Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Brian M McDermott"'
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158349 (2016)
The organ of Corti has evolved a panoply of cells with extraordinary morphological specializations to harness, direct, and transduce mechanical energy into electrical signals. Among the cells with prominent apical specializations are hair cells and n
Externí odkaz:
https://doaj.org/article/fea6ed4bc76e4ec492ad78ef613f0dc0
Autor:
Shih-Wei Chou, Philsang Hwang, Gustavo Gomez, Carol A Fernando, Megan C West, Lana M Pollock, Jennifer Lin-Jones, Beth Burnside, Brian M McDermott
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e14807 (2011)
Stereocilia are actin-filled protrusions that permit mechanotransduction in the internal ear. To identify proteins that organize the cytoskeleton of stereocilia, we scrutinized the hair-cell transcriptome of zebrafish. One promising candidate encodes
Externí odkaz:
https://doaj.org/article/499b9417dd124ad383fe836cee125988
Autor:
Benjamin L. Gilbert, Shaoyuan Zhu, Ahlam Salameh, Shenyu Sun, Kumar N. Alagramam, Brian M. McDermott
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
To enable hearing, the sensory hair cell contains specialized subcellular structures at its apical region, including the actin-rich cuticular plate and circumferential band. ACF7 (actin crosslinking family protein 7), encoded by the gene Macf1 (micro
Externí odkaz:
https://doaj.org/article/6a5a2745ec184a14a2b384f163625fbc
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Hair cells are heterogenous, enabling varied roles in sensory systems. An emerging hypothesis is that the transmembrane channel-like (Tmc) proteins of the hair cell’s mechanotransduction apparatus vary within and between organs to permit encoding o
Externí odkaz:
https://doaj.org/article/93643b34144d45879d63b43d68c9270f
Autor:
Shih-Wei Chou, Zongwei Chen, Shaoyuan Zhu, Robin W. Davis, Jiaqi Hu, Li Liu, Carol A. Fernando, Kayla Kindig, William C. Brown, Ruben Stepanyan, Brian M. McDermott
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
In fish, water motion is detected by mechanosensitive hair cells located in the lateral line. Here the authors show that the molecular machinery for mechanotransduction, including transmembrane channel-like 2b (Tmc2b), varies depending on both hair c
Externí odkaz:
https://doaj.org/article/4c25673ba954489aaa52619208964ab3
Publikováno v:
Current Biology. 33:1295-1307.e3
ADAMTS1, MPDZ, MVD, and SEZ6:candidate genes for autosomal recessive nonsyndromic hearing impairment
Autor:
Saima Riazuddin, Sakina Rehman, Liz M Nouel-Saied, Muhammad Ansar, Anushree Acharya, Shaoyuan Zhu, Lana M. Pollock, Ghazanfar Ali, Regie Lyn P. Santos-Cortez, Wasim Ahmad, Thashi Bharadwaj, Jenna L. Everard, Asmat Ullah, Khurram Liaqat, Michael J. Bamshad, Suzanne M. Leal, Isabelle Schrauwen, Brian M. McDermott, Raja Hussain Ali, Abdul Nasir, Abdul Wali, Arnaud P. J. Giese, Deborah A. Nickerson, Zubair M. Ahmed
Publikováno v:
Bharadwaj, T, Schrauwen, I, Rehman, S, Liaqat, K, Acharya, A, Giese, A P J, Nouel-Saied, L M, Nasir, A, Everard, J L, Pollock, L M, Zhu, S, Bamshad, M J, Nickerson, D A, Ali, R H, Ullah, A, Wali, A, Ali, G, Santos-Cortez, R L P, Ahmed, Z M, McDermott, B M, Ansar, M, Riazuddin, S, Ahmad, W & Leal, S M 2022, ' ADAMTS1, MPDZ, MVD, and SEZ6 : candidate genes for autosomal recessive nonsyndromic hearing impairment ', European Journal of Human Genetics, vol. 30, pp. 22-33 . https://doi.org/10.1038/s41431-021-00913-x
Hearing impairment (HI) is a common disorder of sensorineural function with a highly heterogeneous genetic background. Although substantial progress has been made in the understanding of the genetic etiology of hereditary HI, many genes implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b3797ece0eb90be2e775eda90491d2
https://curis.ku.dk/ws/files/289458884/s41431_021_00913_x.pdf
https://curis.ku.dk/ws/files/289458884/s41431_021_00913_x.pdf
Autor:
Brian M. McDermott
Publikováno v:
Curr Biol
Animals have a remarkable ability to use local cues to orient in space in the absence of a panoramic fixed reference frame. Here we use the mechanosensory lateral line in larval zebrafish to understand rheotaxis, an innate oriented swimming evoked by
Autor:
Federico Gulluni, Lorenzo Prever, Huayi Li, Petra Krafcikova, Ilaria Corrado, Wen-Ting Lo, Jean Piero Margaria, Anlu Chen, Maria Chiara De Santis, Sophie J. Cnudde, Joseph Fogerty, Alex Yuan, Alberto Massarotti, Nasrin Torabi Sarijalo, Oscar Vadas, Roger L. Williams, Marcus Thelen, David R. Powell, Markus Schueler, Michael S. Wiesener, Tamas Balla, Hagit N. Baris, Dov Tiosano, Brian M. McDermott, Brian D. Perkins, Alessandra Ghigo, Miriam Martini, Volker Haucke, Evzen Boura, Giorgio Roberto Merlo, David A. Buchner, Emilio Hirsch
Publikováno v:
Science
Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting complexes required for transport)-–dependent control of membrane remodeling at the midbody, a subcellular organelle that defines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b7b8e4bf586cb0f98e5fc0fb47473f
http://hdl.handle.net/2318/1831621
http://hdl.handle.net/2318/1831621
Autor:
Shih Wei Chou, Hannah Weaver, Ruben Stepanyan, Zongwei Chen, Brian M. McDermott, Robin Woods Davis, Shengxuan Wang, Kayla Kindig, Shaoyuan Zhu, Michael R Dercoli
Publikováno v:
Hum Mol Genet
Perception of sound is initiated by mechanically gated ion channels at the tips of stereocilia. Mature mammalian auditory hair cells require transmembrane channel-like 1 (TMC1) for mechanotransduction, and mutations of the cognate genetic sequences r