Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Brian Laing"'
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2020 (2020)
BioMed Research International, Vol 2020 (2020)
Background. The skull encompasses and houses one of the most important organs in the body—the brain—and like all tissues in the body, it is comprised of living cells that are constantly remodeling as this maintains the strength and homeostasis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45d23b9487eb3af01990694160d8c5b
https://pubmed.ncbi.nlm.nih.gov/32149137
https://pubmed.ncbi.nlm.nih.gov/32149137
Autor:
Brian Laing
Publikováno v:
Network Security. 2017:11-13
There are many inconvenient truths regarding cybercrime. Every second in 2016, someone became a victim of cybercrime, meaning around a million people were affected – whether it was by data breaches, fraud or malware – every single day. Cybercrime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84a626b462a621ea0ec28b15c3f4ce2a
https://doi.org/10.1016/s1353-4858(17)30103-4
https://doi.org/10.1016/s1353-4858(17)30103-4
Autor:
Xin Ming, Brian Laing
Publikováno v:
Advanced Drug Delivery Reviews. 87:81-89
Bioconjugates have been used to deliver therapeutic oligonucleotides to their pharmacological targets in diseased cells. Molecular-scale conjugates can be prepared by directly linking targeting ligands with oligonucleotides and the resultant conjugat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e1024585b29999be2a3b49710bf80e
https://doi.org/10.1016/j.addr.2015.02.002
https://doi.org/10.1016/j.addr.2015.02.002
Publikováno v:
Chemical Communications. 51:6678-6680
Activation of photosensitizers in endosomes enables release of therapeutic macromolecules into the cytosol of the target cells for pharmacological actions. In this study, we demonstrate that direct conjugation of photosensitizers to oligonucleotides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac4a183888bfe138366590471e116ab
https://doi.org/10.1039/c5cc00573f
https://doi.org/10.1039/c5cc00573f
Publikováno v:
Telemedicine and e-Health. 17:19-24
Telemedicine options for symptom assessment include both telephonic means (call centers) and Internet sites. Although symptom assessment call centers have been available for decades, symptom assessment over the Internet is relatively new. It is not w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9ca343faf88bca0be392924c8e5a59
https://doi.org/10.1089/tmj.2010.0120
https://doi.org/10.1089/tmj.2010.0120
Autor:
Rudolph L. Juliano, Brian Laing
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(9)
The construction of nanomaterials from oligonucleotides by modular assembly invariably requires the use of branched nucleic acid architectures such as three- and four-way junctions (3WJ and 4WJ). We describe the stabilization of DNA 3WJ by using non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b608d9366d87a75117e397b8af4bdd
https://pubmed.ncbi.nlm.nih.gov/25953428
https://pubmed.ncbi.nlm.nih.gov/25953428
Autor:
Mark J. Suto, Emily A. Hull-Ryde, William P. Janzen, Ahu Yuan, Xin Ming, Bing Yang, Joseph A. Maddry, Melissa A. Porter, Rudy L. Juliano, Brian Laing, Canhong Cao
Publikováno v:
Nucleic Acids Research
The therapeutic use of antisense and siRNA oligonucleotides has been constrained by the limited ability of these membrane-impermeable molecules to reach their intracellular sites of action. We sought to address this problem using small organic molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f17005862106744a4d09d9cfb3957e
Autor:
Leonard William, Mirlinda Biba, Derek W. Henderson, Christopher J. Welch, Tiebang Wang, Jennifer Albaneze-Walker, Sandra Spencer, Brian Laing, and Xiaodong Bu, David J. Mathre, Jimmy O. DaSilva
Publikováno v:
Organic Process Research & Development. 9:198-205
A microtube screening approach affords simple and convenient assessment of the selective adsorption of metal impurities by a variety of different process adsorbents. This approach is helpful in identifying rapid solutions to metal impurity problems i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e3a53570d7785d4ee296bec72917b5
https://doi.org/10.1021/op049764f
https://doi.org/10.1021/op049764f
One of the major constraints on the therapeutic use of oligonucleotides is inefficient delivery to their sites of action in the cytosol or nucleus. Recently it has become evident that the pathways of cellular uptake and intracellular trafficking of o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340651755f391a8d297bcf9801613f43
Autor:
Janet Raines, James D. Neaton, Brian Laing, Marcella Link, Ken Svendsen, Patricia J. Elmer, Jeremiah Stamler, Nancy Van Heel, Greg Grandits, Eleanor Betz, Richard H. Grimm
Publikováno v:
Preventive Medicine. 24:378-388
Background. Questions regarding the efficacy of nonpharmacologic approaches for the treatment of stage 1 hypertension were addressed as part of the Treatment of Mild Hypertension Study (TOMHS), a 4-year, randomized clinical trial (N = 902). This repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22017e641fe614ae37050b58c381742b
https://doi.org/10.1006/pmed.1995.1062
https://doi.org/10.1006/pmed.1995.1062