Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Brian Mølgaard"'
Autor:
Frederic Jabs, Melanie Plum, Nick S. Laursen, Rasmus K. Jensen, Brian Mølgaard, Michaela Miehe, Marco Mandolesi, Michèle M. Rauber, Wolfgang Pfützner, Thilo Jakob, Christian Möbs, Gregers R. Andersen, Edzard Spillner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
IgE is linked to allergic diseases and there is a great interest in developing anti-IgE therapeutics. Here the authors characterize the binding of human IgE Fc to a single domain antibody (sdab) and show that the sdab induces a closed conformation, w
Externí odkaz:
https://doaj.org/article/100e1c2461b14a39be4cdf8caf230db8
Autor:
Michaela Miehe, Christian Möbs, Wolfgang Pfützner, Gregers R. Andersen, Edzard Spillner, Brian Mølgaard, Frederic Jabs, Rasmus K. Jensen
Publikováno v:
Jensen, R K, Jabs, F, Miehe, M, Mølgaard, B, Pfützner, W, Möbs, C, Spillner, E & Andersen, G R 2020, ' Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy ', Allergy: European Journal of Allergy and Clinical Immunology, vol. 75, no. 8 . https://doi.org/10.1111/all.14222
Background: IgE is the central antibody isotype in TH2-biased immunity and allergic diseases. The structure of intact IgE and the impact of IgE-targeting molecules on IgE however remain elusive. In order to obtain insights into IgE biology and the cl
Autor:
Brian Mølgaard, Lotte Bonde Bertelsen, Bjarne Kuno Møller, Màiri E. Smith, Peter Kristensen, Anja Bille Bohn, Hans Stødkilde-Jørgensen
Publikováno v:
Bertelsen, L B, Bohn, A B, Smith, M, Mølgaard, B, Møller, B, Stødkilde-Jørgensen, H & Kristensen, P 2014, ' Are endothelial outgrowth cells a potential source for future re-vascularization therapy? ', Experimental Gerontology, vol. 58, pp. 132-138 . https://doi.org/10.1016/j.exger.2014.07.021
PURPOSE: Endothelial progenitor cells (EPCs) represent a heterogeneous cell population that is believed to be involved in vasculogenesis after ischemic diseases. EPCs could have a potential for future therapies with the purpose of enhancing endotheli
Autor:
Melanie Plum, Rasmus K. Jensen, Michèle Myriam Rauber, Edzard Spillner, Brian Mølgaard, Michaela Miehe, Christian Möbs, Thilo Jakob, Gregers R. Andersen, Nick S. Laursen, Frederic Jabs, Marco Mandolesi, Wolfgang Pfützner
Publikováno v:
Aarhus University
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Jabs, F, Plum, M, Laursen, N S, Jensen, R K, Mølgaard, B, Miehe, M, Mandolesi, M, Rauber, M M, Pfützner, W, Jakob, T, Möbs, C, Andersen, G R & Spillner, E 2018, ' Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction ', Nature Communications, vol. 9, no. 1, 7 . https://doi.org/10.1038/s41467-017-02312-7
Nature Communications
'Nature Communications ', vol: 9, pages: 7-1-7-11 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Jabs, F, Plum, M, Laursen, N S, Jensen, R K, Mølgaard, B, Miehe, M, Mandolesi, M, Rauber, M M, Pfützner, W, Jakob, T, Möbs, C, Andersen, G R & Spillner, E 2018, ' Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction ', Nature Communications, vol. 9, no. 1, 7 . https://doi.org/10.1038/s41467-017-02312-7
Nature Communications
'Nature Communications ', vol: 9, pages: 7-1-7-11 (2018)
Anti-IgE therapeutics interfere with the ability of IgE to bind to its receptors on effector cells. Here we report the crystal structure of an anti-IgE single-domain antibody in complex with an IgE Fc fragment, revealing how the antibody inhibits int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f593722f83cefcebb3afcf5f3c22e56a
http://pure.au.dk/portal/en/publications/trapping-ige-in-a-closed-conformation-by-mimicking-cd23-binding-prevents-and-disrupts-fcri-interaction(5f8ae318-0d1b-49b9-8b3e-5e3a38651be6).html
http://pure.au.dk/portal/en/publications/trapping-ige-in-a-closed-conformation-by-mimicking-cd23-binding-prevents-and-disrupts-fcri-interaction(5f8ae318-0d1b-49b9-8b3e-5e3a38651be6).html