Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Brian M Hagen"'
Autor:
Yongwang Zhong, Jiou Wang, Mark J Henderson, Peixin Yang, Brian M Hagen, Teepu Siddique, Bruce E Vogel, Han-Xiang Deng, Shengyun Fang
Publikováno v:
eLife, Vol 6 (2017)
Over 170 different mutations in the gene encoding SOD1 all cause amyotrophic lateral sclerosis (ALS). Available studies have been primarily focused on the mechanisms underlying mutant SOD1 cytotoxicity. How cells defend against the cytotoxicity remai
Externí odkaz:
https://doaj.org/article/7385a4b9f6ca41dc809a49f0ef1d3d6e
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133518 (2015)
To avoid spectral interference with common fluorophores in multicolor fluorescence microscopy, a fluid-phase tracer with excitation and emission in the violet end of the visible spectrum is desirable. CM-pyranine is easily synthesized and purified. I
Externí odkaz:
https://doaj.org/article/464b8e273d6b47ec8a94e6ce7d01e8da
Autor:
Peixin Yang, Teepu Siddique, Jiou Wang, Han Xiang Deng, Yongwang Zhong, Brian M. Hagen, Shengyun Fang, Bruce E. Vogel, Mark J. Henderson
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Over 170 different mutations in the gene encoding SOD1 all cause amyotrophic lateral sclerosis (ALS). Available studies have been primarily focused on the mechanisms underlying mutant SOD1 cytotoxicity. How cells defend against the cytotoxicity remai
Autor:
Mark J. Henderson, Jiou Wang, Peixin Yang, Teepu Siddique, Yongwang Zhong, Han Xiang Deng, Brian M. Hagen, Shengyun Fang, Bruce E. Vogel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d974e3cb4e18e0e686dc9fd99d6aca9e
https://doi.org/10.7554/elife.23759.021
https://doi.org/10.7554/elife.23759.021
Autor:
Stefan Luther, Volker Westphal, M. Saleet Jafri, Tobias Kohl, Stefan W. Hell, Ulrich Parlitz, Stephan E. Lehnart, Eva Wagner, Jan Hendrik Streich, Brigitte Korff, Julia H. Steinbrecher, Hoang Trong M. Tuan, George S.B. Williams, Marcel A. Lauterbach, Gerd Hasenfuss, W. Jonathan Lederer, Brian M. Hagen
Publikováno v:
Circulation Research
Circulation Research; Vol 111
Circulation Research; Vol 111
Rationale: Transverse tubules (TTs) couple electric surface signals to remote intracellular Ca 2+ release units (CRUs). Diffraction-limited imaging studies have proposed loss of TT components as disease mechanism in heart failure (HF). Objectives: Ob
Publikováno v:
Cell Calcium; Vol 52
The fluo family of indicators is frequently used in studying Ca(2+) physiology; however, choosing which fluo indicator to use is not obvious. Indicator properties are typically determined in well-defined aqueous solutions. Inside cells, however, the
Autor:
Moshe Giladi, Liron Boyman, Reuben Hiller, Brian M. Hagen, W. Jonathan Lederer, Daniel Khananshvili
Publikováno v:
Journal of Biological Chemistry. 286:28811-28820
The cardiac Na(+)/Ca(2+) exchanger (NCX) regulates cellular [Ca(2+)](i) and plays a central role in health and disease, but its molecular regulation is poorly understood. Here we report on how protons affect this electrogenic transporter by modulatin
Publikováno v:
Journal of Molecular and Cellular Cardiology. 45:28-31
Publikováno v:
Journal of Clinical Investigation. 117:1758-1762
Catecholamine-induced polymorphic ventricular tachycardia (CPVT) is a familial disorder caused by cardiac ryanodine receptor type 2 (RyR2) or calsequestrin 2 (CASQ2) gene mutations. To define how CASQ2 mutations cause CPVT, we produced and studied mi
Publikováno v:
Biophysical Journal. 108(2)
The role of calcium ion (Ca2+) in diverse cellular signaling pathways has been identified and investigated principally by using fluorescent chelators as indicators. Using the biophysical characteristics of a fluorescent Ca2+ indicator allows investig