Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Brian M Polster"'
Autor:
Rebecca V Walker, Qin Yao, Hangxue Xu, Anthony Maranto, Kristen F Swaney, Sreekumar Ramachandran, Rong Li, Laura Cassina, Brian M Polster, Patricia Outeda, Alessandra Boletta, Terry Watnick, Feng Qian
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Fibrocystin/Polyductin (FPC), encoded by PKHD1, is associated with autosomal recessive polycystic kidney disease (ARPKD), yet its precise role in cystogenesis remains unclear. Here we show that FPC undergoes complex proteolytic processing in
Externí odkaz:
https://doaj.org/article/51cef6557ba141899a2c0bf5768dce69
Autor:
Guus M Bol, Farhad Vesuna, Min Xie, Jing Zeng, Khaled Aziz, Nishant Gandhi, Anne Levine, Ashley Irving, Dorian Korz, Saritha Tantravedi, Marise R Heerma van Voss, Kathleen Gabrielson, Evan A Bordt, Brian M Polster, Leslie Cope, Petra van derGroep, Atul Kondaskar, Michelle A Rudek, Ramachandra S Hosmane, Elsken van derWall, Paul J vanDiest, Phuoc T Tran, Venu Raman
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 5, Pp 648-669 (2015)
Abstract Lung cancer is the most common malignancy worldwide and is a focus for developing targeted therapies due to its refractory nature to current treatment. We identified a RNA helicase, DDX3, which is overexpressed in many cancer types including
Externí odkaz:
https://doaj.org/article/e07c631e5fec4cceaa092c7b616dd2dc
Autor:
Pascaline Clerc, Christina A Young, Evan A Bordt, Alina M Grigore, Gary Fiskum, Brian M Polster
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79982 (2013)
Extracellular glutamate is elevated following brain ischemia or trauma and contributes to neuronal injury. We tested the hypothesis that magnesium sulfate (MgSO4, 3 mM) protects against metabolic failure caused by excitotoxic glutamate exposure. Rat
Externí odkaz:
https://doaj.org/article/942bf401d18342409a0a74771661ef05
Autor:
Pascaline Clerc, Brian M Polster
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34465 (2012)
Mitochondrial dysfunction is a component of many neurodegenerative conditions. Measurement of oxygen consumption from intact neurons enables evaluation of mitochondrial bioenergetics under conditions that are more physiologically realistic compared t
Externí odkaz:
https://doaj.org/article/4200546df923460fa7ab156230edb2c1
Autor:
Pascaline Clerc, Gregory B Carey, Zara Mehrabian, Michael Wei, Hyehyun Hwang, Geoffrey D Girnun, Hegang Chen, Stuart S Martin, Brian M Polster
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42487 (2012)
Cells that exhibit an absolute dependence on the anti-apoptotic BCL-2 protein for survival are termed "primed for death" and are killed by the BCL-2 antagonist ABT-737. Many cancers exhibit a primed phenotype, including some that are resistant to con
Externí odkaz:
https://doaj.org/article/95fe4f0ba4dd4279922482fe92357744
Autor:
Ramzi J Khairallah, Junhwan Kim, Karen M O'Shea, Kelly A O'Connell, Bethany H Brown, Tatiana Galvao, Caroline Daneault, Christine Des Rosiers, Brian M Polster, Charles L Hoppel, William C Stanley
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34402 (2012)
Mitochondria can depolarize and trigger cell death through the opening of the mitochondrial permeability transition pore (MPTP). We recently showed that an increase in the long chain n3 polyunsaturated fatty acids (PUFA) docosahexaenoic acid (DHA; 22
Externí odkaz:
https://doaj.org/article/1fe31664e72946438d1b8563049d6a60
Autor:
Sourabh Samaddar, Anya J O'Neal, Liron Marnin, Agustin Rolandelli, Nisha Singh, Xiaowei Wang, L. Rainer Butler, Parisa Rangghran, Hanna J Laukaitis, Francy E Cabrera Paz, Gary M Fiskum, Brian M Polster, Joao HF Pedra
Publikováno v:
bioRxiv
Arthropod-borne microbes rely on the metabolic state of a host to cycle between evolutionarily distant species. For instance, arthropod tolerance to infection may be due to redistribution of metabolic resources, often leading to microbial transmissio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dadefc7989a13d65b3ac4e6e59c20d7
https://doi.org/10.1101/2023.05.26.542501
https://doi.org/10.1101/2023.05.26.542501
Autor:
Maureen A. Kane, Weiliang Huang, Lin Zou, W. Jonathan Lederer, Nagendra Yadava, Jing Zhu, Wei Chao, Yang Yang, Fengqian Chen, Liron Boyman, Briana K. Shimada, Brian M. Polster
Publikováno v:
Shock. 57:553-564
BACKGROUND Sepsis-induced cardiomyopathy (SIC) is a major contributing factor for morbidity and mortality in sepsis. Accumulative evidence has suggested that cardiac mitochondrial oxidative phosphorylation is attenuated in sepsis, but the underlying
Publikováno v:
Biomolecules; Volume 12; Issue 7; Pages: 1004
Glutamate excitotoxicity contributes to many neurodegenerative diseases. Excessive glutamate receptor-mediated calcium entry causes delayed calcium deregulation (DCD) that coincides with abrupt mitochondrial depolarization. We developed cA-TAT, a liv
Publikováno v:
Molecular carcinogenesis. 61(9)
Primary tumors evolve metabolic mechanisms favoring glycolysis for adenosine triphosphate (ATP) generation and antioxidant defenses. In contrast, metastatic cells frequently depend on mitochondrial respiration and oxidative phosphorylation (OxPhos).