Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Brian M. Gulledge"'
Autor:
Bo Liang, Adam D. Richardson, James J. La Clair, Thomas P. Brady, Matthew D Alexander, Joel S. Sandler, Santosh J. Gharpure, Alexei Polosukhin, Hai Ren Zhang, Xiaobin Ding, Madeleine M. Joullié, A. Richard Chamberlin, Chris M. Ireland, James B. Aggen, Brian M. Gulledge, Mary Kay Harper, Michael D. Burkart, P. Andrew Evans, Binh G. Vong, William Fenical, Padma Portonovo, Emmanuel A. Theodorakis, Michael S. Leonard, Jian Cui
Publikováno v:
Chembiochem : a European journal of chemical biology. 7(3)
A Central Strategy for Converting Natural Products into Fluorescent Probes Matthew D. Alexander, Michael D. Burkart, Michael S. Leonard, Padma Portonovo, Bo Liang, Xiaobin Ding, Madeleine M. Joulli!, Brian M. Gulledge, James B. Aggen, A. Richard Cham
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(17)
A series of greatly simplified microcystin analogues comprised only of Adda (the beta-amino acid common to the microcystins, nodularins, and motuporin,) and a single additional amino acid residue was synthesized and screened for inhibition of the pro
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(17)
A series of acyclic, truncated microcystin analogues, comprised of the dienic beta-amino acid (Adda) and up to four additional amino acids characteristic of the parent toxin, was synthesized and screened for activity as inhibitors of PP1 and PP2A. De
Publikováno v:
Current medicinal chemistry. 9(22)
The serine/threonine phosphatases are inhibited by a variety of natural toxins, including the microcystins and nodularins. Progress in understanding the details of the biosynthetic origin and the binding of these compounds is discussed, as is the pro
Autor:
A. Richard Chamberlin, James J. La Clair, Brian M. Gulledge, Joel S. Sandler, William Fenical
Publikováno v:
Journal of the American Chemical Society. 127:9320-9321
The identification of natural product producer organisms remains a problem for both isolation and natural product classification. A concise screen is developed through fluorescent modification of a set of natural products that offer a common activity