Výsledky vyhledávání - "Brian Lawhorn"

Abstract 4964: SW-682: A novel TEAD inhibitor for the treatment of cancers bearing mutations in the Hippo signaling pathway

Autor: Lei Chen, Paula Milani de Marval, Kendall Powell, Mark Johnson, Greg Falls, Brian Lawhorn, Aurélie Candi, Amuri Kilonda, Bart Vanderhoydonck, Arnaud Marchand, Matthias Versele, Georg Halder, Stephen L. Gwaltney, Adeela Kamal

Publikováno v: Cancer Research. 83:4964-4964

Many cancers harbor mutations in the Hippo pathway that lead to constitutive activation of the transcriptional co-activators YAP/TAZ that then bind the transcription factor TEAD and drive aberrant transcription of target genes involved in cell prolif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff72fff7f3b3f1feb5934f47b68973aa
https://doi.org/10.1158/1538-7445.am2023-4964

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Sulfonamides in the design of pharmacological tools and drug candidates

Autor: Brian Lawhorn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8ed14402473993ebcb53e63f6cc2910
https://doi.org/10.1021/scimeetings.0c00461

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Highly soluble TRPV4 antagonists for oral and IV delivery

Autor: Brian Lawhorn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2583cf5029114325bdb3ea8a71916c72
https://doi.org/10.1021/scimeetings.0c00290

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