Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Brian Luna"'
Autor:
Peggy Lu, Francesco Alletto, Bosul Lee, Elizabeth Burk, Jasmine Martinez, Fabio Prati, Emilia Caselli, Brad Spellberg, Brian Luna
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0287102 (2023)
Recently, we reported rifabutin hyper-activity against Acinetobacter baumannii. We sought to characterize if any additional rifamycins (n = 22) would also display hyper-activity when tested in iron-limited media against A. baumannii, K. pneumoniae, a
Externí odkaz:
https://doaj.org/article/ad60d1ef5d15411eb99a26636e488cc0
Autor:
Marlène Maeusli, Nicholas Skandalis, Bosul Lee, Peggy Lu, Sarah Miller, Jun Yan, Yuli Talyansky, Rachel Li, Zeferino Reyna, Noel Guerrero, Amber Ulhaq, Matthew Slarve, Ioannis Theologidis, Brad Spellberg, Brian Luna
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT Novel approaches to combating antibiotic resistance are needed given the ever-continuing rise of antibiotic resistance and the scarce discovery of new antibiotics. Little is known about the colonization dynamics and the role of intrinsic pla
Externí odkaz:
https://doaj.org/article/0295be0ddbe94d329abb045df3f02088
Autor:
Bosul Lee, Jun Yan, Amber Ulhaq, Sarah Miller, Wonjae Seo, Peggy Lu, Rosemary She, Brad Spellberg, Brian Luna
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT We recently reported that the antimicrobial activity of rifabutin against Acinetobacter baumannii is best modeled by the use of RPMI for in vitro susceptibility testing. Here, we define the effects of medium on the susceptibility and frequen
Externí odkaz:
https://doaj.org/article/d93849aae744420f96a3fc927649b5f7
Autor:
Yuli Talyansky, Travis B Nielsen, Jun Yan, Ulrike Carlino-Macdonald, Gisela Di Venanzio, Somnath Chakravorty, Amber Ulhaq, Mario F Feldman, Thomas A Russo, Evgeny Vinogradov, Brian Luna, Meredith S Wright, Mark D Adams, Brad Spellberg
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009291 (2021)
Acinetobacter baumannii is a highly antibiotic-resistant bacterial pathogen for which novel therapeutic approaches are needed. Unfortunately, the drivers of virulence in A. baumannii remain uncertain. By comparing genomes among a panel of A. baumanni
Externí odkaz:
https://doaj.org/article/2e15c8218812402f94d6020b9c41afb5
Autor:
Marlène Maeusli, Bosul Lee, Sarah Miller, Zeferino Reyna, Peggy Lu, Jun Yan, Amber Ulhaq, Nicholas Skandalis, Brad Spellberg, Brian Luna
Publikováno v:
mSphere, Vol 5, Iss 3 (2020)
ABSTRACT Agricultural use of antibiotics is recognized by the U.S. Centers for Disease Control and Prevention as a major contributor to antibiotic-resistant infections. While most One Health attention has been on the potential for antibiotic resistan
Externí odkaz:
https://doaj.org/article/cba93b122e474db59beeb97cbbc37e6f
Autor:
Brian L. Cheng, Travis B. Nielsen, Paul Pantapalangkoor, Fan Zhao, Jean C. Lee, Christopher P. Montgomery, Brian Luna, Brad Spellberg, Robert S. Daum
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 7, Pp 1609-1614 (2017)
Staphylococcus aureus is the leading cause of nosocomial and community-acquired infections, including soft tissue and skin infections and bacteremia. However, efforts to develop an effective vaccine against S. aureus infections have not been successf
Externí odkaz:
https://doaj.org/article/70b51f87362d4d5a95e92f9c94a2575f
Autor:
Nicholas Skandalis, Marlène Maeusli, Dimitris Papafotis, Sarah Miller, Bosul Lee, Ioannis Theologidis, Brian Luna
Publikováno v:
Antibiotics, Vol 10, Iss 6, p 640 (2021)
Antibiotic resistance represents a global health concern. Soil, water, livestock and plant foods are directly or indirectly exposed to antibiotics due to their agricultural use or contamination. This selective pressure has acted synergistically to ba
Externí odkaz:
https://doaj.org/article/9095164cc18545f19ad3f1bb7728ea60
Publikováno v:
Antibiotics, Vol 9, Iss 10, p 684 (2020)
Clostridioides difficile colitis overgrowth occurs when the normal gut microbiome becomes disrupted, often due to antibiotics. Effective treatment remains elusive, due partly to the persistence of its spores in the gut. Natural substances like manuka
Externí odkaz:
https://doaj.org/article/cc61a944f4784a5a80702f4cacb8dee4
Autor:
Christer Larsson, Brian Luna, Nicole C Ammerman, Mamoudou Maiga, Nisheeth Agarwal, William R Bishai
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e37516 (2012)
The seven WhiB proteins of Mycobacterium tuberculosis (M.tb) are widely believed to be redox-sensing transcription factors due to their binding of iron-sulfur clusters and similarities to DNA binding proteins. Here, we explored the nature of this hyp
Externí odkaz:
https://doaj.org/article/f813292fbaea4f15b10ff3970fa6056d
Autor:
Matthew Slarve, Zeferino Reyna, Elizabeth Burk, Juan Ruiz-Delgado, Rachel Li, Jun Yan, Brian Luna, Brad Spellberg
Publikováno v:
Antimicrobial Agents and Chemotherapy.
Acinetobacter baumannii is an extremely drug-resistant pathogen necessitating the development of new therapies. We seek to generate a cocktail of monoclonal antibodies (MAbs) that can target the full diversity of A. baumannii isolates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c9a177a41f2a22a8dced20f8a164a3c
https://doi.org/10.1128/aac.00086-23
https://doi.org/10.1128/aac.00086-23