Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Brian M, Mathes"'
Autor:
Junliang Hao, James Beck, Xin Zhou, Gregory L. Lackner, Richard Johnston, Matt Reinhard, Paul Goldsmith, Sean Hollinshead, Veronique Dehlinger, Sandra A. Filla, Xu-shan Wang, Jeffery Richardson, Maria Posada, Mike Mohutsky, Doug Schober, Jason S. Katner, Qi Chen, Bingjie Hu, David M. Remick, David A. Coates, Brian M. Mathes, Mai K. Hawk, Kjell A. Svensson, Erik Hembre
Publikováno v:
Journal of Medicinal Chemistry. 65:3786-3797
Results from recently completed clinical studies suggest the dopamine D1 receptor positive allosteric modulator (PAM) mevidalen (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49a9e53e8ff14e333d25d7a619375ea
https://doi.org/10.1021/acs.jmedchem.1c01887
https://doi.org/10.1021/acs.jmedchem.1c01887
Autor:
Charles W, Lugar, Christian A, Clarke, Richard, Morphy, Helene, Rudyk, Selma, Sapmaz, Ryan E, Stites, Grant M, Vaught, Kelly, Furness, Howard B, Broughton, Greg L, Durst, David K, Clawson, Stephanie L, Stout, Sherry Y, Guo, Jim D, Durbin, Keith R, Stayrook, Denise D, Edmondson, Kristy, Kikly, Nicole E, New, Holly A, Bina, Mark G, Chambers, Pamela, Shetler, William Y, Chang, Veavi Ching-Yun, Chang, Rob, Barr, Wendy H, Gough, Jimmy P, Steele, Brian, Getman, Nita, Patel, Brian M, Mathes, Timothy I, Richardson
Publikováno v:
Journal of medicinal chemistry. 64(9)
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef03d39fb502b855beadc34c7a19e1e7
https://pubmed.ncbi.nlm.nih.gov/33852312
https://pubmed.ncbi.nlm.nih.gov/33852312
Autor:
Deyi, Zhang, Maria-Jesus, Blanco, Bai-Ping, Ying, Daniel, Kohlman, Sidney X, Liang, Frantz, Victor, Qi, Chen, Joseph, Krushinski, Sandra A, Filla, Kevin J, Hudziak, Brian M, Mathes, Michael P, Cohen, DeAnna, Zacherl, David L G, Nelson, David B, Wainscott, Suzanne E, Nutter, Wendy H, Gough, John M, Schaus, Yao-Chang, Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(19)
Preclinical experiments and clinical observations suggest the potential effectiveness of selective 5-HT1F receptor agonists in migraine. Identifying compounds with enhanced selectivity is crucial to assess its therapeutic value. Replacement of the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::143e37bcd53bad4bd106dfa8f1aa2e9b
https://pubmed.ncbi.nlm.nih.gov/26271587
https://pubmed.ncbi.nlm.nih.gov/26271587
Autor:
Brian M. Mathes, et al. et al.
Publikováno v:
ChemInform. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c9f0239131cfb5034ae78433b5f5e94
https://doi.org/10.1002/chin.200417145
https://doi.org/10.1002/chin.200417145