Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Brian LeCuyer"'
Autor:
Xiaoying Liu, Mahmoud Khalafalla, Chuhan Chung, Yevgeniy Gindin, Susan Hubchak, Brian LeCuyer, Alyssa Kriegermeier, Danny Zhang, Wei Qiu, Xianzhong Ding, Deyu Fang, Richard Green
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 11, Pp 100289- (2022)
FXR regulates bile acid metabolism, and FXR null (Fxr−/−) mice have elevated bile acid levels and progressive liver injury. The inositol-requiring enzyme 1α/X-box binding protein 1 (XBP1) pathway is a protective unfolded protein response pathway
Externí odkaz:
https://doaj.org/article/bd9506ef4911427bb5ab74084c3f7683
Autor:
Alyssa Kriegermeier, Angela Hyon, Brian LeCuyer, Susan Hubchak, Xiaoying Liu, Richard M. Green
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Background Increased intrahepatic bile acids cause endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) is activated to maintain homeostasis. UPR dysregulation, including the inositol-requiring enzyme 1α/X-box protein 1 (IRE1α/
Externí odkaz:
https://doaj.org/article/c129784c84404872a68c52f784f96300
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 261-271 (2017)
Background & Aims: Cholestasis promotes endoplasmic reticulum (ER) stress in the liver, however, the effect of ER stress on hepatic bile acid metabolism is unknown. We aim to determine the effect of ER stress on hepatic bile acid synthesis and transp
Externí odkaz:
https://doaj.org/article/ab34f528b6d54a10a75f6cc8ce1bd357
Autor:
Alyssa Kriegermeier, Angela Hyon, Brian LeCuyer, Susan Hubchak, Xiaoying Liu, Richard M. Green
Background/AimsCholestatic liver diseases (CLD) are the leading indication for pediatric liver transplantation. Increased intrahepatic bile acid concentrations cause endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) is activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0096d2d5e348a90405bec4f7778ab49
https://doi.org/10.1101/2022.03.11.484034
https://doi.org/10.1101/2022.03.11.484034
Autor:
Xiaoying Liu, Mahmoud Khalafalla, Chuhan Chung, Yevgeniy Gindin, Susan Hubchak, Brian LeCuyer, Alyssa Kriegermeier, Danny Zhang, Wei Qiu, Xianzhong Ding, Deyu Fang, Richard Green
Background & AimsFarnesoid X receptor (FXR) regulates bile acid metabolism and FXR null (Fxr-/-) mice have elevated bile acid levels and progressive liver injury. The inositol-requiring enzyme 1α (IRE1α)/X-box binding protein 1 (XBP1) pathway is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d9d7a596a296811d41f2192d9b4e2dc
https://doi.org/10.1101/2022.03.04.482879
https://doi.org/10.1101/2022.03.04.482879
Autor:
Susan C. Hubchak, Angela Hyon, Richard M. Green, Alyssa Kriegermeier, Xiaoying Liu, Meredith A. Sommars, Brian LeCuyer, Grant D. Barish
Publikováno v:
Hepatology
BACKGROUND AND AIMS The unfolded protein response (UPR) is a coordinated cellular response to endoplasmic reticulum (ER) stress that functions to maintain cellular homeostasis. When ER stress is unresolved, the UPR can trigger apoptosis. Pathways wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c564d40f983ac8e5e91ce5cc51fa98
https://europepmc.org/articles/PMC8886505/
https://europepmc.org/articles/PMC8886505/
Autor:
Richard M. Green, Brian LeCuyer, Anne S. Henkel, Xiaoying Liu, Matthew J. Schipma, Kristy A. Anderson
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 309:G965-G974
Fatty liver is associated with endoplasmic reticulum stress and activation of the hepatic unfolded protein response (UPR). Reduced hepatic expression of the UPR regulator X-box binding protein 1 spliced (XBP1s) is associated with human nonalcoholic s
Autor:
Susan C. Hubchak, David B. Hilburn, Richard M. Green, Grace L. Guo, Xiaoying Liu, Li Wang, Deyu Fang, Antony Hsieh, Brian LeCuyer, Bo Kong, Seong Park
Bile acids are endogenous ligands of the nuclear receptor, farnesoid X receptor (FXR), and pharmacological FXR modulators are under development for the treatment of several liver disorders. The inositol-requiring enzyme 1α/X-box binding protein 1 (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea2c71381a8433a2176e3a5860188b6
https://europepmc.org/articles/PMC6033648/
https://europepmc.org/articles/PMC6033648/
Autor:
Susan C. Hubchak, Anne S. Henkel, Eric Zhang, Matthew J. Schipma, Xiaoying Liu, Brian LeCuyer, Richard M. Green
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 3, Pp 504-511 (2017)
The unfolded protein response (UPR) is an adaptive response to endoplasmic reticulum stress and the inositol-requiring enzyme 1α/X-box binding protein 1 (IRE1α/XBP1) pathway of the UPR is important in lipid metabolism. However, its role in bile aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468084af33d958057bd213c1354d93bd
https://europepmc.org/articles/PMC5335580/
https://europepmc.org/articles/PMC5335580/
Publikováno v:
Gastroenterology. 156:S-1191