Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Brian M. J., Foxwell"'
Autor:
J Brian de Souza, Uduak Okomo, Neal D Alexander, Naveed Aziz, Benjamin M J Owens, Harparkash Kaur, Momodou Jasseh, Sant Muangnoicharoen, Percy F Sumariwalla, David C Warhurst, Stephen A Ward, David J Conway, Luis Ulloa, Kevin J Tracey, Brian M J Foxwell, Paul M Kaye, Michael Walther
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9867 (2010)
Safe, cheap and effective adjunct therapies preventing the development of, or reducing the mortality from, severe malaria could have considerable and rapid public health impact. Oral activated charcoal (oAC) is a safe and well tolerated treatment for
Externí odkaz:
https://doaj.org/article/9aec678a30cc4eeeaaa65f992719810f
Autor:
Andrew P. Cope, A M Kissonerghis, K Barrett, Marc Feldmann, P W Gray, Brian M. J. Foxwell, David A. Taylor-Fishwick
Publikováno v:
Scopus-Elsevier
Tumor necrosis factor (TNF) mediates its pleiotropic effects via high-affinity cell surface receptors. In man, molecular cloning has identified two distinct, independent TNF receptors (TNFR) of 55 and 75 kDa. It is unclear, however, whether the multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5190c20a19073ab08584f999729976
https://ora.ox.ac.uk/objects/uuid:aee57b19-39f1-423c-b866-143aed4ce36a
https://ora.ox.ac.uk/objects/uuid:aee57b19-39f1-423c-b866-143aed4ce36a
Autor:
Irina A. Udalova, Jamie Campbell, Clive Smith, Agnes Denys, Lynn M. Williams, Dominic Kwaitkowski, Caroline Andrews, Cathleen J. Ciesielski, Brian M. J. Foxwell
IL-10 is a potent anti-inflammatory cytokine and inhibitor of TNF-α production. The molecular pathways by which IL-10 inhibits TNF-α production are obscure, with diverse mechanisms having been published. In this study, a new approach has been taken
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cee0b6d3e39fb14817bddcc32ba6475
https://ora.ox.ac.uk/objects/uuid:d594aa5a-b2e4-4d47-a019-ecce17f6394f
https://ora.ox.ac.uk/objects/uuid:d594aa5a-b2e4-4d47-a019-ecce17f6394f
Autor:
Marc Feldmann, Sandra Sacre, Evangelos Andreakos, Corinne Taylor, Brian M. J. Foxwell, Anna M. Lundberg
TLR signal via Toll-IL-1R (TIR) homology domain-containing adaptor proteins. One of these adaptors, Toll-IL-1R domain-containing adaptor inducing IFN-β-related adaptor molecule (TRAM), has been shown to be essential for TLR4 signaling in TRAM−/−
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468ff172aae47f6b2edbefdc35ddcd2e
https://doi.org/10.4049/jimmunol.178.4.2148
https://doi.org/10.4049/jimmunol.178.4.2148
Autor:
Stefan K. Drexler, Gertraud Orend, Masahide Kashiwagi, Brian M. J. Foxwell, Nidhi Sofat, Kim S. Midwood, Anna M. Piccinini, Fionula M. Brennan, Annette Trebaul, Julia J. Inglis, Sandra Sacre, Emma Chan
Although there have been major advances in the treatment of rheumatoid arthritis with the advent of biological agents, the mechanisms that drive cytokine production and sustain disease chronicity remain unknown. Tenascin-C (encoded by Tnc) is an extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48423056d64128ee92e3cbde0848d11
https://ora.ox.ac.uk/objects/uuid:ebf9d5c3-59db-45a1-bb51-3977370733e4
https://ora.ox.ac.uk/objects/uuid:ebf9d5c3-59db-45a1-bb51-3977370733e4
Autor:
Clive Smith, Brian M. J. Foxwell, Marc Feldmann, Fionula M. Brennan, Claudia Monaco, Evangelos Andreakos
Although dendritic cells (DCs) are the most potent antigen-presenting cells involved in numerous physiologic and pathologic processes, little is known about the signaling pathways that regulate DC activation and antigen-presenting function. Recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566dd2172522578c6317de97dd23082e
https://ora.ox.ac.uk/objects/uuid:b1ba6f4e-25f3-4fc8-8053-7b68bfb23c0c
https://ora.ox.ac.uk/objects/uuid:b1ba6f4e-25f3-4fc8-8053-7b68bfb23c0c
Autor:
David Wallach, Deena L. Gibbons, Brian M. J. Foxwell, Fionula M. Brennan, Andrew P. Cope, Dan Aderka, Marc Feldmann, Ravinder N. Maini
Interleukin 4 (IL-4) has previously been shown to downregulate the production of proinflammatory cytokines such as TNF-alpha, and hence has been considered to be a potential anti-inflammatory agent. In this study we have investigated the effects of I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52efd577c9600ad0e3c08ff97b95dd91
https://ora.ox.ac.uk/objects/uuid:0fd7b8b0-38cc-4aa3-89e8-e0d787ba8e1f
https://ora.ox.ac.uk/objects/uuid:0fd7b8b0-38cc-4aa3-89e8-e0d787ba8e1f
Antigen presentation is a key rate-limiting step in the immune response. Dendritic cells (DCs) have been reported to be the most potent antigen-presenting cells for naïve T cells, but little is known about the biochemical pathways that regulate this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded397e4711133b563437ab3dbde2942
https://doi.org/10.1046/j.1365-3083.2003.01246.x
https://doi.org/10.1046/j.1365-3083.2003.01246.x
We demonstrate that interleukin-10 (IL-10) can inhibit T-cell apoptosis. T cells, within a PBMC (peripheral blood mononuclear cell) population, were stimulated via the T-cell receptor and grown in the presence of IL-2. These cells had less apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f6646b0af693e004632f1f717ced81
https://doi.org/10.1046/j.1365-2567.1997.00348.x
https://doi.org/10.1046/j.1365-2567.1997.00348.x
Publikováno v:
Proceedings of the National Academy of Sciences. 107:20518-20522
Cognitive decline following surgery in older individuals is a major clinical problem of uncertain mechanism; a similar cognitive decline also follows severe infection, chemotherapy, or trauma and is currently without effective therapy. A variety of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46efcf781f1423dce1803f0ba431c519
https://doi.org/10.1073/pnas.1014557107
https://doi.org/10.1073/pnas.1014557107