Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Brian Lian"'
A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia
Autor:
Jin Zhou, Brian Lian, Hiroko Masamune, Paul M. Yen, Lauren R Waskowicz, Xiao Hui Liao, Samuel Refetoff, Andrea Lim, Brian Tran, Dwight D. Koeberl
Publikováno v:
Thyroid
Background: Glycogen storage disease type Ia (GSD Ia), also known as von Gierke disease, is the most common glycogen storage disorder. It is caused by the deficiency of glucose-6-phosphatase, the enzyme that catalyzes the final step of gluconeogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c1c0dd529474fbd7b60a56247af2db
https://europepmc.org/articles/PMC6707038/
https://europepmc.org/articles/PMC6707038/
Autor:
Brian Lian, Rohit Loomba, Joel Neutel, Carmen Margaritescu, Ken Homer, Amy Luk, Marianne Mancini, Summer Ji, Geoff Barker, Randall Severance, Rizwana Mohseni, David Bernard, Michael Dao
Publikováno v:
Journal of Hepatology. 73:S53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5030203c4c601bc42d232f3442f73fb5
https://doi.org/10.1016/s0168-8278(20)30652-8
https://doi.org/10.1016/s0168-8278(20)30652-8
Autor:
Joel Neutel, Hiroko Masamune, Marianne Mancini, Rizwana Mohseni, Brian Lian, Michael Dao, Rohit Loomba, Randall Severance, Carmen Margaritescu, Satinder Saini, David Bernard, Ken Homer, Brian Tran
Publikováno v:
Journal of Hepatology. 70:e150-e151
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4d67b187f91d516908a87d2260ba5a4
https://doi.org/10.1016/s0618-8278(19)30266-x
https://doi.org/10.1016/s0618-8278(19)30266-x
Autor:
Christopher M. Tegley, Chi-Hwei Lin, Xianghong Wang, Tae-Seong Kim, Tony I. Lee, Jennifer Dao, Christopher Mohr, Sandra Ross, Andrew Hague, Andrew Tasker, Steven R. Jordan, Philip Tagari, Brian Lian, Carol Mayeda, Teresa L. Burgess, Vellarkad N. Viswanadhan, Janet Cheetham, Yi-xin Qian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:87-90
A series of (4-piperidinylphenyl)aminoethyl amides based on dipeptide anilines were synthesized and tested against cathepsin K, cathepsin L and cathepsin B. These new non-covalent inhibitors exhibited single-digit nM inhibition of the cysteine protea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e401f40a1eba54fb7a9e3ebaa0e0694
https://doi.org/10.1016/j.bmcl.2003.10.009
https://doi.org/10.1016/j.bmcl.2003.10.009
Autor:
Jon Lorenz, Brian Lian, Kristi Contreras, Song Chung, James Russo, Wendy Trousdell, David Stevens
Publikováno v:
Biochemical Pharmacology. 50:399-406
As the physiologic roles for the different classes of aldehyde dehydrogenase (ALDH) enzymes are elucidated, the identification of specific, reversible inhibitors becomes of great pharmacologic interest. Previous structure-function studies identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d704a653b394916671bc2bb5cd80f7eb
https://doi.org/10.1016/0006-2952(95)00138-p
https://doi.org/10.1016/0006-2952(95)00138-p
Publikováno v:
Journal of the American College of Cardiology. 67:1932
Thyroid hormone is a key regulator of lipoprotein metabolism, particularly acting via the beta isoform of nuclear T3 receptor in liver. VK2809 is a small molecule prodrug of a potent thyroid beta agonist. VK2809 is selectively cleaved in hepatic tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::613a6095bddb482042b447477666eb22
https://doi.org/10.1016/s0735-1097(16)31933-7
https://doi.org/10.1016/s0735-1097(16)31933-7