Výsledky vyhledávání - "Brian M, Eklov"

Practical Synthesis of 3-Oxa-6-azabicyclo[3.1.1]heptane Hydrotosylate; A Novel Morpholine-Based Building Block

Autor: Brian M. Eklov, Daniel P. Walker, Matthew W. Bedore

Publikováno v: Synthesis. 44:2859-2862

Bridged bicyclic morpholines are important building blocks in medicinal chemistry research. The bicyclic morpholine 3-oxa-6-azabicylo[3.1.1]heptane (3a) is of particular interest as a morpholine isostere because it is achiral and shows similar lipoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83f6188fbddeb367e209eec08b53217b
https://doi.org/10.1055/s-0032-1316748

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Neutral and Cationic Phosphoramide Adducts of Silicon Tetrachloride: Synthesis and Characterization of Their Solution and Solid-State Structures

Autor: Scott E. Denmark, Brian M. Eklov

Publikováno v: Chemistry - A European Journal. 14:234-239

The solution and solid-state structures of hexamethylphosphoramide (HMPA) adducts of tetrachlorosilane (SiCl 4 ) are discussed. In solution, the meridional and facial isomers of the hexa-coordinate cationic complex 3HMPA·SiCl 3 + Cl - (2) predominat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e09fd06583047f023ef48bfa47e176c
https://doi.org/10.1002/chem.200701466

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Reaction Titration: A Convenient Method for Titering Reactive Hydride Agents (Red-Al, LiAlH4, DIBALH, L-Selectride, NaH, and KH) by No-D NMR Spectroscopy

Autor: Brian M. Eklov, Andrew W. Aspaas, Thomas R. Hoye, Troy D. Ryba

Publikováno v: Organic Letters. 7:2205-2208

The concentration of reactive metal hydride (Met-H) reducing agents can be determined (inor = 20 min) using No-D NMR spectroscopy. The method involves (i) reacting Met-H with an excess of p-methoxybenzaldehyde, (ii) quenching with excess acetic acid,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01ce488e6f64ec8e07b66613e29cb52
https://doi.org/10.1021/ol0506011

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No-D NMR (No-Deuterium Proton NMR) Spectroscopy: A Simple Yet Powerful Method for Analyzing Reaction and Reagent Solutions

Autor: Troy D. Ryba, Thomas R. Hoye, Brian M. Eklov, Letitia J. Yao, Mikhail B Voloshin

Publikováno v: Organic Letters. 6:953-956

[reaction: see text] The title technique is a convenient and powerful method for directly monitoring or assaying any reaction mixture or reagent solution. Examples of some common processes (Fischer esterification, lithiation, butyllithium/THF compati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6fb9fd788f0f1826e166b259b9cde91
https://doi.org/10.1021/ol049979+

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Design, validation, and implementation of a rapid-injection NMR system

Autor: Scott E. Denmark, Bruce J. Williams, Son M. Pham, Gregory L. Beutner, Brian M. Eklov

Publikováno v: The Journal of organic chemistry. 75(16)

A Rapid Injection NMR (RINMR) apparatus has been designed and constructed to allow the observation of fast chemical reactions in real time by NMR spectroscopy. The instrument was designed to allow the rapid (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376939e97c0bfa5ad245a6d2d716b202
https://pubmed.ncbi.nlm.nih.gov/20672809

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On the mechanism of Lewis base catalyzed aldol addition reactions: kinetic and spectroscopic investigations using rapid-injection NMR

Autor: Peter J. Yao, Brian M. Eklov, Scott E. Denmark, Martin D. Eastgate

Publikováno v: Journal of the American Chemical Society. 131(33)

The mechanistic foundations of the Lewis base catalyzed aldol addition reactions have been investigated. From a combination of low-temperature spectroscopic studies ((29)Si and (31)P NMR) and kinetic analyses using a rapid-injection NMR apparatus (RI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f486f87e4bd856184648ac25d743312
https://pubmed.ncbi.nlm.nih.gov/19642696

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No-D NMR spectroscopy as a convenient method for titering organolithium (RLi), RMgX, and LDA solutions

Autor: Brian M. Eklov, Thomas R. Hoye, Mikhail B Voloshin

Publikováno v: Organic letters. 6(15)

[reaction: see text] The concentration of organolithium, organomagnesium halide, and lithium diisopropylamide solutions can be reliably determined using No-D NMR spectroscopy by integration against the added internal standard 1,5-cyclooctadiene (COD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ebe8550a6f2c2f48a55b28274e7be3
https://pubmed.ncbi.nlm.nih.gov/15255692

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No-D NMR (no-deuterium proton NMR) spectroscopy: a simple yet powerful method for analyzing reaction and reagent solutions

Autor: Thomas R, Hoye, Brian M, Eklov, Troy D, Ryba, Mikhail, Voloshin, Letitia J, Yao

Publikováno v: Organic letters. 6(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f84522030f355b3fc934d37e54a191e4
https://pubmed.ncbi.nlm.nih.gov/15012073

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Toward computing relative configurations: 16-epi-latrunculin B, a new stereoisomer of the actin polymerization inhibitor latrunculin B

Autor: Nadia E. Hashish, Brian M. Eklov, Seif-Eldin N. Ayyad, Mark T. Hamann, W. Thomas Shier, Khalid A. El Sayed, Thomas R. Hoye

Publikováno v: Journal of the American Chemical Society. 124(25)

The title compound, 16-epi-latrunculin B (3), has been isolated from the sponge Negombata magnifica collected from the Red Sea near Hurghada, Egypt. This new natural product was determined to be an epimer of latrunculin B (1), which was found in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f1af7708086c31bbad933df5cf6acb
https://pubmed.ncbi.nlm.nih.gov/12071749

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