Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Brian M, Varisco"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Progressive emphysema often leads to end-stage lung disease. Most mouse models of emphysema are typically modest (i.e. cigarette smoke exposure), and changes over time are difficult to quantify. The tracheal porcine pancreatic elastase model
Externí odkaz:
https://doaj.org/article/1bb9a3d519304601b7f682915fe8b383
Autor:
Mihir R. Atreya, Shayantan Banerjee, Andrew J. Lautz, Matthew N. Alder, Brian M. Varisco, Hector R. Wong, Jennifer A. Muszynski, Mark W. Hall, L. Nelson Sanchez-Pinto, Rishikesan Kamaleswaran, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Chris J. Lindsell
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104938- (2024)
Summary: Background: Multiple organ dysfunction syndrome (MODS) disproportionately drives morbidity and mortality among critically ill patients. However, we lack a comprehensive understanding of its pathobiology. Identification of genes associated wi
Externí odkaz:
https://doaj.org/article/162e22e81e7c4a51b9298a80581e6c4c
Autor:
James G. Williams, Rashika Joshi, David Haslam, Nadir Yehya, Rhonda L. Jones, Aditi Paranjpe, Mario Pujato, Krishna M. Roskin, Patrick M. Lahni, Hector R. Wong, Brian M. Varisco
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Rationale While nasal brushing transcriptomics can identify disease subtypes in chronic pulmonary diseases, it is unknown whether this is true in pediatric acute respiratory distress syndrome (PARDS). Objectives Determine whether nasal trans
Externí odkaz:
https://doaj.org/article/c9cdb5a7dc7a4ea498a7431e044d6be5
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-10 (2020)
Abstract Background Acute respiratory distress syndrome (ARDS) is heterogeneous and may be amenable to sub-phenotyping to improve enrichment for trials. We aimed to identify subtypes of pediatric ARDS based on whole blood transcriptomics. Methods Thi
Externí odkaz:
https://doaj.org/article/fe7dba7581624893b93902fd6421f7cf
Autor:
Vincent Serapiglia, Chad A. Stephens, Rashika Joshi, Emrah Aydin, Marc Oria, Mario Marotta, Jose L. Peiro, Brian M. Varisco
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2022)
Fetal endoscopic tracheal occlusion (FETO) is an emerging surgical therapy for congenital diaphragmatic hernia (CDH). Ovine and rabbit data suggested altered lung epithelial cell populations after tracheal occlusion (TO) with transcriptomic signature
Externí odkaz:
https://doaj.org/article/5dcffa9b7bda428ab6ede9d9481e6a42
Autor:
Robert P Thomen, Jason C Woods, Peter F Sturm, Viral Jain, Laura L Walkup, Nara S Higano, James D Quirk, Brian M Varisco
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240265 (2020)
Adolescent idiopathic scoliosis (AIS) is associated with decreased respiratory quality of life and impaired diaphragm function. Recent hyperpolarized helium (HHe) MRI studies show alveolarization continues throughout adolescence, and mechanical force
Externí odkaz:
https://doaj.org/article/4f20546e98854845bb3a19fd388c2444
Autor:
Sarah J Atkinson, Brian M Varisco, Mary Sandquist, Meghan N Daly, Lindsey Klingbeil, Joshua W Kuethe, Emily F Midura, Kelli Harmon, Amy Opoka, Patrick Lahni, Giovanna Piraino, Paul Hake, Basilia Zingarelli, Joel E Mortensen, James L Wynn, Hector R Wong
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 455-463 (2016)
Abstract Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 (MMP8) improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothesized that developmental age
Externí odkaz:
https://doaj.org/article/bb6ee77a25884b63ba7c9179b3e415c4
Autor:
Brian M Varisco, Lourenco Sbragia, Jing Chen, Federico Scorletti, Rashika Joshi, Hector R Wong, Rebeca Lopes-Figueira, Marc Oria, Jose Peiro
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 398-411 (2016)
Abstract Congenital diaphragmatic hernia (CDH) causes severe pulmonary hypoplasia from herniation of abdominal contents into the thorax. Tracheal occlusion (TO) for human CDH improves survival, but morbidity and mortality remain high, and we do not f
Externí odkaz:
https://doaj.org/article/6cf54f687e81472490bb7b8cb7aff720
Autor:
Andrew J. Devine, Noah J. Smith, Rashika Joshi, Qiang Fan, Michael T. Borchers, Geremy C. Clair, Joshua N. Adkins, Brian M. Varisco
Chymotrypsin-like elastase 1 (CELA1) is a serine protease that is neutralized by α1-antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide model of AAT-deficient emphysema. Mice with genetic ablation of AAT do not have emphys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::090b972a36664a86938a32ed04ee9a9f
https://doi.org/10.21203/rs.3.rs-2617812/v1
https://doi.org/10.21203/rs.3.rs-2617812/v1
Publikováno v:
Pediatric research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::577eed2eb7946c43841eb1a2fd029edf
https://pubmed.ncbi.nlm.nih.gov/36481786
https://pubmed.ncbi.nlm.nih.gov/36481786