytokines. Interleukin-10 (IL-10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c94819289b0a2687712951ebdb3c44e0
https://doi.org/10.1016/j.ymthe.2005.07.184
https://doi.org/10.1016/j.ymthe.2005.07.184
Autor:
Evan M. Sloane, Brian M. Jekich, Kirk W. Johnson, Raymond A. Chavez, Erin D. Milligan, Annemarie Ledeboer, Stephen J. Langer, Leslie A. Leinwand, Steven F. Maier, Linda R. Watkins, John H. Mahoney
Publikováno v:
Brain, Behavior, and Immunity. 20:43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb500829db6fb8bf26eecf1b3d79d20c
https://doi.org/10.1016/j.bbi.2006.04.082
https://doi.org/10.1016/j.bbi.2006.04.082