Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Brian M. Janelsins"'
Autor:
Jim McNally, Szilárd Kamondi, Daniel Kramer, Honglue Shen, Vibha Jawa, Jane Ruppel, Charles S Hottenstein, Kelli R. Phillips, Meina Liang, Michael E Hodsdon, Dong Geng, Joanne Goodman, Mohsen Rajabi Ahbari, Heather Myler, Marta Starcevic Manning, Alvydas Mikulskis, William Hallett, Haoheng Yan, Adrienne Clements-Egan, Paul Chamberlain, Qiang Qu, ZhenZhen Liu, Carol Gleason, Viswanath Devanaryan, George R Gunn, Susan M. Richards, Theresa J Goletz, Troy E. Barger, Susana Liu, Lakshmi Amaravadi, Veerle Snoeck, Joao Pedras-Vasconcelos, Kathryn Lindley, Robert Nelson, Mark Ware, Shobha Purushothama, An Song, Susan Kirshner, Brian M Janelsins, Jad Zoghbi, Steven Bowen, Ronald R. Bowsher
Publikováno v:
The AAPS Journal. 24
Evolving immunogenicity assay performance expectations and a lack of harmonized anti-drug antibody validation testing and reporting tools have resulted in significant time spent by health authorities and sponsors on resolving filing queries. Followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bacf181ab0fa77b1607ce8395bb2e0
https://doi.org/10.1208/s12248-021-00649-y
https://doi.org/10.1208/s12248-021-00649-y
Publikováno v:
Proceedings of the National Academy of Sciences. 111:373-378
Interleukin (IL) 17-secreting CD4(+) helper T cells (Th17 cells) are essential for host defense at mucosal surfaces, and Th17 cell dysregulation can result in autoimmunity. Exposure to microbial products, such as bacterial LPS, can affect the ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa111dab4429e1da232eedf4201a2001
https://doi.org/10.1073/pnas.1311987111
https://doi.org/10.1073/pnas.1311987111
Autor:
Sandip K. Datta, Paul J. Vithayathil, Ian A. Myles, Brian M. Janelsins, Natalia M. Fontecilla, Julia A. Segre
Publikováno v:
The Journal of Immunology. 191:3200-3209
Mechanisms underlying modern increases in prevalence of human inflammatory diseases remain unclear. The hygiene hypothesis postulates that decreased microbial exposure has, in part, driven this immune dysregulation. However, dietary fatty acids also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f94a1c0b423dec07c008950f8ed72c35
https://doi.org/10.4049/jimmunol.1301057
https://doi.org/10.4049/jimmunol.1301057
Autor:
Patricia A. Valdez, Arthur L. Shaffer, Paul J. Vithayathil, Sandip K. Datta, Brian M. Janelsins, Peter R. Williamson
Publikováno v:
Immunity. 36(4):668-679
SummaryT helper 17 (Th17) cells play an important role in mucosal host defense through production of the signature cytokines IL-17 and IL-22. Prostaglandin E2 (PGE2) has been shown to enhance IL-17 production by mature Th17 cells. However, when prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667305c32f9c5a8651bbc30feb9eb078
Autor:
Sandip K. Datta, Miriam R. Anver, Scott K. Durum, Julie A. Hixon, Miranda L. Hanson, Wei Shen, Wenqing Li, Mairi H. McLean, Barbara K. Felber, Brian M. Janelsins, C. Andrew Stewart
Background & Aims Treatment of inflammatory bowel disease would benefit from specific targeting of therapeutics to the intestine. We developed a strategy for localized delivery of the immunosuppressive cytokine interleukin (IL)-27, which is synthesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0f8fe5d9cc829025985b3b8ff37d72
https://europepmc.org/articles/PMC3920828/
https://europepmc.org/articles/PMC3920828/
Autor:
Darling M. Rojas-Canales, Adriana T. Larregina, William J. Shufesky, Geza Erdos, Alicia R. Mathers, Walter J. Storkus, Olga A. Tkacheva, Adrian E. Morelli, Brian M. Janelsins, Tina L. Sumpter, Louis D. Falo
Substance-P and hemokinin-1 are proinflammatory neuropeptides with potential to promote type 1 immunity through agonistic binding to neurokinin-1 receptor (NK1R). Dendritic cells (DCs) are professional antigen-presenting cells that initiate and regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d9233e2253d6e04866d6d00f8c20a3
https://europepmc.org/articles/PMC3624938/
https://europepmc.org/articles/PMC3624938/
Autor:
Adrian E. Morelli, Simon C. Watkins, Brian M. Janelsins, Olga A. Tkacheva, Joseph P Rubin, William J. Shufesky, Alicia R. Mathers, Adriana T. Larregina
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 182(2)
Human skin-migratory dendritic cells (DCs) have the ability to prime and bias Th1 and Th2 CD4+ T lymphocytes. However, whether human cutaneous DCs are capable of initiating proinflammatory Th17 responses remains undetermined. We report that skin-migr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfb6efaa96370843985aedb5ad7a3ed
https://pubmed.ncbi.nlm.nih.gov/19124735
https://pubmed.ncbi.nlm.nih.gov/19124735
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1213ad39055be13a4dc9f7594b7d3a67
https://doi.org/10.1096/fasebj.22.1_supplement.1065.15
https://doi.org/10.1096/fasebj.22.1_supplement.1065.15
Autor:
Alicia R. Mathers, Olga A. Tkacheva, Adriana T. Larregina, Joseph P Rubin, Brian M. Janelsins
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c3512e7b337b3f1218f69cc945d4c03
https://doi.org/10.1096/fasebj.22.1_supplement.846.26
https://doi.org/10.1096/fasebj.22.1_supplement.846.26
Autor:
Adrian E. Morelli, Olga A. Tckacheva, William J. Shufesky, Adriana T. Larregina, Brian M. Janelsins, Alicia R. Mathers
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(11)
The proinflammatory capacities of the skin and the presence of high numbers of resident dendritic cells (DCs) constitute an ideal microenvironment for successful immunizations. Regardless of the ability of DCs to respond to local inflammatory signals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fef14a34427d724a6bce3c1a397b313
https://pubmed.ncbi.nlm.nih.gov/17513750
https://pubmed.ncbi.nlm.nih.gov/17513750