Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Brian Linehan"'
Autor:
Ryan M Fryer, Mita Patel, Xiaomei Zhang, Katja S Baum-Kroker, Akalushi Muthukumarana, Brian Linehan, Yin-Chao Tseng
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Establishing a wide therapeutic index (TI) for pre-clinical safety is important during lead optimization (LO) in research, prior to clinical development, although is often limited by a molecules physiochemical characteristics. Recent advances in the
Externí odkaz:
https://doaj.org/article/f23ed065d90641de85aa0a48e9ca1c0d
Publikováno v:
Physical Chemistry Chemical Physics. 24:26485-26498
The phase boundaries and thermodynamic properties of crystal phases in the salicylic acid (SA) - anthranilic acid (AA) system have been determined experimentally. The complete binary T-X diagram reveals a total of four crystalline phases, including a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65907d971d10b8d10a36b53123ae46e
https://doi.org/10.1039/d2cp04200b
https://doi.org/10.1039/d2cp04200b
Autor:
Michelle Raikes, John A. Robson, Brian Linehan, Fredrik L. Nordström, Yongjian Wang, Huayu Li
Publikováno v:
Crystal Growth & Design. 21:4100-4110
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62654bba93817b799ecd802e8db94dee
https://doi.org/10.1021/acs.cgd.1c00399
https://doi.org/10.1021/acs.cgd.1c00399
Publikováno v:
Crystal Growth & Design. 20:1716-1728
The mechanisms of purging structurally similar impurities in solution crystallization have been evaluated using the model compound salicylic acid. Of the 11 added impurities, 3 showed appreciable e...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df5b0114f4951db3d12f2d6d43e83872
https://doi.org/10.1021/acs.cgd.9b01460
https://doi.org/10.1021/acs.cgd.9b01460
Publikováno v:
Crystal Growth & Design. 19:1336-1346
Crystallization from solution is a key unit operation utilized across the synthetic scheme to remove impurities. However, little is still known of the underlying impurity purge mechanisms that are ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b782cde94b9521e5b3ab91bbf8ad42f
https://doi.org/10.1021/acs.cgd.8b01734
https://doi.org/10.1021/acs.cgd.8b01734
Autor:
Christian Harcken, Morrison B. Mac, Melissa Hill-Drzewi, Debbie Studwell, Diva Sze-Ming Chan, Donna Terenzzio, Heather Xia, Mita Patel, Yu Hui, Brian Linehan, Pingrong Liu, Lynne Canne Bannen, Raymond A. Kemper, Louise K. Modis, Dustin Smith, Lemieux Rene M, Miller Craig Andrew, Darren Disalvo, Raj Betageri, Jeremy I. Levin, Kimberly Fletcher, Daniel Kuzmich, Lori Patenaude, Stephanie M. Ng, Yong Wang, Eugene R. Hickey, Wei Xu, John Lord, Monica Patel, Can Mao, Horan Joshua Courtney, Tamara Denise Hopkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:466-471
Poor solubility and cationic amphiphilic drug-likeness were liabilities identified for a lead series of S1P3-sparing, S1P1 agonists originally developed from a high-throughput screening campaign. This work describes the subsequent optimization of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f90de1a26b0429af17155e30674f6f
https://doi.org/10.1016/j.bmcl.2015.11.090
https://doi.org/10.1016/j.bmcl.2015.11.090
Publikováno v:
International Journal of Pharmaceutics. 491:208-217
A central composite design approach was applied to study the effect of polymer concentration, inlet temperature and air flow rate on the spray drying process of the Büchi B-90 nano spray dryer (B-90). Hypromellose acetate succinate-LF was used for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d85536e9c53da98849a66b38aecfa5
https://doi.org/10.1016/j.ijpharm.2015.06.006
https://doi.org/10.1016/j.ijpharm.2015.06.006
Publikováno v:
International Journal of Pharmaceutics. 466:368-374
A new combination approach of quasi-emulsion solvent diffusion (QESD) and confined impinging jet (CIJ) technologies was utilized to formulate pH-susceptible amorphous solid dispersions (ASDs) of a poorly soluble investigational compound (BI906) of Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd5ba5b94749bf30424e88aab7fde14
https://doi.org/10.1016/j.ijpharm.2014.03.042
https://doi.org/10.1016/j.ijpharm.2014.03.042
Autor:
Katja S. Baum-Kroker, Ryan M. Fryer, Mita Patel, Yin-Chao Tseng, Brian Linehan, Xiaomei Zhang, Akalushi Muthukumarana
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Frontiers in Pharmacology
Frontiers in Pharmacology
Establishing a wide therapeutic index (TI) for pre-clinical safety is important during lead optimization (LO) in research, prior to clinical development, although is often limited by a molecules physiochemical characteristics. Recent advances in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12e1ab8105b14dcc31b7ff753a128e7
Autor:
Dustin Smith, Ryan M. Fryer, Michael Markert, Brian Linehan, Brian Guth, Mita Patel, Yin-Chao Tseng, Khing Jow Ng
The aim of this study was to identify an adequate formulation for a poorly soluble lead molecule (BI-A) that would achieve sufficiently high plasma concentrations after oral administration in dogs to enable a robust cardiovascular safety pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847faf929b39f9fd0e193435e308fa7c
https://www.sciencedirect.com/science/article/pii/S0378517316307694
https://www.sciencedirect.com/science/article/pii/S0378517316307694
